Results 81 to 90 of about 3,068,792 (354)

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Transient improvement of urticaria induces poor adherence as assessed by Morisky Medication Adherence Scale-8. [PDF]

, 2015
Poor adherence to medication is a major public health challenge. Here, we aimed to determine the adherence to oral and topical medications and to analyze underlying associated factors using the translated Japanese version of Morisky Medication Adherence ...
Abe, Masatoshi, Abe, Shinya, Furue, Masutaka, Hagihara, Akihito, Hiragun, Takaaki, Imafuku, Shinichi, Inomata, Naoko, Kaneko, Sakae, Katoh, Norito, Kitami, Yuki, Kobayashi, Miwa, Masuda, Koji, Morisky, Donald E, Murota, Hiroyuki, Onozuka, Daisuke, Saeki, Hidehisa, Shintani, Yoichi, Sugaya, Makoto, Takeuchi, Satoshi, Tanioka, Miki, Tsunemi, Yuichiro   +20 more
core  

Management of chronic urticaria in children: a clinical guideline

Italian Journal of Pediatrics, 2019
The aim of this guidance is to provide recommendations to clinicians and other interested parties on chronic urticaria in children. The Italian Society for Pediatrics (SIP), the Italian Society for Allergy and Immunology (SIAIP), the Italian Society for ...
C. Caffarelli, F. Paravati, M. El Hachem, M. Duse, M. Bergamini, G. Simeone, M. Barbagallo, R. Bernardini, P. Bottau, Filomena Bugliaro, S. Caimmi, F. Chiera, G. Crisafulli, C. de Ranieri, D. Di Mauro, A. Diociaiuti, F. Franceschini, M. Gola, A. Licari, L. Liotti, C. Mastrorilli, D. Minasi, F. Mori, I. Neri, A. Pantaleo, F. Saretta, C. F. Tesi, G. Corsello, G. Marseglia, A. Villani, F. Cardinale   +30 more
semanticscholar   +1 more source

Total IgE as a Marker for Chronic Spontaneous Urticaria

Allergy Asthma and Immunology Research, 2021
Objective Immunoglobulin E (IgE) and its receptor, FcɛRI, importantly contribute to the pathophysiology of chronic spontaneous urticaria (CSU). Recent findings point to a possible role of total IgE as a marker of CSU disease activity, endotypes, and ...
S. Altrichter, J. Fok, Q. Jiao, P. Kolkhir, P. Pyatilova, S. Romero, J. Scheffel, F. Siebenhaar, Carolin Steinert, D. Terhorst‐Molawi, Y. Xiang, M. Church, M. Maurer   +12 more
semanticscholar   +1 more source

Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis With Polyangiitis: Findings From a Large European Cohort

Arthritis &Rheumatology, EarlyView.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a small vessel vasculitis characterized by eosinophilia, asthma, and ear, nose, and throat (ENT) involvement. Although glucocorticoids (GCs) are effective in controlling symptoms, relapses and GC dependence are common. The aim of this study was to develop predictive models for vasculitis
Matthias Papo, Pauline Martinot, Renato A. Sinico, Vítor Silvestre‐Teixeira, Nils Venhoff, Maria‐Letizia Urban, Michele Iudici, Juliane Mahrhold, Francesco Locatelli, Giulia Cassone, Franco Schiavon, Benjamin Seeliger, Thomas Neumann, Claudia Feder, Matthieu Groh, Chiara Marvisi, Maxime Samson, Thomas Barba, David Jayne, Arianna Troilo, Jens Thiel, Bernhard Hellmich, Sara Monti, Carlomaurizio Montecucco, Carlo Salvarani, Jean‐Emmanuel Kahn, Bernard Bonnotte, Cécile‐Audrey Durel, Xavier Puéchal, Luc Mouthon, Loïc Guillevin, Giacomo Emmi, Augusto Vaglio, Raphaël Porcher, Benjamin Terrier, on behalf of the French Vasculitis Study Group and the Eosinophilic Granulomatosis with Polyangiitis European Study Group   +35 more
wiley   +1 more source

Omalizumab rapidly improves angioedema‐related quality of life in adult patients with chronic spontaneous urticaria: X‐ACT study data [PDF]

, 2018
Background: The X‐ACT study aimed to examine the effect of omalizumab treatment on quality of life (QoL) in chronic spontaneous urticaria (CSU) patients with angioedema refractory to high doses of H1‐antihistamines. Methods: In X‐ACT, a phase III, double‐
Barbosa, Bernstein, Bork, Brooks, Choi, Finlay, Finlay, Grattan, Hallak, Herguner, James, Kaplan, Krieger, Maurer, Maurer, Maurer, McCormack, Metz, Metz, Saini, Saini, Shikiar, Staubach, Staubach, Weller, Weller, Weller, Zazzali, Zhao, Zuberbier   +29 more
core   +1 more source

Chronic Urticaria: An Overview of Treatment and Recent Patents

Recent Patents on Inflammation & Allergy Drug Discovery, 2019
Background: Up to 1% of the general population in the USA and Europe suffer from chronic urticaria (CU) at some point in their lifetime. CU has an adverse effect on the quality of life. Objective: This study aims to provide an update on the epidemiology,
K. Hon, A. Leung, W. Ng, S. Loo
semanticscholar   +1 more source

An Open-Label, Proof-of-Concept Study of Lirentelimab for Antihistamine-Resistant Chronic Spontaneous and Inducible Urticaria.

Journal of Allergy and Clinical Immunology, 2021
BACKGROUND Chronic urticaria (CU) is a debilitating mast cell-driven disease, often refractory to standard therapy (i.e., antihistamines). Lirentelimab, an anti-Siglec-8 monoclonal antibody, selectively inhibits mast cells and depletes eosinophils ...
S. Altrichter, P. Staubach, M. Pasha, Bhupinder B. Singh, A. Chang, J. Bernstein, H. Rasmussen, F. Siebenhaar, M. Maurer   +8 more
semanticscholar   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Evaluation of anxiety in children diagnosed with chronic urticaria

Medicine Science
This study aimed to evaluate anxiety levels in children diagnosed with chronic urticaria and to compare them with those in a healthy control group. Designed as a cross-sectional study, it included children aged 9–18 years diagnosed with chronic urticaria
Ugur Altas, Halil Alkaya, Seda Cevik, Mehmetcan Sezer, Firat Oz, Zeynep Meva Altas, Mehmet Yasar Ozkars   +6 more
doaj   +1 more source