Results 91 to 100 of about 76,687 (267)

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

Annals of Neurology, EarlyView.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante, Francesca Pischiutta, Elena Restelli, Federico Moro, Maria Antonietta Chiaravalloti, Ilaria Raimondi, Ilaria Bertani, Ilaria Lisi, Eliana Sammali, Rosaria Pascente, Serena Scozzari, Laura Pasetto, Carly Douglas, Marco Locatelli, Fabrizio Ortolano, Valentina Bonetto, David J. Loane, Nino Stocchetti, Roberto Chiesa, Elisa R. Zanier   +19 more
wiley   +1 more source

Variation in TMEM106B in chronic traumatic encephalopathy

Acta Neuropathologica Communications, 2018
The genetic basis of chronic traumatic encephalopathy (CTE) is poorly understood. Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodegenerative disease, and ...
Jonathan D. Cherry, Jesse Mez, John F. Crary, Yorghos Tripodis, Victor E. Alvarez, Ian Mahar, Bertrand R. Huber, Michael L. Alosco, Raymond Nicks, Bobak Abdolmohammadi, Patrick T. Kiernan, Laney Evers, Sarah Svirsky, Katharine Babcock, Hannah M. Gardner, Gaoyuan Meng, Christopher J. Nowinski, Brett M. Martin, Brigid Dwyer, Neil W. Kowall, Robert C. Cantu, Lee E. Goldstein, Douglas I. Katz, Robert A. Stern, Lindsay A. Farrer, Ann C. McKee, Thor D. Stein   +26 more
doaj   +1 more source

Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer. [PDF]

, 2014
We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls.
Hardy, J, Holton, JL, Houlden, H, Kara, E, Lees, AJ, Ling, H, Martino, D, Plant, GT, Revesz, T   +8 more
core   +2 more sources

Chronic Traumatic Encephalopathy in the Brains of Military Personnel.

New England Journal of Medicine, 2022
BACKGROUND Persistent neuropsychiatric sequelae may develop in military personnel who are exposed to combat; such sequelae have been attributed in some cases to chronic traumatic encephalopathy (CTE).
David S. Priemer, D. Iacono, C. Rhodes, C. Olsen, Daniel P. Perl   +4 more
semanticscholar   +1 more source

Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths

Annals of Neurology, EarlyView.
Objective Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether tau pathology in Alzheimer's disease (AD) preferentially affects sulci, and particularly sulcal depths.
Samira A. Maboudian, Corrina S. Fonseca, Adam C. Martersteck, Yishu Chao, Yuheng Chen, Daniela Ushizima, Duygu Tosun, Lea T. Grinberg, Kevin S. Weiner, William J. Jagust, for the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source

Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy

Molecular Neurodegeneration
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) accumulation. The clinical features associated with CTE pathology are unclear.
M. Alosco, Micaela White, Carter A. Bell, Farwa Faheem, Yorghos Tripodis, E. Yhang, Zachary H. Baucom, Brett Martin, J. Palmisano, K. Dams-O'Connor, J. Crary, Lee E. Goldstein, Douglas I Katz, Brigid Dwyer, Daniel H. Daneshvar, Christopher J. Nowinski, Robert C. Cantu, Neil W. Kowall, Robert A. Stern, Victor E. Alvarez, B. Huber, T. Stein, Ann C. McKee, Jesse B. Mez   +23 more
semanticscholar   +1 more source

Association of APOE Genotypes and Chronic Traumatic Encephalopathy

JAMA Neurology, 2022
This genetic association study tests the association between APOE genotype and chronic traumatic encephalopathy neuropathology and related endophenotypes.
Kathryn F Atherton, Xudong Han, Jaeyoon Chung, Jonathan D. Cherry, Zachary H. Baucom, Nicole Saltiel, Evan S Nair, Bobak Abdolmohammadi, Madeline Uretsky, Mohammed Muzamil Khan, Conor Shea, Shruti Durape, Brett M. Martin, J. Palmisano, K. Farrell, Christopher J. Nowinski, Victor E. Alvarez, Brigid Dwyer, Daniel H. Daneshvar, D. Katz, L. Goldstein, R. Cantu, N. Kowall, M. Alosco, B. Huber, Yorghos Tripodis, J. Crary, L. Farrer, R. Stern, T. Stein, A. Mckee, Jesse B. Mez   +31 more
semanticscholar   +1 more source

Chronic traumatic encephalopathy and athletes [PDF]

Neurology, 2015
Recent case reports have described athletes previously exposed to repetitive head trauma while participating in contact sports who later in life developed mood disorders, headaches, cognitive difficulties, suicidal ideation, difficulties with speech, and aggressive behavior.
William, Meehan, Rebekah, Mannix, Ross, Zafonte, Alvaro, Pascual-Leone   +3 more
openaire   +2 more sources

Navigating the Complexities of Traumatic Encephalopathy Syndrome (TES): Current State and Future Challenges

Biomedicines, 2023
Chronic traumatic encephalopathy (CTE) is a unique neurodegenerative disease that is associated with repetitive head impacts (RHI) in both civilian and military settings.
Arman Fesharaki-Zadeh
doaj   +1 more source

Brain edema : a valid endpoint for measuring hepatic encephalopathy? [PDF]

, 2016
Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease.
Bémeur, Chantal, Cooper, Arthur J. L., Cudalbu, Cristina, Dam, Gitte, Rose, Christopher, Thrane, Alexander S.   +5 more
core   +1 more source