Results 1 to 10 of about 19,423 (204)

Chylomicron/chylomicron remnant turnover in humans: evidence for margination of chylomicrons and poor conversion of larger to smaller chylomicron remnants

Journal of Lipid Research, 1997
The size of cholesterol-rich lipoprotein particles is a strong determinant of whether they may be deposited in the arterial wall and by this become potentially atherogenic. This study deals with the in vivo transformation of larger-sized chylomicrons and
F Karpe, T Olivecrona, A Hamsten, M Hultin   +3 more
doaj   +6 more sources

The Chylomicron: Relationship to Atherosclerosis [PDF]

International Journal of Vascular Medicine, 2012
The B-containing lipoproteins are the transporters of cholesterol, and the evidence suggests that the apo B48-containing postprandial chylomicron particles and the triglyceride-rich very low density lipoprotein (VLDL) particles play an important part in the development of the plaque both directly and indirectly by their impact on LDL composition.
Gerald H. Tomkin, Daphne Owens
core   +6 more sources

Intestinal basolateral lipid substrate transport is linked to chylomicron secretion and is regulated by apoC-III

Journal of Lipid Research, 2019
Chylomicron metabolism is critical for determining plasma levels of triacylglycerols (TAGs) and cholesterol, both of which are risk factors for CVD.
Diana Li, Minkyung Bae
exaly   +3 more sources

The chylomicron saga: time to focus on postprandial metabolism

Frontiers in Endocrinology
Since statins have had such tremendous therapeutic success over the last three decades, the field of atherosclerosis has become somewhat LDL-centric, dismissing the relevance of triglycerides (TG), particularly chylomicrons, in atherogenesis. Nonetheless,
Alejandro Gugliucci, Gugliucci Alejandro   +1 more
exaly   +3 more sources

The Biogenesis of Chylomicrons [PDF]

Annual Review of Physiology, 2010
The absorption of dietary fat is of increasing concern given the rise of obesity not only in the United States but throughout the developed world. This review explores what happens to dietary fat within the enterocyte. Absorbed fatty acids and monoacylglycerols are required to be bound to intracellular proteins and/or to be rapidly converted to ...
Charles M, Mansbach, Shadab A, Siddiqi
openaire   +3 more sources

Evidence that chylomicron remnants and beta-VLDL are transported by the same receptor pathway in J774 murine macrophage-derived cells.

Journal of Lipid Research, 1990
To characterize lipoprotein uptake by macrophages, we studied J774 murine macrophage-derived cells. Uptake of 125I-labeled beta-VLDL and 125I-labeled chylomicron remnants was saturable, specific, and of high affinity.
J L Ellsworth, A D Cooper, F B Kraemer
doaj   +1 more source

Comparison of the metabolism of chylomicrons and chylomicron remnants by the perfused liver [PDF]

Biochemical Journal, 1978
1. The hepatic metabolism of chylomicrons and chylomicron remnants was compared after adding approximately equal numbers of each lipoprotein particle to the perfusate of isolated livers. 2. At least 40% of the added remnants were metabolized by the liver compared with less than 3% for chylomicrons. 3.
R S, Gardner, P A, Mayes
openaire   +2 more sources

Consumption of low doses of fat prevents the postprandial rise in chylomicron particle concentration and remnant accumulation in healthy normolipidaemic males

Journal of Nutritional Science, 2012
Chylomicron particles are continually synthesised and secreted from the intestine even in the absence of ingested fat. It is possible that following consumption of low doses of fat the basal level of chylomicron secretion and subsequent metabolism are ...
Anthony P. James, John C. Mamo
doaj   +1 more source

Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver.

Journal of Lipid Research, 1994
The participation of hepatic lipase in the initial uptake and processing of chylomicron remnants was studied in the isolated, perfused rat liver. Hepatic lipase activity was either reduced by preperfusion of livers with heparin or inhibited with specific
S Shafi, S E Brady, A Bensadoun, R J Havel   +3 more
doaj   +1 more source

Metabolism of chylomicrons by the isolated rat liver

Journal of Lipid Research, 1967
Isolated livers perfused with washed corn oil chylomicrons labeled in vivo with palmitic acid-1-14C removed a large proportion of the chylomicrons. Slices from these livers oxidized chylomicron fatty acid esters to both carbon dioxide and acetoacetate ...
Joseph A. Ontko, D.B. Zilversmit
doaj   +1 more source