Results 41 to 50 of about 412 (149)

RETRACTED: Pathogenetic substantiation of phlebotropic therapy for chronic venous diseases

Амбулаторная хирургия, 2019
RETRACTED ARTICLEChronic venous disease (CVD) is the most common vascular pathology that has a significant negative effect on physical and psychological health outcomes, and requires high level of public spending on healthcare. Number of CVD risk factors
V. Yu. Bogachev, A. Mansilla, B. V. Boldin, S. V. Rodionov, O. V. Dzhenina   +4 more
doaj   +1 more source

PHLEBOPROTECTORS BASED ON FLAVONOIDS: DOSAGE FORMS, BIOPHARMACEUTICAL CHARACTERISTICS, TECHNOLOGICAL FEATURES

Фармация и фармакология (Пятигорск), 2021
Micronized purified flavonoid fraction (MPFF) is the original phlebotropic drug. Its marketed form (Detralex®) consists of 90% diosmin and 10% of other flavonoids. Calculated as hesperidin, it is the most widely used drug today.
E. F. Stepanova, I. P. Remezova, A. M. Shevchenko, A. V. Morozov, V. K. Maltseva   +4 more
doaj   +1 more source

Pelvic venous disorders in women: Diagnosis and management for gynecologists

International Journal of Gynecology &Obstetrics, Volume 174, Issue 3, Page 1267-1276, September 2026.
Abstract Pelvic venous disorders (PeVD) are an underrecognized yet significant cause of chronic pelvic pain (CPP) in reproductive‐aged women, characterized by venous reflux, obstruction, or both. This clinical opinion provides a practical overview of PeVD for gynecologists, outlining its pathophysiology, common presentations, diagnostic approach, and ...
Tiffany Ni, Inbar Friedman, Jessica Smith, Brian Liu, Mary Melchior, Andrew D. Brown   +5 more
wiley   +1 more source

Natural Product‐Derived Vesicles in Nanotherapeutics

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley   +1 more source

A perioperative phlebotropic therapy compliance study in patients with varicose veins

Амбулаторная хирургия, 2020
Introduction: Lower extremity varicose vein disease is one of the common problems in vascular surgery. Clinically, this disease is accompanied by a wide range of complaints and external symptoms, which eventually lead to a worse patients’ quality of life.
S. N. Zhabin, A. A. Shitikov, A. V. Tsukanov, E. G. Obedkov, S. S. Dudchenko, V. A. Murenova, A. D. Khizhnyak, K. E. Belova   +7 more
doaj   +1 more source

SRM 1650b Administration to Isolated Rat Heart Aggravates Ischemia‐Reperfusion Injury via Mitochondrial Dysfunction and Downregulation of PI3K/Akt Signaling Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
SRM 1650b diesel particulate matter caused dose‐dependent cardiotoxicity in isolated male Wistar rat hearts, worsening hemodynamics and tissue injury after ischemia–reperfusion. It increased oxidative stress, impaired mitochondrial bioenergetics and respiration, downregulated mitochondrial quality‐control genes, reduced mtDNA copy number, and ...
Kirankumar Balu, Uvasshri Vijayakumar, Bhavana Sivakumar, Priyanka N. Prem, Gino A. Kurian   +4 more
wiley   +1 more source

A combination of bioflavonoid, oral thrombolytic and anticoagulant in the treatment of thrombophlebitis of varicose veins in outpatient surgical practice

Амбулаторная хирургия
Introduction. Comparability of the outcomes of treatment of patients with thrombophlebitis of varicose veins using surgical intervention and medical therapy, a wide range of drugs have become the basis for conducting this study.Aim.
E. P. Krivoshchekov, A. V. Poseryaev, M. Yu. Khoroshilov, V. E. Romanov, B. M. Rakhimov, A. V. Kazantsev, S. Zh. Kirgizbaev   +6 more
doaj   +1 more source

Phlebopathies: from pathogenesis to treatment

Амбулаторная хирургия, 2023
Introduction. The prevalence of phlebopathies varies from 15 to 31%. The QoL of patients with phlebopathies is impaired. Phlebotropic therapy is the main method for treating phlebopathies. Aim. Evaluation of the efficacy and safety of micronized purified
V. Yu. Bogachev, B. V. Boldin, P. Yu. Turkin, O. V. Dzhenina, O. A. Alukhanyan, N. V. Bogacheva   +5 more
doaj   +1 more source

Cocrystallization and Micronization as Strategies to Optimize the Bioavailability of Naringin and Naringenin Molecules: A Comprehensive Review of In Vivo and In Vitro Pharmaceutical Applications

Crystal Research and Technology, Volume 61, Issue 7, July 2026.
Naringin and naringenin exhibit well‐recognized therapeutic potential; however, they face limitations related to solubility and bioavailability. Micronization increases surface area and enhances absorption. Notably, cocrystallization stands out as a primary strategy for particle optimization, as it refines physicochemical properties, improves ...
Emilia Rodrigues Almeida, Kanandra Taisa Bertoncello, Ketelin Zamin Kuhn, Liz Girardi Müller, J. Vladimir Oliveira   +4 more
wiley   +1 more source

Is Nonmicronized Diosmin 600 mg as Effective as Micronized Diosmin 900 mg plus Hesperidin 100 mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study

International Journal of Vascular Medicine, 2020
Background. Phlebotonics have beneficial effects on some symptoms related to chronic venous disease (CVD) of the lower limbs. The most commonly used one is diosmin, available in a pure semisynthetic form or as a micronized purified flavonoid fraction ...
Marcio Steinbruch, Carlos Nunes, Romualdo Gama, Renato Kaufman, Gustavo Gama, Mendel Suchmacher Neto, Rafael Nigri, Natasha Cytrynbaum, Lisa Brauer Oliveira, Isabelle Bertaina, François Verrière, Mauro Geller   +11 more
doaj   +1 more source