Results 111 to 120 of about 121,354 (286)

DEPLOYING INTEGRATED CARE MODELS FOR FRAIL ELDERLY PATIENTS

International Journal of Integrated Care, 2015
Marisa Merino, Mariluz Marqués, Marivi Egurbide, Maribel Romo, Isabel Rodríguez, Marbella García, Sara Ponce, Ane Fullaondo, Joana Mora, Esteban de Manuel   +9 more
doaj   +3 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Healing waters: Medicine, Chemistry, Relief and Extraordinary Cures in Britain in the Long Eighteenth Century

Etudes Epistémè
This article focuses on the use and theories of mineral waters to explore how healing can be understood as a multifaceted phenomenon by doctors and patients alike. In medical theory and practice around taking the waters, health improvements were expected
Sophie Vasset
doaj   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Relating Severe Poverty and Chronic Poverty [PDF]

The severely poor are very poor since their consumption is far below the absolute poverty line, and the chronically poor are very poor since their consumption persists for long periods below the absolute poverty line. A combination of chronic poverty and
Shahin Yaqub
core  

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

A cornerstone of healthy aging: do we need to rethink the concept of adherence in the elderly?

Patient Preference and Adherence, 2018
Anna Giardini,1 Marina Maffoni,2 Przemyslaw Kardas,3 Elisio Costa4 1Psychology Unit, Istituti Clinici Scientifici Maugeri Spa SB, IRCSS Montescano, Montescano (PV), Italy; 2Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy;
Giardini A, Maffoni M, Kardas P, Costa E
doaj  

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Impacto da cronicidade do transtorno distímico na qualidade de vida

Estudos de Psicologia (Campinas)
A distimia diferencia-se da depressão por sua cronicidade e menor severidade sintomatológica. A cronicidade acarreta sérios prejuízos na rotina dos pacientes, atividades laborais, relacionamentos sociais e qualidade de vida.
Mara Rúbia de Camargo Alves Orsini, Cecília Rodrigues Ribeiro   +1 more
doaj   +1 more source