Results 51 to 60 of about 63,781 (241)

Psychosocial Predictors of Self-Efficacy Related to Self-Reported Adherence in Older Chronic Patients Dealing with Hypertension: A European Study

Patient Preference and Adherence, 2020
Francesco Zanatta,1 Ekaterina Nissanova,1 Natalia Świątoniowska-Lonc,2 Antonia Pierobon,1 Giovanna Callegari,3 Francesca Olmetti,4 Guido Felicetti,5 Piotr Karniej,2 Jacek Polański,6 Anna Giardini,7 Beata Jankowska-Polańska2 1Psychology Unit of Montescano
Zanatta F, Nissanova E, Świątoniowska-Lonc N, Pierobon A, Callegari G, Olmetti F, Felicetti G, Karniej P, Polański J, Giardini A, Jankowska-Polańska B   +10 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Reliability and Validity of the KFORCE Sens^® Inertial Sensor for Measuring Cervical Spine Proprioception in Patients with Non-Specific Chronic Neck Pain

Brain Sciences
Background/Objectives: Patients with non-specific chronic neck pain (NSCNP) exhibit sensorimotor disturbances, with proprioception impairment considered an important aspect.
George A. Koumantakis, Stamatina Gkouma, Christina Floka, Petros I. Tatsios, Maria Moutzouri, Vasiliki Sakellari   +5 more
doaj   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Sclerotic disease, integrative diagnosis, chronic forms and treatment of diseases [PDF]

Саратовский научно-медицинский журнал, 2015
The aim of the article is to determine the importance of an integrative approach to identify and analyze the phases or stages of the example of chronic sclerotic disease (CSD). The proposed concept of CSD is to use the diagnostic methods before sclerotic
Kats Ya.A., Parkhoniuk E.V., Skriptsova S.A.   +2 more
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Opinions and perceptions of patients with cardiovascular disease on adherence: a qualitative study of focus groups

BMC Primary Care
Background Cardiovascular diseases are becoming more frequent throughout the world. Adherence to both pharmacological and non-pharmacological treatment, as well as lifestyles, is important for good management and control of the disease.
Álvaro Carbonell-Soliva, Rauf Nouni-García, Adriana López-Pineda, Alberto Cordero-Fort, Virtudes Pérez-Jover, Jose A. Quesada, Domingo Orozco-Beltrán, Andreu Nolasco, Jose Maria Castellano-Vázquez, Jose Joaquín Mira-Solves, Vicente F. Gil-Guillen, Concepción Carratala-Munuera   +11 more
doaj   +1 more source

Safety and immunogenicity of the therapeutic vaccine TG1050 in chronic hepatitis B patients: a phase 1b placebo-controlled trial

Human Vaccines & Immunotherapeutics, 2020
Treatment of chronic hepatitis B (CHB) typically requires life-long administration of drugs. Cohort and pre-clinical studies have established the link between a functional T-cell-mounted immunity and resolution of infection.
Fabien Zoulim, Claire Fournier, François Habersetzer, Martin Sprinzl, Stanislas Pol, Carla S Coffin, Vincent Leroy, Mang Ma, Heiner Wedemeyer, Ansgar W Lohse, Robert Thimme, Karine Lugardon, Perrine Martin, Bérangère Bastien, Benoit Sansas, Nathalie Adda, Celine Halluard, Kaïdre Bendjama, Maud Brandely, Geneviève Inchauspé   +19 more
doaj   +1 more source