Increased risk of deep vein thrombosis, pulmonary embolism, and all-cause mortality in chronic venous disorder: a large-scale retrospective cohort study. [PDF]
Moderegger EL +9 more
europepmc +1 more source
Cancer Immunotherapy via Disruption of Integrin αvβ3 and CD47 Costabilization on Cancer Cell Surface
This study identifies a cancer‐specific interaction between CD47 and integrin αvβ3 that facilitates immune evasion. A rationally designed peptide, PSFL‐NK13, disrupts this axis, enhancing macrophage‐mediated phagocytosis and suppressing tumor growth without inducing anemia.
Peng‐Cheng Yu +12 more
wiley +1 more source
The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases [PDF]
Abdala, Ana P +13 more
core +1 more source
Pathophysiology of Primary Budd-Chiari Syndrome: A Narrative Review. [PDF]
Montes López AK +3 more
europepmc +1 more source
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu +17 more
wiley +1 more source
Enteropathic arthritis is associated with an increased risk of major adverse cardiovascular events and venous thromboembolism. [PDF]
Williams JC +4 more
europepmc +1 more source
Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang +16 more
wiley +1 more source
Duplex Ultrasound Investigation of the Veins in Chronic Venous Disease of the Lower Limbs—UIP Consensus Document. Part II. Anatomy [PDF]
Attilio Cavezzi +7 more
openalex +1 more source

