Case Report: Micronized purified flavonoid fraction [Daflon]-induced bradycardia [PDF]
Frontiers in PharmacologyIntroductionFlavonoids are oral venoactive drugs frequently prescribed to relieve the symptoms of chronic venous disorders. Micronized purified flavonoid fraction (MPFF, commercial Daflon 1000 mg) is a preparation that contains mainly diosmin and a small
Jhennyfer Aline Lima Rodrigues +2 more
doaj +4 more sources
MUFFIN-PTS trial, Micronized Purified Flavonoid Fraction for the Treatment of Post-Thrombotic Syndrome: protocol of a randomised controlled trial [PDF]
BMJ Open, 2021 Introduction After deep vein thrombosis, up to 50% of patients develop post-thrombotic syndrome (PTS). PTS is a chronic condition that reduces quality of life (QOL).
Grégoire Le Gal +6 more
doaj +2 more sources
Is There a Difference in the Clinical Efficacy of Diosmin and Micronized Purified Flavonoid Fraction for the Treatment of Chronic Venous Disorders? Review of Available Evidence [PDF]
Vascular Health and Risk Management, 2021 Michèle Cazaubon,1 Jean-Patrick Benigni,2 Marcio Steinbruch,3 Violaine Jabbour,4 Christelle Gouhier-Kodas4 1Private Vascular Specialist, Paris, France; 2Pedagogical Support Office, Faculty of Medicine Pitié-Salpétrière, Sorbonne University, Paris, France;
Cazaubon M +4 more
doaj +2 more sources
Efficacy of escin combined with micronized purified flavonoid fraction in controlling bleeding and preventing recurrence of acute internal hemorrhoids: a randomized controlled trial [PDF]
Annals of ColoproctologyPurpose Recurrence after initial control of acute internal hemorrhoidal bleeding remains a common and clinically relevant challenge. Escin, a venotonic and anti-inflammatory compound, may augment the therapeutic effects of micronized purified flavonoid ...
Witcha Vipudhamorn +4 more
doaj +2 more sources
Micronized purified flavonoid fraction for the treatment of chronic venous insufficiency, with a focus on postthrombotic syndrome: A narrative review [PDF]
Research and Practice in Thrombosis and Haemostasis, 2021 Introduction Postthrombotic syndrome (PTS) is a form of secondary chronic venous insufficiency (CVI) that occurs after deep vein thrombosis (DVT). Effective treatments for PTS are lacking.
Ke Xuan Li +4 more
doaj +2 more sources
Micronized purified flavonoid fraction (daflon) improves sexual function by modulating NF-kB /NO/cGMP and steroidogenic signaling in cisplatin-treated male Wistar rats [PDF]
Biochemistry and Biophysics ReportsCisplatin is known to induce sexual dysfunction by suppressing testosterone levels. It also upregulates nuclear factor-kappa B (NF-kB), which mediates nitric oxide (NO)-dependent endothelial dysfunction.
Akhigbe RE, Akhigbe TM, Adegbola CA
doaj +2 more sources
Role of a Micronized Purified Flavonoid Fraction as an Adjuvant Treatment to Rubber Band Ligation for the Treatment of Patients With Hemorrhoidal Disease: A Longitudinal Cohort Study [PDF]
Annals of Coloproctology, 2019 Purpose Nonsurgical treatment of hemorrhoidal disease (HD) includes medical and instrumental techniques. We aimed to compare the efficacy of the most frequently used nonsurgical strategies, either alone or in combination, applied in an ambulatory setting.
Ana Célia Caetano +4 more
doaj +2 more sources
Effectiveness of Conservative Treatment on Chronic Venous Disease Symptoms and Quality of Life in Patients with Type 2 Diabetes: Results from a Subanalysis of the VEIN STEP Observational Study [PDF]
Vascular Health and Risk ManagementJorge Hernando Ulloa,1 Zoubida Tazi Mezalek,2 Alejandro José González Ochoa,3 Faezeh Hosseini Sadrabadi,4 Vanessa Blanc-Guillemaud,4 Jean-Christophe Philips,5 Toni Feodor6 1Department of Vascular Surgery, Santa Fe de Bogotá Foundation, University of the ...
Ulloa JH +6 more
doaj +2 more sources
The aCute HemORrhoidal disease evALuation International Study (CHORALIS): Subanalysis of the effectiveness of conservative treatment during the acute phase of hemorrhoidal disease in Vietnam [PDF]
Journal of International Medical ResearchBackground Although hemorrhoidal disease is common worldwide, real-world evidence on the effectiveness of conservative treatments during the acute phase remains limited.
Nguyen Trung Tin +6 more
doaj +2 more sources
An international observational study assessing conservative management in hemorrhoidal disease: results of CHORALIS (aCute HemORrhoidal disease evALuation International Study) [PDF]
Journal of Comparative Effectiveness ResearchAim: Real-world evidence on the management of hemorrhoidal disease (HD) is limited. This international study collected clinical practice data on the effectiveness of conservative treatments for acute HD on symptoms and quality of life (QoL), providing ...
Philippe Godeberge +11 more
doaj +2 more sources