Results 31 to 40 of about 19,423 (204)

A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) results in altered postprandial chylomicron triglyceride and retinyl palmitate response in normolipidemic carriers.

Journal of Lipid Research, 1996
An Asn291Ser mutation in exon 6 of the lipoprotein lipase gene (LPL) frequently occurs in Caucasians (2-4%) and results in a partial catalytic defect.
S N Pimstone, S M Clee, S E Gagné, L Miao, H Zhang, E A Stein, M R Hayden   +6 more
doaj   +1 more source

Role of the Gut in Diabetic Dyslipidemia

Frontiers in Endocrinology, 2020
Type 2 diabetes (T2D) is associated with increased risk of cardiovascular disease (CVD). In insulin resistant states such as the metabolic syndrome, overproduction and impaired clearance of liver-derived very-low-density lipoproteins and gut-derived ...
Priska Stahel, Changting Xiao, Avital Nahmias, Gary F. Lewis   +3 more
doaj   +1 more source

Protein Kinase D2 drives chylomicron‐mediated lipid transport in the intestine and promotes obesity

EMBO Molecular Medicine, 2021
Lipids are the most energy‐dense components of the diet, and their overconsumption promotes obesity and diabetes. Dietary fat content has been linked to the lipid processing activity by the intestine and its overall capacity to absorb triglycerides (TG).
Jonathan Trujillo‐Viera, Rabih El‐Merahbi, Vanessa Schmidt, Till Karwen, Angel Loza‐Valdes, Akim Strohmeyer, Saskia Reuter, Minhee Noh, Magdalena Wit, Izabela Hawro, Sabine Mocek, Christina Fey, Alexander E Mayer, Mona C Löffler, Ilka Wilhelmi, Marco Metzger, Eri Ishikawa, Sho Yamasaki, Monika Rau, Andreas Geier, Mohammed Hankir, Florian Seyfried, Martin Klingenspor, Grzegorz Sumara   +23 more
doaj   +1 more source

Simultaneous measurements of chylomicron lipolysis and remnant removal using a doubly labeled artificial lipid emulsion: studies in normolipidemic and hyperlipidemic subjects.

Journal of Lipid Research, 1994
An artificial chylomicron-like lipid emulsion doubly labeled with tri[(N)3H]oleoylglycerol ([3H]TO) and cholesteryl [1-14C]oleate ([14C]CO) was infused intravenously into human subjects with the purpose of simultaneously measuring the plasma ...
E R Nakandakare, S A Lottenberg, H C Oliveira, M C Bertolami, K S Vasconcelos, G Sperotto, E C Quintão   +6 more
doaj   +1 more source

Influence of chylomicron remnants on human monocyte activation in vitro. [PDF]

, 2011
Background and aimsAtherosclerosis is known to be an inflammatory disease and there is increasing evidence that chylomicron remnants (CMR), the lipoproteins which carry dietary fats in the blood, cause macrophage foam cell formation and inflammation.
De Pascale, C., Hathaway, N, Bentley, C., F. Bejta, Hathaway, N., De Pascale, C, C.P.D. Wheeler-Jones, Widdows, J, Lawson, C, Bentley, C, Botham, K M, J. Widdows, Botham, K.M., M. Avella, Bejta, F., K.M. Botham, C. De Pascale, C. Lawson, C. Bentley, N. Hathaway, Avella, M A, Wheeler-Jones, C P D, Widdows, J., Bejta, F, Lawson, C., Wheeler-Jones, C.P.D., Avella, M.   +26 more
core   +1 more source

Fatty acid esterification and chylomicron formation during fat absorption: 1. Triglycerides and cholesterol esters

Journal of Lipid Research, 1963
Experiments were conducted to study in vivo the over-all fatty acid specificity of the mechanisms involved in chylomicron cholesterol ester and triglyceride formation during fat absorption in the rat. Mixtures containing similar amounts of two, three, or
Arthur Karmen, Malcolm Whyte, DeWitt S. Goodman   +2 more
doaj   +1 more source

Multiple processes are involved in the uptake of chylomicron remnants by mouse peritoneal macrophages

Journal of Lipid Research, 1998
The processes responsible for the uptake of chylomicron remnants by macrophages were investigated using freshly isolated cells from low density lipoprotein (LDL) receptor, very low density lipoprotein (VLDL) receptor and apolipoprotein E knockout mice ...
Yoshio Fujioka, Allen D. Cooper, Loren G. Fong   +2 more
doaj   +1 more source

Role of lymph flow in intestinal chylomicron transport

, 1985
In this study we investigated the influence of lymph flow on chylomicron transport. We examined the effects of varying the hydration of the interstitial matrix on chylomicron appearance time and on lymphatic lipid transport rate when a lipid test meal ...
P. Tso, V. Pitts, D. N. Granger
core   +1 more source

Kinetics of chylomicron triglyceride removal from plasma in rats: a comparison of the anesthetized and the unanesthetized states

Journal of Lipid Research, 1970
The kinetics of chylomicron-TG removal were studied using an experimental method which allows measurements to be made under optimal physiological conditions.
K.L. Harris, J.M. Felts
doaj   +1 more source

Causes and Consequences of Hypertriglyceridemia

Frontiers in Endocrinology, 2020
Elevations in plasma triglyceride are the result of overproduction and impaired clearance of triglyceride-rich lipoproteins—very low-density lipoproteins (VLDL) and chylomicrons. Hypertriglyceridemia is characterized by an accumulation in the circulation
Chris J. Packard, Jan Boren, Marja-Riitta Taskinen   +2 more
doaj   +1 more source