Results 81 to 90 of about 5,345,179 (257)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Psychological Hardiness and Burnout in the Context of Post-Traumatic Stress Disorder Among South African First Responders

Chronic Stress
Background Exposure to traumatic events is an inherent aspect of first responder work, placing individuals at heightened risk for post-traumatic stress disorder (PTSD) and burnout.
Anita Padmanabhanunni, Tyrone B Pretorius   +1 more
doaj   +1 more source

Frontal Lobe Circuitry in Posttraumatic Stress Disorder

Chronic Stress, 2019
Symptoms of posttraumatic stress disorder include hyperarousal, avoidance of trauma-related stimuli, re-experiencing of trauma, and mood changes.
Lynn D. Selemon, Keith A. Young, Dianne A. Cruz, Douglas E. Williamson   +3 more
doaj   +1 more source

The endurance athletes heart: acute stress and chronic adaptation

, 2012
The impact of endurance exercise training on the heart has received significant research and clinical attention for well over a century. Despite this, many issues remain controversial and clinical interpretation can be complex of biomarkers of ...
Gaze, D.C., Green, D.J., Somauroo, J., George, K., Whyte, G.P., Shave, R.E., Oxborough, D.   +6 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Combat Exposure Severity Is Associated With Reduced Cortical Thickness in Combat Veterans: A Preliminary Report

Chronic Stress, 2017
Background Chronic stress and related physiological responses are known to have deleterious effects on neural integrity. Combat exposure is a notoriously pathogenic stressor, and with over 2 million U.S. troops deployed to active combat zones since 2001,
Lynnette A. Averill, Chadi G. Abdallah, Robert H. Pietrzak, Christopher L. Averill, Steven M. Southwick, John H. Krystal, Ilan Harpaz-Rotem   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Back to the Basics: Resting State Functional Connectivity of the Reticular Activation System in PTSD and its Dissociative Subtype

Chronic Stress, 2019
Background Brainstem and midbrain neuronal circuits that control innate, reflexive responses and arousal are increasingly recognized as central to the neurobiological framework of post-traumatic stress disorder (PTSD).
Janine Thome, Maria Densmore, Georgia Koppe, Braeden Terpou, Jean Théberge, Margaret C. McKinnon, Ruth A. Lanius   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Pretreatment Brain Connectome Fingerprint Predicts Treatment Response in Major Depressive Disorder

Chronic Stress, 2020
Background Major depressive disorder (MDD) treatment is characterized by low remission rate and often involves weeks to months of treatment. Identification of pretreatment biomarkers of response may play a critical role in novel drug development, in ...
Siyan Fan, Samaneh Nemati, Teddy J. Akiki, Jeremy Roscoe, Christopher L. Averill, Samar Fouda, Lynnette A. Averill, Chadi G. Abdallah   +7 more
doaj   +1 more source