Results 51 to 60 of about 17,950 (189)

Protein Kinase D2 drives chylomicron‐mediated lipid transport in the intestine and promotes obesity

EMBO Molecular Medicine, 2021
Lipids are the most energy‐dense components of the diet, and their overconsumption promotes obesity and diabetes. Dietary fat content has been linked to the lipid processing activity by the intestine and its overall capacity to absorb triglycerides (TG).
Jonathan Trujillo‐Viera, Rabih El‐Merahbi, Vanessa Schmidt, Till Karwen, Angel Loza‐Valdes, Akim Strohmeyer, Saskia Reuter, Minhee Noh, Magdalena Wit, Izabela Hawro, Sabine Mocek, Christina Fey, Alexander E Mayer, Mona C Löffler, Ilka Wilhelmi, Marco Metzger, Eri Ishikawa, Sho Yamasaki, Monika Rau, Andreas Geier, Mohammed Hankir, Florian Seyfried, Martin Klingenspor, Grzegorz Sumara   +23 more
doaj   +1 more source

From Congenital Disorders of Fat Malabsorption to Understanding Intra-Enterocyte Mechanisms Behind Chylomicron Assembly and Secretion

Frontiers in Physiology, 2021
During the last two decades, a large body of information on the events responsible for intestinal fat digestion and absorption has been accumulated. In particular, many groups have extensively focused on the absorptive phase in order to highlight the ...
Emile Levy, Emile Levy, Emile Levy, Jean François Beaulieu, Schohraya Spahis, Schohraya Spahis   +5 more
doaj   +1 more source

Fatty acid esterification and chylomicron formation during fat absorption: 2. Phospholipids

Journal of Lipid Research, 1963
Studies were conducted on the over-all fatty acid specificity of the mechanisms involved in chylomicron lecithin formation during fat absorption in the rat.
Malcolm Whyte, Arthur Karmen, DeWitt S. Goodman   +2 more
doaj   +1 more source

The genetic landscape of congenital diarrheas and very early onset inflammatory bowel disease in the Middle East

JPGN Reports, EarlyView.
Abstract Objectives Monogenic causes of congenital diarrheas and enteropathies (CoDE) and very early onset inflammatory bowel disease (VEOIBD) are mostly recessive and therefore more prevalent in populations with increased consanguinity rates. To assess the genetic basis of these disorders in a likely high‐prevalence population, we established a multi ...
Lily Gillette, Muna Al Safar, Ganeshwaran H. Mochida, Casey Johnson, Stephen Babcock, Klaus Schmitz‐Abe, Michael Field, Jessica Yang, Richelle Bearup, Ahmed Megahed, Mohammed Ezz El Regal Abbas, Tarek Baraket, Sherine Elziny, Ali Sobh, Gulin Eren, Fawaz AlRefaee, Rana Bitar, Mohamed Miqdady, Pankaj B. Agrawal, Scott B. Snapper, Jay R. Thiagarajah, Jodie Ouahed   +21 more
wiley   +1 more source

Chylomicron apoprotein localization within rat intestinal epithelium: studies of normal and impaired lipid absorption1

Journal of Lipid Research, 1978
Monospecific antisera were produced to two chylomicron apoproteins (apoB, apoA-I) and utilized for indirect immunofluorescent localization of these apoproteins within rat intestinal epithelium during normal and impaired lipid absorption.
R M Glickman, A Kilgore, J Khorana
doaj   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source

Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease

Journal of Lipid Research, 2021
Chylomicron retention disease (CRD) is an autosomal recessive disorder associated with biallelic Sar1b mutations leading to defects in intracellular chylomicron (CM) trafficking and secretion.
Nickolas Auclair, Alain T. Sané, Lena Ahmarani, Nathalie Patey, Jean-François Beaulieu, Noel Peretti, Schohraya Spahis, Emile Levy   +7 more
doaj   +1 more source

Whole Wheat Flour Components Intervention Against Lead Toxicity: Impacts on Metal Bioavailability and Protection of the Intestinal Epithelial Barrier

Food Frontiers, Volume 7, Issue 5, September 2026.
ABSTRACT Consumption of whole wheat flour promotes lead excretion, yet the functional components reducing lead bioavailability and their protective mechanisms remain unclear. To identify these components and to validate whether their mechanism is related to protection of the intestinal barrier, this study established an in vitro model combining ...
Zhiyin Xiao, Tianhang Huang, Fengjiao Fan, Jian Ding, Xiaoyi Jiang, Xinyang Sun, Peng Li, Yong Fang   +7 more
wiley   +1 more source

High-fat diet reveals the impact of Sar1b defects on lipid and lipoprotein profile and cholesterol metabolism

Journal of Lipid Research, 2023
Biallelic pathogenic variants of the Sar1b gene cause chylomicron retention disease (CRD) whose central phenotype is the inability to secrete chylomicrons.
Nickolas Auclair, Alain T. Sané, Léna Ahmarani, Nour-El-Houda Ould-Chikh, Nathalie Patey, Jean-François Beaulieu, Edgard Delvin, Schohraya Spahis, Emile Levy   +8 more
doaj   +1 more source