Results 171 to 180 of about 6,255,411 (296)

The Four Domains of chronic disease prevention : working toward healthy people in healthy communities [PDF]

Modern efforts to prevent disease, help people lead healthier lives, and end health disparities must include a focus on chronic diseases.Chronic diseases\u2014heart disease and stroke, diabetes, cancer, chronic lung diseases, and others\u2014account for ...

core  

Comparison of venous morphology, chronic venous disease stage, and venous symptoms in high-impact activities versus low-impact activities. [PDF]

J Vasc Surg Venous Lymphat Disord
Béliard S, Mourot L, Thomas H, Tordi N, Ferreira D.   +4 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Genome-wide association studies in chronic venous disease: A systematic review. [PDF]

J Vasc Surg Venous Lymphat Disord
Soh CL, Tan M, Davies AH, Onida S.
europepmc   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Effectiveness of Micronized Purified Flavonoid Fraction on Quality of Life in Patients with Chronic Venous Disease: A Systematic Review and Meta-analysis. [PDF]

Clin Drug Investig
Santiago FR, Celovska D, Thomis S, Blanc-Guillemaud V, Onselaer MB, Serifou S, Yaltirik HP, Bokuchava M.   +7 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

A New Pearl in Chronic Venous Disease Pathophysiology-The Duplex Ultrasound and the Elastographic Features of Lymph Nodes Varicose Veins in the Groin. [PDF]

Diagnostics (Basel)
Dulgheriu IT, Solomon C, Timofte S, Ciurea AI, Dudea SM.   +4 more
europepmc   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

Effectiveness of micronized purified flavonoid fraction in early stage chronic venous disease-Clinical, Etiological, Anatomical, and Pathophysiological C0s-C1: A systematic review and meta-analysis. [PDF]

J Vasc Surg Venous Lymphat Disord
Eliete B, Igor Z, Miguel A, Augusto M, Vanessa BG, Marie-Blanche O, Soumeya S, Pelin YH, Mustafa S, Armando M.   +9 more
europepmc   +1 more source