Results 201 to 210 of about 215,504 (264)

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Platelet-Rich Plasma in a Refractory Venous Leg Ulcer Following Multiple Failed Skin Grafts. [PDF]

Int Wound J
Seretis K, Peponi D, Bounas N, Vergidou A, Christaki E.   +4 more
europepmc   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Chinese expert consensus on wound repair of venous leg ulcers (2025 edition). [PDF]

Mil Med Res
Zhang PH, Fu XB, Huang YS, Wound Repair Professional Committee of Chinese Medical Doctor Association.   +3 more
europepmc   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Effects of Endovenous Radiofrequency Ablation on Right Ventricular Functions and Pulmonary Hemodynamics in Superficial Venous Insufficiency. [PDF]

J Cardiovasc Dev Dis
Aslan M, Özgül M, Sanrı US, Karahan O.   +3 more
europepmc   +1 more source

Ninety-day venous thromboembolism incidence and associated risk factors after total and reverse shoulder arthroplasty: a national database analysis. [PDF]

J Shoulder Elb Arthroplast
Elias LH, Allen M, Adeleye O, Shah AA, Patel M, Lederman ES.   +5 more
europepmc   +1 more source

A Prospective Cohort Study of Hard-to-Heal Chronic Foot and Leg Wounds Followed for up to 20 Weeks After Initiation of ReGenerating Tissue Agents (RGTA) Technology as an Add-on to Optimal Local Care. [PDF]

Int Wound J
Ynesta S, Mourgues M, Geri C, Inizan M, Barritault D, Sedel F, Kerihuel JC, Téot L.   +7 more
europepmc   +1 more source

Cerebellar abscess complicating chronic suppurative otitis media: An unusual route of intracranial spread. [PDF]

Radiol Case Rep
Soldo L, Grgić S, Pehar I, Kokić M, Dervišević Bevanda S, Redžić L, Sarić Zolj B, Grubeša Raguž S, Dalmatin Dragišić M.   +8 more
europepmc   +1 more source

Genetic overlap between estimated glomerular filtration rate and cardiovascular disease identifies potential targets for cardiorenal syndrome. [PDF]

Ren Fail
Li W, Chen Y, Xiong W, Yuan S.
europepmc   +1 more source