Results 221 to 230 of about 178,962 (375)

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Analysis of the Combined Effects of a Novel Combination of Hypersmin, Pumpkin Seed and Amaranthus Extracts in an In Vitro Model of Chronic Venous Insufficiency. [PDF]

Nutrients
Ferrari S, Galla R, Mulè S, Molinari C, Uberti F.   +4 more
europepmc   +1 more source

Case Report: Successful results of direct varicose vein ablation with EVLA in chronic venous insufficiency patient in Indonesia. [PDF]

F1000Res, 2023
Taofan T, Utoh J, Dakota I, Indriani S, Abdillah C, Kartamihardja AHA, Adiarto S, Sukmawan R.   +7 more
europepmc   +1 more source

Photothermal–Immunomodulatory Hydrogel Reinforced by Ti3C2/ZnAl‐LDH Nanoplatform for Eradicating MRSA and Promoting Diabetic Wound Healing

Advanced Science, EarlyView.
A NETs‐inspired Ti3C2/LDH hydrogel integrates trapping, ROS boosting, and M2‐immunomodulation for MRSA‐infected wound repair. ABSTRACT MRSA infections give rise to chronic cutaneous and advance into profound tissue invasions, including osteomyelitis and sepsis—conditions for which existing clinical interventions offer only limited efficacy. The utility
Qiang Shi, Renliang Zhao, Jia Wang, Zhenchen Xiong, Xiangtian Deng, Cheng Zheng, Wenzhi Zhang   +6 more
wiley   +1 more source

Minimally invasive management of chronic venous insufficiency: A case report on combined radiofrequency ablation and sclerotherapy in an obese patient. [PDF]

Int J Surg Case Rep
La Marca MA, Bruno S, Dinoto E, Federico R, Pecoraro F, Mirabella D.   +5 more
europepmc   +1 more source

Concentrations of selected acute phase proteins in patients with chronic venous insufficiency treated with Sulodexide. Part 1. [PDF]

Postepy Dermatol Alergol, 2023
Kaczmarek B, Kozłowska M, Narbutt J, Adamski Z, Adamska K, Kaszuba A.   +5 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Nutritional Status in a Group of Patients with Wounds Due to Diabetic Foot Disease and Chronic Venous Insufficiency. [PDF]

J Clin Med
Skórka M, Bazaliński D, Więch P, Kłęk S, Kozieł D, Sierżantowicz R.   +5 more
europepmc   +1 more source

A prospective study on hyperhomocysteinemia as an aggravating factor in chronic venous insufficiency. [PDF]

Exp Ther Med, 2022
Rotaru M, Mariana Iancu G, Baldovin I.
europepmc   +1 more source

Chronic cerebrospinal venous insufficiency: masked multimodal imaging assessment [PDF]

, 2013
Staley A. Brod, Larry A. Kramer, Alan M. Cohen, Andrew D. Barreto, Thanh‐Tung Bui, J. Jemelka, K. Ton, John Lindsey, Flavia Nelson, Ponnada A. Narayana, Jerry S. Wolinsky   +10 more
openalex   +1 more source