Results 171 to 180 of about 76,687 (267)

APOE4 and cognition in intracranial atherosclerosis: beyond Alzheimer's pathology

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The apolipoprotein E ε4 (APOE ε4) allele is a major genetic risk factor for Alzheimer's disease, but its relevance to cognition in intracranial atherosclerosis (ICAS) remains unclear. We investigated the association between APOE ε4 and cognition in ICAS. METHODS Baseline data from a multicenter cohort were analyzed.
Anqi Cheng, Yinxi Zou, Linwen Liu, Hebo Wang, Zhibing Ai, Shiwen Wu, Qianqian Si, Yiyang Liu, Huanyu Zhou, Haoyao Guo, Qiuyu Yu, Zijue Wang, Mingli Li, Caiyan Liu, Weihai Xu   +14 more
wiley   +1 more source

Classification of tauopathies from human brain homogenates through salt‐modulated tau amplification

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Tauopathies are a heterogeneous group of neurodegenerative disorders defined by abnormal aggregation of tau protein. Although cryogenic electron microscopy (cryo‐EM) has uncovered disease‐specific tau structures, translating these insights into diagnostic tools remains difficult. METHODS We developed a heparin‐free, salt‐modulated
Alessia Santambrogio, Michael A. Metrick II, Peifeng Xu, Nicholas C. T. Gallagher, Shunsuke Koga, Bernardino Ghetti, Dennis W. Dickson, Byron Caughey, Michele Vendruscolo   +8 more
wiley   +1 more source

Methylene Blue Reduced Brain Edema, Neuroinflammation, and Behavioral Deficits associated with a Moderate Traumatic Brain Injury [PDF]

, 2013
Neuroscience Signature Program Poster Day Professional Development Award, 2012NMS Undergraduate Research Forum Award, 2013Denman Undergraduate Research Forum Honorable Mention, 2013Treatment for traumatic brain injury (TBI) is aimed at mitigating the ...
Skendelas, John
core  

Areas of research priorities in epilepsy: A position paper of the European Reference Network for Rare and Complex Epilepsies, EpiCARE

Epilepsia Open, Volume 11, Issue 1, Page 291-321, February 2026.
Abstract Objective To define and articulate research priorities in epilepsy identified by the European Reference Network for Rare and Complex Epilepsies (ERN EpiCARE), addressing key unmet needs across the spectrum of rare and complex epilepsies. Methods This position paper was developed through a structured collaborative process involving patient ...
Sébile Tchaicha, Stéphane Auvin, Sándor Beniczky, Andreas Brunklaus, Lieven Lagae, Emilio Perucca, Rainer Surges, Sophie Adler, Christoph Helmstaedter, Floor Jansen, Guido Rubboli, Philippe Ryvlin, Nicola Specchio, Eugen Trinka, Ingmar Blümcke, Valentina de Giorgis, Katarzyna Kotulska, Gaetan Lesca, Masa Malenica, Amy McTague, Rima Nabbout, Rikke Steensbjerre Møller, Sandra Silva Arrieta, Isabella Brambilla, Małgorzata Kosla, Kees Braun, J. Helen Cross, Alexis Arzimanoglou   +27 more
wiley   +1 more source

The personal utility of genetic testing in children with epilepsy

Journal of Genetic Counseling, Volume 35, Issue 1, February 2026.
Abstract Genetic testing is increasingly utilized in the diagnosis and management of pediatric epilepsy, yet its personal impact on families remains underexplored. This study evaluated the personal utility of genetic testing based on caregiver‐reported experiences.
Sneha Gupta, Heather Leduc‐Pessah, Nick Barrowman, Anne Tsampalieros, Dennis Newhook, David Dyment, Daniela Pohl   +6 more
wiley   +1 more source

Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?

Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley   +1 more source

The Role of MRI in Debunking the Fallacy of “Mild” Traumatic Brain Injury

Journal of Magnetic Resonance Imaging, Volume 63, Issue 2, Page 297-309, February 2026.
ABSTRACT Mild traumatic brain injury (mTBI) is a prevalent yet often overlooked public health concern due to the absence of detectable abnormalities on CT or conventional MRI scans. Approximately 18.3%–31.3% of mTBI patients experience persistent symptoms 3–6 months post‐injury, despite normal imaging results, making diagnosis and treatment challenging.
Xingye Chen, David Wright, Sohae Chung, Yvonne Lui   +3 more
wiley   +1 more source

Value of Clinical Evidence and Health Economics and Outcomes Research (HEOR) Studies

Muscle &Nerve, Volume 73, Issue S1, Page S7-S12, February 2026.
ABSTRACT Randomized controlled trials (RCTs) remain the gold standard for establishing the efficacy and safety of new treatments. However, clinical evidence derived from the systematic analysis of real‐world data generated through routine clinical practice can complement RCT data by offering insights into treatment performance in broader, more ...
Agessandro Abrahao, Malgorzata Ciepielewska, Lorne Zinman   +2 more
wiley   +1 more source

Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models

VIEW, Volume 7, Issue 1, February 2026.
Imaging of amyloid‐beta plaque and tau accumulation in rodent and nonhuman primate model of Alzheimer's disease. Created in BioRender. Ni R. 2026. https://BioRender.com/a97h5ec Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates.
Ruiqing Ni, Axel Rominger
wiley   +1 more source

Dropped jaw as a feature of suspected nutritional encephalopathy in a cat

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 3‐year‐1‐month‐old female neutered domestic shorthair cat was presented for reluctance to jump over 3 months. Neurological and orthopaedic examinations, laboratory tests and cerebrospinal fluid analysis were unremarkable. Magnetic resonance imaging revealed mild bilateral symmetrical intra‐axial changes in the caudal brainstem.
Eleftheria Skovola, Oliver Williams, Serena Maini, Abbe Crawford   +3 more
wiley   +1 more source