Results 51 to 60 of about 7,125,299 (256)

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

A NOTE ON FLOW REGIMES AND CHURNING LOSS MODELLING

, 2011
International audienceThe purpose of this study is to investigate the various fluid flow regimes generated by a pinion running partly immersed in an oil bath and the corresponding churning power losses. In a series of papers, the authors have established
Velex, Philippe, Changenet, Christophe, Ville, Fabrice, Leprince, Gauthier   +3 more
core   +3 more sources

Churning power losses of ordinary gears: a new approach based on the internal fluid dynamics simulations

Lubrication Science, 2014
AbstractThe increasing need of more and more efficient gearboxes implies the need of predictive models in order to compare, during the design stage, different design solutions. The models provided by literature are mostly experimentally derived and not accurate on real applications. A new trend suggests the adoption of computational fluid dynamics (CFD)
CONCLI, FRANCO, GORLA, CARLO, DELLA TORRE, AUGUSTO, MONTENEGRO, GIANLUCA   +3 more
openaire   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Thermodynamic Pathways of Nonequilibrium Solidification in Wire‐Arc Additive Manufacturing Fe‐Based Multicomponent Alloy Structures

Advanced Engineering Materials, EarlyView.
Geometry‐driven thermal behavior in wire‐arc additive manufacturing (WAAM) influences microstructural evolution during nonequilibrium solidification of a chemically complex Fe–Cr–Nb–W–Mo–C nanocomposite system. By comparing different deposits configurations, distinct entropy–cooling rate correlations, segregation, and carbide evolution are revealed ...
Blanca Palacios, Anthony Gonzalez, Aleksander Aleman, Tyler Dolmetsch, Tanaji Paul, Arvind Agarwal   +5 more
wiley   +1 more source

Influence of lubricant temperature, lubricant level and rotational speed on the churning power loss in an industrial planetary speed reducer: computational and experimental study [PDF]

International Journal of Computational Methods and Experimental Measurements, 2013
Planetary speed reducers are applied in a wide range of applications. Their main advantages are the compact design and high power density. For this reason, the demand for high effi ciency gearboxes is continuously increasing and this is also why models to predict the additional churning loss, characteristic of this kind of gearing, are required.
Concli, Franco, Gorla, Carlo
openaire   +2 more sources

A Simplified Laminar Flow Model for the Pultrusion of Glass Fiber/Polyethylene Terephthalate Commingled Yarns

Advanced Engineering Materials, EarlyView.
A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares, Nadège Bouchonneau, Christian Jochum, Donald Radford   +3 more
wiley   +1 more source

Quantifying Dynamic Oil Immersion in a Spiral Bevel Gear via Image Processing for Improved Churning Loss Prediction

Lubricants
This paper investigates the special phenomenon that the practical immersed depth of a spiral bevel gear as the driving gear under splash lubrication is significantly less than the static depth.
Yu Dai, Xin Huang, Jianfeng Zhong, Caihua Yang, Xiang Zhu   +4 more
doaj   +1 more source