Results 51 to 60 of about 20,146 (201)

Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis

British Journal of Clinical Pharmacology, EarlyView.
Intravenous tobramycin is a first‐line treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF). Tobramycin exhibits concentration‐dependent activity; however, excess drug exposure can lead to nephrotoxicity and ototoxicity. While dosing typically targets serum peak (Cmax) and trough (Cmin) concentrations, the area under the ...
Kiera H. Harwood, Sarah Bannister, Stephen Duffull, April Martinez, Sarath Ranganathan, Shivanthan Shanthikumar, Amanda Gwee   +6 more
wiley   +1 more source

Aberrant spontaneous brain activity in chronic tinnitus patients revealed by resting-state functional MRI

NeuroImage: Clinical, 2014
Objective: The neural mechanisms that give rise to the phantom sound of tinnitus are poorly understood. This study aims to investigate whether aberrant spontaneous brain activity exists in chronic tinnitus patients using resting-state functional magnetic
Yu-Chen Chen, Jian Zhang, Xiao-Wei Li, Wenqing Xia, Xu Feng, Bo Gao, Sheng-Hong Ju, Jian Wang, Richard Salvi, Gao-Jun Teng   +9 more
doaj   +1 more source

Revisiting Baclofen for the Treatment of Severe Chronic Tinnitus [PDF]

Frontiers in Neurology, 2012
Subjective tinnitus is a phantom sensation of sound, which has been estimated to occur in 25.3% of people in the USA, with 7.9% experiencing it frequently (Shargorodsky et al., 2010). Drugs are one of a number of potential treatment avenues for severe chronic tinnitus.
Smith, Paul F., Zheng, Yiwen, Darlington, Cynthia L.   +2 more
openaire   +3 more sources

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

The burden of the postictal state in epilepsy: A prospective, single‐center observational cohort study

Epileptic Disorders, EarlyView.
Abstract Objective The postictal state is a major yet underrecognized component of the epilepsy burden. We aimed to develop a structured patient‐reported instrument to quantify postictal recovery, characterize its multidimensional burden, and identify demographic, clinical, psychiatric, and treatment‐related factors associated with postictal severity ...
Ionuț‐Flavius Bratu, Agnès Trébuchon, Fabrice Bartolomei   +2 more
wiley   +1 more source

Chronic Tinnitus is Associated with Aging but not Dementia

Hearing Research
Abstract Background Aging is related to deterioration of bodily and neural functions, leading to various disorders and symptoms, including the development of dementia, hearing loss, or tinnitus. Understanding how these phenomena are intertwined and how aging affects those is crucial for prevention ...
Lisa Reisinger, Nathan Weisz
openaire   +2 more sources

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

Epilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen, Vivian W. Y. Liao, Tomasz S. Mieszczanek, Anne V. Jakobsen, Elena Gardella, Kern Olofsson, Marina Nikanorova, Allan Bayat, Sebastian Ortiz, Sarah Weckhuysen, Cecilie Johannessen Landmark, Orrin Devinsky, Mary Chebib, Philip K. Ahring, Guido Rubboli, Rikke S. Møller   +15 more
wiley   +1 more source

Korean survey data reveals an association of chronic laryngitis with tinnitus in men.

PLoS ONE, 2018
The association between chronic laryngitis and tinnitus is not a well-studied topic, unlike the association of these two conditions with many other disorders.
Myung Jin Ban, Won Shik Kim, Ki Nam Park, Jae Wook Kim, Seung Won Lee, Kyungdo Han, Jae Won Chang, Hyung Kwon Byeon, Yoon Woo Koh, Jae Hong Park   +9 more
doaj   +1 more source

Cognitive mechanisms in chronic tinnitus: Psychological markers of a failure to switch attention

Frontiers in Psychology, 2016
The cognitive mechanisms underpinning chronic tinnitus (phantom auditory perceptions) are underexplored but may reflect a failure to switch attention away from a tinnitus sound.
Krysta Jannaya Trevis, Neil M McLachlan, Sarah J Wilson   +2 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source