Results 111 to 120 of about 237,116 (358)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Natural history study of recessive dystrophic epidermolysis bullosa wounds and patient reported outcomes using mobile application home photography

Scientific Reports
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare, blistering genetic disease where wounding and wound pain are the most reported problems by patients.
Shivali Fulchand, Jaron Nazaroff, Nicki Harris, Jodi Y. So, Ricardo Villanueva Gaona, Estephannie Alvarez, Shufeng Li, Ying Lu, Edward Eid, Jean Y. Tang   +9 more
doaj   +1 more source

Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing

Frontiers in Bioengineering and Biotechnology, 2016
Wound healing is an intricate process that requires complex coordination between many cells and an appropriate extracellular microenvironment. Chronic wounds often suffer from high protease activity, persistent infection, excess inflammation, and hypoxia.
Subhamoy Das, Aaron Baker
doaj   +1 more source

Using honey to heal diabetic foot ulcers [PDF]

, 2008
Diabetic ulcers seem to be arrested in the inflammatory/proliferative stage of the healing process, allowing infection and inflammation to preclude healing.
Aaltonen, LA, Ballereau, S, Barclay, E, Broderick, P, Campbell, H, Carvajal-Carmona, LG, Casey, G, Cazier, JB, Chander, I, Cheadle, JP, Conti, D, Deary, I, Dobbins, SE, Domingo, E, Duggan, DJ, Dunlop, MG, Easton, D, Farrington, SM, Frampton, M, Gallinger, S, Gorman, M, Grimes, G, Henrion, M, Hopper, J, Houlston, RS, Jenkins, MA, Jones, AM, Kerr, DJ, Kirac, I, Kovacević, D, Lindblom, A, Liu, T, Lloyd, A, Lubbe, S, Ma, YP, Martin, L, Matsuda, K, Mecklin, JP, Midgley, R, Nakamura, Y, Newcomb, P, Okada, Y, Olver, B, Ooi, LY, Palles, C, Penegar, S, Pharoah, P, Prendergast, J, Renkonen-Sinisalo, L, Rudan, I, Schumacher, F, Semple, C, Shah, M, Smillie, C, Smith, CG, Spain, S, Starr, JM, Tenesa, A, Theodoratou, E, Tomlinson, IP, Vijayakrishnan, J, West, H, Whiffin, N, Zgaga, L   +63 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Calciphylaxis as A Rare Cause of A Chronic Wound in An 83-Year-Old Woman

Geriatrics, 2019
Chronic wounds are common in elderly patients, and the majority of them are caused by vascular diseases, such as peripheral arterial occlusive disease (PAD) or chronic venous insufficiency.
Stefan Dörr, Gregor Weisser, Ralf Lobmann   +2 more
doaj   +1 more source

The Efficacy of Pressure Ulcer Treatment With Cathodal and Cathodal-Anodal High-Voltage Monophasic Pulsed Current: A Prospective, Randomized, Controlled Clinical Trial [PDF]

, 2017
Background. Studies show that anode and cathode electrical stimulation (ES) promotes the healing of wounds, but specific protocols for both electrodes are not available. Objective. To compare the effectiveness of cathodal versus cathodal+anodal ES in the
Blaszczak, Edward, Franek, Andrzej, Hordynska, Ewa, Ickowicz, Tomasz, Kloth, Luther C., Kucio, Cezary, Nawrat-Szoltysik, Agnieszka, Polak, Anna, Taradaj, Jakub   +8 more
core   +2 more sources

Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration: Erratum

, 2021
Chenggui Wang, Min Wang, Tianzhen Xu, Xingxing Zhang, Cai Lin, Weiyang Gao, Huazi Xu, Bo Lei, Cong Mao   +8 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Results of hyperbaric oxygenation in chronic wound healing – preliminary findings

Studia Medyczne, 2016
Introduction: Improved wound healing decreases the risk of complications, increases the possibilities of further treatment, rehabilitation, and care, and improves the quality of life for the patients. Aim of the research: The aim of this paper is to
Piotr Dzięgielewski, Emilia Mikołajewska, Aleksander Goch   +2 more
doaj   +1 more source