Results 101 to 110 of about 237,116 (358)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Topical agents or dressings for pain in venous leg ulcers. [PDF]

, 2010
Venous leg ulcers affect up to 1% of people at some time in their lives and are often painful. The main treatments are compression bandages and dressings.
Briggs, M, Nelson, EA, Martyn-St James, M   +2 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Generating and Reversing Chronic Wounds in Diabetic Mice by Manipulating Wound Redox Parameters

Journal of Diabetes Research, 2014
By 2025, more than 500 M people worldwide will suffer from diabetes; 125 M will develop foot ulcer(s) and 20 M will undergo an amputation, creating a major health problem.
Sandeep Dhall, Danh C. Do, Monika Garcia, Jane Kim, Seyed H. Mirebrahim, Julia Lyubovitsky, Stefano Lonardi, Eugene A. Nothnagel, Neal Schiller, Manuela Martins-Green   +9 more
doaj   +1 more source

Lifetime glucocorticoid profiles in baleen of right whale calves: Potential relationships to chronic stress of repeated wounding by Kelp Gulls [PDF]

, 2018
Baleen tissue accumulates stress hormones (glucocorticoids, GC) as it grows, along with other adrenal, gonadal and thyroid hormones. The hormones are deposited in a linear fashion such that a single plate of baleen allows retrospective assessment and ...
Ajó, Alejandro A. Fernández, Buck, Charles Loren, Di Martino, Matias, Hunt, Kathleen E., Marón, Carina Flavia, Rowntree, Victoria, Sironi, Mariano, Uhart, Marcela María   +7 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Systemic infection with single or multi-organ damage caused by inadequately managed chronic wounds: a case series

Acta Clinica Croatica, 2022
Chronic wounds are often underestimated condition with increasingly growing inpatient and outpatient treatment costs. Since the patient population affected by chronic wounds is heterogeneous and includes diabetes, chronic venous insufficiency and ...
Điđi Delalić, Robert Roher, Dean Mileta, Ingrid Prkačin   +3 more
doaj  

Why honey is effective as a medicine. 1. Its use in modern medicine [PDF]

, 1999
Honey has been used as a medicine for thousands of years and its curative properties are well documented. However, modern medicine turned its back on honey and it is only now, with the advent of multi-resistant bacteria, that the antibiotic properties of
ADESUNKANMI K, AL-SWAYEH O A, ALI A T M, ALI A T M M, ALI A T M M, AMERICAN BEE JOURNAL, ANKRA-BADU G A, ARISTOTLE (350 BC), ARMON P J, BLOOMFIELD E, BRANIKI F J, BULMAN M W, BURLANDO F, CELSUS, CONDON R E, DANY-MAZEAU M, DANY-MAZEAU M P G, DESCOTTES B, DUMRONGLERT E, EFEM S E E, EL-BANBY M, EMARAH M H, FORREST R D, FOTIDAR M R, GUPTA S K, HAMDY M H, HARRIS S, HUTTON D J, IMPERATO P J, KANDIL A, KANDIL A, KAUFFMAN G B, KHOTKINA M L, KUMAR A, LINNETT P, LÜCKE H, McINERNEY R J F, MEN'SHIKOV F K, MLADENOV S, MOLAN P, MOLAN P C, MOLAN P C, MOZHERENKOV V P, NDAYISABA G, OBI C L, OSAULKO G K, PHILLIPS C E, POPESCU M P, SALEM S N, SARMA M C, SEYMOUR F I, SLOBODIANIUK A A, SOMERFIELD S D, SOUTH AFRICAN MEDICAL JOURNAL, THOMPSON W A R, TOVEY F I, VOIGTLÄNDER H, WADI M, WEBER H, WEHEIDA S M, WOOD B, YANG K L, ZAIß, ZUMLA A   +63 more
core   +2 more sources