Results 41 to 50 of about 26,251 (228)

Ezetimibe therapy: mechanism of action and clinical update. [PDF]

, 2012
The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in the primary and secondary prevention of cardiovascular events.
Dayspring, Thomas D, Phan, Binh An P, Toth, Peter P   +2 more
core   +1 more source

Low and high responders to pharmacological doses of β-carotene: proportion in the population, mechanisms involved and consequences on β-carotene metabolism

Journal of Lipid Research, 1998
The aim of this study was to assess the interindividual variability of chylomicron β-carotene response to a pharmacological load of β-carotene in the population, to identify the mechanisms responsible for this variability, and to evaluate its ...
Patrick Borel, Pascal Grolier, Nadia Mekki, Yves Boirie, Yvanne Rochette, Brigitte Le Roy, Marie C. Alexandre-Gouabau, Denis Lairon, Véronique Azais-Braesco   +8 more
doaj   +1 more source

Vitamin E as a Treatment for Nonalcoholic Fatty Liver Disease: Reality or Myth? [PDF]

, 2018
Obesity is one of the major epidemics of this millennium, and its incidence is growing worldwide. Following the epidemics of obesity, nonalcoholic fatty liver disease (NAFLD) has become a disease of increasing prevalence and a leading cause of morbidity ...
El Hadi, Hamza, Rossato, Marco, Vettor, Roberto   +2 more
core   +2 more sources

Chylomicron catabolism differs between Hooded and albino laboratory rats.

Journal of Lipid Research, 1982
To extend previous reports that some aspects of lipid metabolism are different between Hooded and albino strains of laboratory rats, thoracic duct lymph chylomicrons were collected and their composition and metabolism were compared in this study ...
F Jeffery, T G Redgrave
doaj   +1 more source

Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E

Journal of Lipid Research, 2000
Apolipoprotein E (apoE) is a ligand for the low density lipoprotein receptor (LDLR) and the low density lipoprotein receptor-related protein (LRP). The aim of the present study was to clarify the role of hepatically localized apoE in the rapid initial ...
Kenneth C-W. Yu, Yuan Jiang, Wei Chen, Allen D. Cooper   +3 more
doaj   +1 more source

Differences in apolipoprotein and lipid composition between human chylomicron remnants and very low density lipoproteins isolated from fasting and postprandial plasma

Journal of Lipid Research, 1998
Triglyceride-rich lipoproteins (TRLs) that are modified during alimentary lipemia and their remnants are indicated to play an important role in the development of atherosclerosis.
Johan Björkegren, Fredrik Karpe, Ross W. Milne, Anders Hamsten   +3 more
doaj   +1 more source

Apolipoprotein CIII predicts cardiovascular events in patients with coronary artery disease: a prospective observational study

Lipids in Health and Disease, 2020
Background Apolipoprotein CIII (apoCIII) is associated with triglyceride-rich lipoprotein metabolism and has emerged as independent marker for risk of cardiovascular disease.
Julius L. Katzmann, Christian M. Werner, Tatjana Stojakovic, Winfried März, Hubert Scharnagl, Ulrich Laufs   +5 more
doaj   +1 more source

Effects of cholesterol in chylomicron remnant models of lipid emulsions on apoE-mediated uptake and cytotoxicity of macrophages

Journal of Lipid Research, 2005
Chylomicron remnants have been suggested to be involved in the development of atherosclerosis. To investigate the mechanisms of chylomicron remnant-induced atherosclerosis, we prepared cholesterol (Chol)-containing emulsion particles as models for ...
Atsushi Sakurai, Shin-ya Morita, Kyoko Wakita, Yuko Deharu, Minoru Nakano, Tetsurou Handa   +5 more
doaj   +1 more source

Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice [PDF]

, 1994
To investigate the role of apoE in hepatic uptake of chylomicron remnants, we studied chylomicron metabolism in transgenic mice overexpressing apoE in the liver.
Gotoda T, Harada K, Kawamura M, Namba Y, Ohsuga J, Shimada M, Shimano H, Yamada N, Yamamoto K, Yazaki Y, 山田 信博   +10 more
core   +1 more source

Chylomicron metabolism in rats: lipolysis, recirculation of triglyceride-derived fatty acids in plasma FFA, and fate of core lipids as analyzed by compartmental modelling

Journal of Lipid Research, 1996
Chylomicrons labeled in vivo with [14C]oleic acid (primarily in triglycerides (TG), providing a tracer for lipolysis) and [3H]retinol (primarily in ester form, providing a tracer for the corelipids) were injected into rats.
M Hultin, R Savonen, T Olivecrona
doaj   +1 more source