Results 11 to 20 of about 14,726 (218)
The Biogenesis of Chylomicrons [PDF]
Annual Review of Physiology, 2010 The absorption of dietary fat is of increasing concern given the rise of obesity not only in the United States but throughout the developed world. This review explores what happens to dietary fat within the enterocyte. Absorbed fatty acids and monoacylglycerols are required to be bound to intracellular proteins and/or to be rapidly converted to ...
C. M. Mansbach, Shadab A. Siddiqi
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Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 66, Issue 24, December 2022., 2022 Duodenal mucosa in early‐stage type 2 diabetes mellitus (ED), late‐stage type 2 diabetes mellitus injected with streptozotocin‐nicotinamide (STZ/NAD) (LD) and treated‐silicon LD (LD‐Si) groups. Silicon partially reversed LD group alterations: decreased absorptive area and acyl‐Coenzyme A:cholesterol acyltransferase 2 (ACAT2) levels, and increased ...
Marina Hernández‐Martín +9 more
wiley +1 more source
The Chylomicron: Relationship to Atherosclerosis [PDF]
International Journal of Vascular Medicine, 2012 The B-containing lipoproteins are the transporters of cholesterol, and the evidence suggests that the apo B48-containing postprandial chylomicron particles and the triglyceride-rich very low density lipoprotein (VLDL) particles play an important part in the development of the plaque both directly and indirectly by their impact on LDL composition.
Gerald H. Tomkin, Daphne Owens
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Genotype‐driven NPC1L1 and PCSK9 inhibition and reduced risk of periodontitis
Journal of Clinical Periodontology, Volume 50, Issue 1, Page 114-120, January 2023., 2023 Abstract Aim Epidemiological and pre‐clinical studies suggest a chemoprotective role of lipid‐lowering agents in periodontitis. We tested the association of genetically proxied inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase (HMGCR), Niemann‐Pick C1‐Like 1 (NPC1L1) and proprotein convertase subtilisin/kexin type 9 (PCSK9) with ...
Sebastian‐Edgar Baumeister +7 more
wiley +1 more source
Comparison of the metabolism of chylomicrons and chylomicron remnants by the perfused liver [PDF]
Biochemical Journal, 1978 1. The hepatic metabolism of chylomicrons and chylomicron remnants was compared after adding approximately equal numbers of each lipoprotein particle to the perfusate of isolated livers. 2. At least 40% of the added remnants were metabolized by the liver compared with less than 3% for chylomicrons. 3.
P A Mayes, R S Gardner
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Journal of Lipid Research, 1997 The size of cholesterol-rich lipoprotein particles is a strong determinant of whether they may be deposited in the arterial wall and by this become potentially atherogenic. This study deals with the in vivo transformation of larger-sized chylomicrons and chylomicron remnants to smaller-sized remnants. Twelve healthy men aged 22 to 45 years were given a
Karpe, F +3 more
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Hepatic uptake of chylomicron remnants
Journal of Lipid Research, 1997 Chylomicrons are formed in the intestine and transport dietary triglyceride to peripheral tissues and cholesterol to the liver. The enzyme lipoprotein lipase, with apolipoprotein (apo)C-II as a co-factor, hydrolyzes chylomicron triglyceride allowing the delivery of free fatty acids to muscle and adipose tissue.
A D Cooper
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Effects of chylomicrons and chylomicron remnants on endothelium-dependent relaxation of rat aorta [PDF]
European Journal of Pharmacology, 1998 The effects of chylomicrons and chylomicron remnants on endothelium-dependent relaxation of rat aorta were studied in vitro. Chylomicrons and chylomicron remnants were prepared in vivo. Aortic rings were incubated with the lipoproteins for 45 min before the vessels were constricted with phenylephrine and concentration relaxation response curves ...
Grieve, David +3 more
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Chemistry &Biodiversity, EarlyView.Hypolipidemic influence of CETZ.2HCl‐(H1‐antihistamine) metal‐complexes on “C57Bl/6‐mice” fed high‐fat‐diet. ABSTRACT New Cd(II), Zn(II), and Cu(II) chelates with cetirizine.2HCl (CETZ.2HCl) in incidence of 1,10 phenanthroline monohydrate (Phen.H2O) were synthesized in search of new biologically active compounds.
Sherif M. Abd El‐Hamid +10 more
wiley +1 more source