Results 41 to 50 of about 1,235 (252)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Simulation Analysis of Meshing Gear Churning Power Loss based on CFD Method
Jixie chuandong, 2018 It is difficult to determine the gear churning power loss directly by theoretical methods because gear churning power loss has a complex relationship with its influencing factors.
Shen Lin, Ruan Dengfang, Tu Pan
doaj
Analysis of Gear Oil Churning Power Loss and Transmission Efficiency of Reducer
Jixie chuandong, 2020 Aiming at the reducer of pure electric vehicle，the gear churning power loss is analyzed based on ParticleWorks software，and the characteristics of gear churning power loss are explored.
Guangze Zheng +3 more
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
Research on the Power Loss of High-Speed and High-Load Ball Bearing for Cryogenic Turbopump
Machines, 2022 This paper studies the lubrication characteristics of ball bearings for cryogenic turbopumps. First, the frictional coefficients between 440C and a Ag coating, 440C and solid PTFE (polytetrafluoroethylene), and 440C and a PTFE coating in LN2 (liquid ...
Wenhu Zhang +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source
LubricantsTo investigate the lubrication characteristics in high-speed train gearboxes, a two-stage herringbone gearbox with an idle gear was analyzed. The lubricant flow and distribution were shown using the moving particle semi-implicit (MPS) method.
Shuai Shao +6 more
doaj +1 more source
Research On The Influence Of The Piston Number On The Churning Losses In Axial Piston Pumps [PDF]
, 2021 Abstract The piston is a key rotating component in the axial piston pump, and its churning losses will reduce the performance and efficiency. To improve the performance and efficiency of the axial piston pump, a computational fluid dynamics (CFD) simulation model of churning loss was established, and the effect of piston number on the churning ...
Ying Li +4 more
openaire +1 more source