Results 31 to 40 of about 23,962 (275)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Thermal Performance Evaluation in Gas Turbine Aero Engines Accessory Gearbox

International Journal of Turbomachinery, Propulsion and Power, 2020
This paper presents a methodological approach for mathematical modelling and physics-based analysis of accessory gearbox (AGB) thermal behavior in gas turbine aero engines. The AGB structure, as one of the main sources of heat in gas turbine aero engines,
Soheil Jafari, Ahmed Bouchareb, Theoklis Nikolaidis   +2 more
doaj   +1 more source

Influence of lubricant type on churning power loss of worm gear

Tribology and Materials
This paper presents the results of experimental tests of the churning power loss of a single-stage worm gear. The churning power loss is a load-independent loss that occurs when the gear churns through the lubricant. This study will solely look at how churning power losses are affected by mineral and synthetic oil on a test worm gear pair where the ...
Hardik G. Chothani, Devendra J. Marsonia, Nisha N. Jadeja, Sanjay H. Zala, Ketan S. Vaghosi   +4 more
openaire   +2 more sources

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Analytical and Experimental Investigation of Windage–Churning Behavior in Spur, Bevel, and Face Gears

Applied Sciences
This paper presents comparable sets of the no-load power loss as a product of windage and churning behaviors of a family of various rotating parts (i.e., disc, spur gear, straight bevel gear, and orthogonal face gear).
Yu Dai, Caihua Yang, He Liu, Xiang Zhu
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Improving efficiency in drive lines : an experimental study on churning losses in hypoid axle

, 2010
The research concerns improvement of the power efficiency of lubricated components in automotive drivelines such as transmissions and axles. Meshed gear pairs, rolling bearings, seals and oil churning by rotating components immersed in the oil are ...
Jeon, Soo Il, Jeon, Soo Il
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Simulation and experimental study of influences of shape of roller on the lubrication performance of precision speed reducer

Engineering Applications of Computational Fluid Mechanics, 2020
This paper presents a study to investigate the effects of the shape of rollers in high precision enveloping speed reducer on the reducer’s lubrication performance. Theoretical models for the precision speed reducer with cylindrical and conical rollers as
Xingqiao Deng, Shisong Wang, Linmao Qian, Yucheng Liu   +3 more
doaj   +1 more source