Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source
The right heart perspective in chronic cardiorenal syndrome: the key role of right heart function and tricuspid regurgitation innovation. [PDF]
Yin X, Tang L, Liu J, Zhang Y.
europepmc +1 more source
Catheter removal and outcomes of multidrug-resistant central-line-associated bloodstream infection [PDF]
Burnham, Jason P. +2 more
core +1 more source
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang +16 more
wiley +1 more source
Association of Venous Thromboembolism Risk with Atopic Dermatitis and Janus Kinase Inhibitors Treatment: A Mendelian Randomization Study. [PDF]
Chen Z, Wang S, Wang Y.
europepmc +1 more source
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen +22 more
wiley +1 more source
A Rare but Severe Long-Term Complication of an Implantable Chamber. [PDF]
Grolleau R +5 more
europepmc +1 more source
Venous Blood Gas (VBG) Analysis Is as Safe and Equally Reliable as Arterial Blood Gas (ABG) Analysis in the Determination of Prognosis in Chronic Liver Disease Patients: A Study Conducted in a Tertiary Care Hospital in Uttar Pradesh, India [PDF]
Manish Bansal +5 more
openalex +1 more source

