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Biofilms in chronic rhinosinusitis

Current Opinion in Otolaryngology & Head & Neck Surgery, 2010
Rhinosinusitis is one of the most common medical complaints in the United States, affecting up to 16% of the population. It is associated with over 13 million physician visits per year and an estimated aggregated cost of over $6 billion annually. Patients with chronic rhinosinusitis (CRS) demonstrate worse quality-of-life scores than those suffering ...
Noam A. Cohen   +2 more
openaire   +3 more sources

Chronic Rhinosinusitis in Children

Pediatric Clinics of North America, 2013
Chronic rhinosinusitis (CRS) affects nearly 37 million people in the United States each year and accounts for approximately $6 billion in direct and indirect health care costs. Despite its prevalence and significant impact, little is known about its exact cause and pathophysiology, and significant controversy remains regarding appropriate treatment ...
Austin S. Rose   +3 more
openaire   +3 more sources

Osteitis in Chronic Rhinosinusitis

Current Allergy and Asthma Reports, 2019
Osteitis is recognized as a common factor in recalcitrant chronic rhinosinusitis (CRS). There is evidence for the association of osteitis with revision surgeries and CRS severity, in terms of higher Lund-Mackay scores. This is a narrative review on the osteitis in CRS patients.Evidence to date is inconclusive with regard to the etiology and ...
Kornkiat Snidvongs   +3 more
openaire   +3 more sources

Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial.

The Lancet Respiratory Medicine, 2021
Joseph K. Han   +12 more
semanticscholar   +1 more source

Microbiology of chronic rhinosinusitis

European Journal of Clinical Microbiology & Infectious Diseases, 2016
Most sinus infections are viral and only a small percentage develop bacterial infection. Rhino-, influenza, and para-influenza viruses are the most frequent viral causes of sinusitis. The most common bacterial isolates from children and adult patients with community-acquired acute bacterial sinusitis are Streptococcus pneumoniae, Haemophilus influenzae,
openaire   +3 more sources

Phenotypes in Chronic Rhinosinusitis

Current Allergy and Asthma Reports, 2020
Chronic rhinosinusitis (CRS) is a heterogenous disease process affecting a significant proportion of the population and impacting quality of life and productivity. Historically, CRS has been classified broadly into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Increased understanding regarding unique presentations of CRS subsets
Jessica W. Grayson   +4 more
openaire   +2 more sources

Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis

Nature Immunology, 2022
Weiqing Wang   +19 more
semanticscholar   +1 more source

Diagnosis of Chronic Rhinosinusitis

Annals of Otology, Rhinology & Laryngology, 2004
Chronic rhinosinusitis is a multifactorial disease defined as inflammation of the nasal cavity and paranasal sinuses with a history of at least 12 weeks in duration. The major symptoms include facial pressure or pain, nasal obstruction, discharge or purulence, and hyposmia or anosmia.
openaire   +3 more sources

Revision surgery rates in chronic rhinosinusitis with nasal polyps: meta‐analysis of risk factors

International Forum of Allergy and Rhinology, 2019
Wide variations in revision endoscopic sinus surgery (ESS) rates for chronic rhinosinusitis with nasal polyposis (CRSwNP) have been reported. It is important to understand expected revision rates and factors that impact the need for revision.
Catherine A Loftus   +6 more
semanticscholar   +1 more source

Endotypes of chronic rhinosinusitis

Current Opinion in Otolaryngology & Head & Neck Surgery, 2019
Purpose of review In contrast to the phenotypic classification of chronic rhinosinusitis (CRS), endotyping categorizes disease variants based on their underlying pathophysiologic mechanisms. Defining CRS endotypes may provide information on the risk for disease progression, recurrence and comorbid conditions, as well as ...
Eric Monteiro, Yvonne Chan, Jonathan Yip
openaire   +2 more sources

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