Results 31 to 40 of about 10,452 (187)

De Novo 2.2 Mb 19q13.42–q13.43 Microdeletion Encompassing U2AF2: Support for a Haploinsufficiency Model

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT U2 small nuclear RNA auxiliary factor 2 (U2AF2) is an essential pre‐mRNA splicing factor involved in the early stages of pre‐mRNA splicing. To date, multiple individuals have been reported with predominantly heterozygous missense variants presenting intellectual disability, speech and motor delays, seizures, hypotonia, and thin or hypoplastic ...
Amanda Toledo, Sarah Araji, Weimin Bi, Seema R. Lalani   +3 more
wiley   +1 more source

Single versus double drainage in chronic subdural hematomas treated with burr-holes

Revista Cubana de Medicina Militar, 2023
Introduction: Chronic subdural hematoma is a frequent type of intracranial hemorrhage. Treatment for symptomatic cases is generally surgical. Burr-hole completion is the method of choice.
Ernesto Enrique Horta-Tamayo, Luis Cesar Acosta-Gonzalez, Diana Rosa Ortega-Raez, Lazaro Noel Parra-Vidal, Martha Suarez-Cruz   +4 more
doaj  

Acute on chronic bilateral subdural hematoma presenting with acute complete flaccid paraplegia and urinary retention mimicking an acute spinal cord injury: a case report

BMC Research Notes, 2017
Background A subdural hematoma refers to a collection of blood between the dura and the arachnoid membranes and is classified into acute, sub acute and chronic.
H. M. M. T. B. Herath, Anne Thushara Matthias, Aruna Kulatunga   +2 more
doaj   +1 more source

A guide to neuromodulation in drug‐resistant epilepsy

Epileptic Disorders, EarlyView.
Abstract Neuromodulation is approved for the treatment of drug‐resistant epilepsy. It has been increasingly utilized over the past two decades with the approval of deep brain stimulation (DBS) and responsive neurostimulation (RNS) in addition to vagus nerve stimulation (VNS)—particularly in patients who are not deemed to be good resective surgical ...
Prachi Parikh, Irena Dolezawa, Manu Hegde, Lukas Imbach, Brian N. Lundstrom, Francesca Pizzo, Vikram R. Rao, Jaysingh Singh, Derek Southwell, Satsuke Watanabe, Birgit Frauscher   +10 more
wiley   +1 more source

Exploring the efficacy and safety of perampanel in epilepsia partialis continua: A case series

Epileptic Disorders, EarlyView.
Abstract Background Epilepsia partialis continua (EPC) is a form of focal motor status epilepticus (SE), which is commonly drug‐resistant requiring treatment with multiple antiseizure medications (ASM). There are no established guidelines for pharmacological management.
Setareh Lahsaee, Kristin M. Ikeda, Stephanie Woodroffe, Benjamin P. Whatley   +3 more
wiley   +1 more source

Seizure relapse in new onset epilepsy: It is not always drug resistance

Epilepsia, EarlyView.
Abstract Objective Seizure recurrence in new onset epilepsy (NOE) can result from various factors. Although drug ineffectiveness is frequently investigated, other causes—such as nonadherence, inadequate treatment, nonepileptic events (e.g., functional/dissociative), or acute symptomatic seizures—also impact patient outcomes.
Cecilia Catania, Eric Menetre, Aikaterini Fitsiori, Felix Tobias Kurz, Gabriela Moreno Legast, Serge Vulliemoz, Mathieu Genoud, Pierre Mégevand, Roland Wiest, Fabienne Picard, Sandor Beniczky, Margitta Seeck   +11 more
wiley   +1 more source

Trial of Dexamethasone for Chronic Subdural Hematoma [PDF]

New England Journal of Medicine, 2020
Chronic subdural hematoma is a common neurological disorder mainly affecting older people.1 It consists of a collection of blood and blood breakdown products in the intracranial subdural space that liquefies over time; the inciting event often is minor head trauma; subsequent inflammation may play a role in the pathogenesis.2 The time of onset of ...
Hutchinson, Peter J., Edlmann, Ellie, Bulters, Diederik, Zolnourian, Ardalan, Holton, Patrick, Suttner, Nigel, Agyemang, Kevin, Thomson, Simon, Anderson, Ian A., Al-Tamimi, Yahia, Henderson, Duncan, Whitfield, Peter, Gherle, Monica, Brennan, Paul M., Allison, Annabel, Thelin, Eric P., Tarantino, Silvia, Pantaleo, Beatrice, Caldwell, Karen, Davis-Wilkie, Carol, Mee, Harry, Warburton, Elizabeth A., Barton, Garry, Chari, Aswin, Marcus, Hani J., King, Andrew T., Belli, Antonio, Myint, Phyo K., Wilkinson, Ian, Santarius, Thomas, Turner, Carole, Bond, Simon, Kolias, Angelos G., British Neurosurgical Trainee Research Collaborative and Dex-CSDH Trial Collaborators   +33 more
openaire   +5 more sources

Responsive stimulation of the thalamus for idiopathic generalized epilepsy: Results of the randomized controlled NAUTILUS trial through 18 months

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate the safety and effectiveness of responsive thalamic stimulation as adjunctive therapy for drug‐resistant idiopathic generalized epilepsy (IGE) with generalized tonic–clonic seizures (GTCSs). Methods NAUTILUS is a prospective, multicenter, single‐blind, randomized sham‐controlled pivotal trial ...
Utku Uysal, Patrick Landazuri, David E. Burdette, Sanjay Patra, Angela N. Crudele, Dario J Englot, Jay R. Gavvala, Sandipan Pati, Lesley C. Kaye, Steven Ojemann, Daniel Barnett, Joseph Neimat, Adriana E. Palade, Shervin Rahimpour, Amir A. Arain, Robert Mark Richardson, Sydney S. Cash, Vicenta Salanova, Alexandra Urban, William P. Welch, Jamie Joseph Van Gompel, Keith Starnes, David Spencer, Lia D. Ernst, Ushtar Amin, Angelica Rivera‐Cruz, Patricia Dugan, Marytery Fajardo, Matt Lallas, Barbara C. Jobst, Nicole Odom, Jarod L. Roland, Jon T. Willie, Sameer A. Sheth, Alica M. Goldman, Christopher T. Skidmore, Chengyuan Wu, Cornelia Drees, Jonathon Parker, Taneeta Mindy Ganguly, Jerzy Szaflarski, Saadi Ghatan, Lise Johnson, Jacob Norman, Brett Wingeier, Cairn G. Seale, Martha J. Morrell, Nautilus Study Group   +47 more
wiley   +1 more source

History of Chronic Subdural Hematoma [PDF]

Korean Journal of Neurotrauma, 2015
Trephination or trepanation is an intentional surgical procedure performed from the Stone Age. It looks like escaping a black evil from the head. This technique is still used for treatment of chronic subdural hematoma (SDH). Now, we know the origin, pathogenesis and natural history of this lesion.
openaire   +2 more sources

Rapid Spontaneous Resolution of Contralateral Acute Subdural Hemorrhage Caused by Overdrainage of Chronic Subdural Hemorrhage [PDF]

Journal of Neurocritical Care, 2018
Background Since the first report of a rapidly resolved subdural hemorrhage (SDH) in 1986, few additional case reports have been presented in the literature. Case Report An 82-year-old female patient presented with a SDH over the left convexity.
Minwook Yoo, Jung-Soo Kim
doaj   +1 more source