Results 11 to 20 of about 21,613 (212)

Dietary fat induced chylomicron-mediated LPS translocation in a bicameral Caco-2cell model

Lipids in Health and Disease, 2023
Background There is increasing evidence that dietary fat, especially saturated fat, promotes the translocation of lipopolysaccharide (LPS) via chylomicron production in the gut.
Monic M. M. Tomassen, Coen Govers, A. Paul Vos, Nicole J. W. de Wit   +3 more
doaj   +2 more sources

The intracellular chylomicron highway: novel insights into chylomicron biosynthesis, trafficking, and secretion [PDF]

Current Opinion in Lipidology
Purpose of review Chylomicron biosynthesis plays a vital role in supplying essential lipids and lipid soluble vitamins to peripheral tissues for various functions. Despite this, the intracellular synthesis, trafficking, and secretion of chylomicrons remains only partly understood.
Visser, Ankia, Hussain, M. Mahmood, Kuivenhoven, Jan Albert   +2 more
openaire   +3 more sources

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

N-3 fatty acids and chylomicron metabolism in the rat

Journal of Lipid Research, 1997
Dietary n-3 fatty acids (FAs) reduce postprandial triacylglycerol concentrations in humans by unknown mechanisms. Our goals were to reproduce this phenomenon in the rat, and then to determine the mechanism.
W S Harris, B E Hustvedt, E Hagen, M H Green, G Lu, C A Drevon   +5 more
doaj   +1 more source

Chylomicrons promote intestinal absorption of lipopolysaccharides

Journal of Lipid Research, 2009
Recent data suggest that dietary fat promotes intestinal absorption of lipopolysaccharides (LPS) from the gut microflora, which might contribute to various inflammatory disorders.
Sarbani Ghoshal, Jassir Witta, Jian Zhong, Willem de Villiers, Erik Eckhardt   +4 more
doaj   +1 more source

Hepatic lipase treatment of chylomicron remnants increases exposure of apolipoprotein E.

Journal of Lipid Research, 1993
The consequences of hepatic lipase treatment of chylomicron remnants were studied. Rats were fed corn oil to induce production and secretion of chylomicrons and were then injected with polyclonal antiserum raised against hepatic lipase to specifically ...
DL Brasaemle, K Cornely-Moss, A Bensadoun   +2 more
doaj   +1 more source

Differences in the processing of chylomicron remnants and beta-VLDL by macrophages.

Journal of Lipid Research, 1990
To gain a detailed understanding of those factors that govern the processing of dietary-derived lipoprotein remnants by macrophages we examined the uptake and degradation of rat triacylglycerol-rich chylomicron remnants and rat cholesterol-rich beta-very
JL Ellsworth, LG Fong, FB Kraemer, AD Cooper   +3 more
doaj   +1 more source

Transfer of human lymph chylomicron constituents to other lipoprotein density fractions during in vitro lipolysis

Journal of Lipid Research, 1982
To ascertain whether chylomicron constituents would be transferred to low density lipoprotein (LDL, d 1.019-1.063 g/ml) and high density lipoprotein (HDL, d 1.063-1.21 g/ml) density fractions during lipolysis in the absence of other lipoproteins, the in ...
E J Schaefer, M G Wetzel, G Bengtsson, R O Scow, H B Brewer, Jr, T Olivecrona   +5 more
doaj   +1 more source

Intestinal basolateral lipid substrate transport is linked to chylomicron secretion and is regulated by apoC-III

Journal of Lipid Research, 2019
Chylomicron metabolism is critical for determining plasma levels of triacylglycerols (TAGs) and cholesterol, both of which are risk factors for CVD.
Diana Li, Cayla N. Rodia, Zania K. Johnson, Minkyung Bae, Angelika Muter, Amy E. Heussinger, Nicholas Tambini, Austin M. Longo, Hongli Dong, Ji-Young Lee, Alison B. Kohan   +10 more
doaj   +1 more source

Removal of chylomicron remnants in transgenic mice overexpressing normal and membrane-anchored hepatic lipase

Journal of Lipid Research, 2005
The LDL receptor and the LDL receptor-related protein (LRP) mediate the removal of chylomicron remnants. The LRP pathway involves sequestration of particles in the space of Disse.
Sung-Joon Lee, Sujata Kadambi, Kenneth C-W. Yu, Christopher David, Salman Azhar, Allen D. Cooper, Sungshin Y. Choi   +6 more
doaj   +1 more source