Results 1 to 10 of about 1,859,933 (297)

Identification of Novel Inhibitors of Dietary Lipid Absorption Using Zebrafish [PDF]

PLoS ONE, 2010
Pharmacological inhibition of dietary lipid absorption induces favorable changes in serum lipoprotein levels in patients that are at risk for cardiovascular disease and is considered an adjuvant or alternative treatment with HMG-CoA reductase inhibitors (
Donna Huryn, Justin D Clifton, Amos Smith   +2 more
exaly   +4 more sources

Mechanical Regulation of Lipid and Sugar Absorption by Piezo1 in Enterocytes

Acta Pharmaceutica Sinica B
Obesity is primarily caused by excessive intake as well as absorption of sugar and lipid. Postprandial surge in distention pressure and intestinal motility accelerates the absorption of nutrients. The response of intestinal epithelial cells to mechanical
Shiqi Jia, Tian Tao, Wenying Guo
exaly   +4 more sources

FXR Activation Protects Against NAFLD via Bile-Acid-Dependent Reductions in Lipid Absorption [PDF]

Cell Metabolism, 2021
FXR agonists are used to treat non-alcoholic fatty liver disease (NAFLD), in part because they reduce hepatic lipids. Here, we show that FXR activation with the FXR agonist GSK2324 controls hepatic lipids via reduced absorption and selective decreases in
Anders Thorell, Hanns-Ulrich Marschall, William D Barshop   +2 more
exaly   +4 more sources

Amentoflavone-Enriched Selaginella rossii Warb. Suppresses Body Weight and Hyperglycemia by Inhibiting Intestinal Lipid Absorption in Mice Fed a High-Fat Diet. [PDF]

Life (Basel), 2022
Many Selaginellaceae species are used as traditional medicines in Asia. This study is the first to investigate the anti-obesity and anti-diabetic effects of Selaginella rossii (SR) in high-fat diet (HFD)–fed C57BL/6J mice.
Lee H, Cho S, Kim SY, Ju J, Lee SW, Choi S, Li H, Piao R, Park HY, Jeong TS.   +9 more
europepmc   +2 more sources

<i>B. vulgatus</i> ameliorates high-fat diet-induced obesity through modulating intestinal serotonin synthesis and lipid absorption in mice. [PDF]

Gut Microbes
The consumption of high-fat diets (HFD) and an imbalance in gut microbiome are linked to obesity. However, the intricate connection between them and the underlying mechanisms involved in lipid digestion and absorption remain largely unclear.
Wen X, Feng X, Xin F, An R, Huang H, Mao L, Liu P, Zhang J, Huang H, Liu X, Wang W.   +10 more
europepmc   +2 more sources

Fatty acid nitroalkenes regulate intestinal lipid absorption. [PDF]

J Lipid Res
Fatty acid nitroalkenes (NO2-FA) are tissue-protective and anti-inflammatory endogenous lipid mediators. A unique electrophilic character promotes reversible reactions with protein thiols, influencing key cellular functions. Given their generation during
Schopfer FJ, Teng L, Sekandari A, Ekhator ES, Kohan AB, Freeman BA, Fazzari M.   +6 more
europepmc   +2 more sources

Adipocyte Iron Levels Impinge on a Fat-Gut Crosstalk to Regulate Intestinal Lipid Absorption and Mediate Protection From Obesity [PDF]

Cell Metabolism, 2021
Ruth Gordillo, Leon Straub, Zhuzhen Zhang   +2 more
exaly   +2 more sources

Extracellular Vesicle-Encapsulated Small RNAs From Clostridium Butyricum Modulate Host Intestinal Lipid Metabolism. [PDF]

J Extracell Vesicles
The gut microbiota plays a critical role in regulating intestinal lipid metabolism, yet the mechanisms governing microbiota–host interactions during lipid uptake remain unclear.
Hu H, He Y, Liang J, Han Q, Liang X, Cao G, Tang Y, He L, Yin Y, Zhou X.   +9 more
europepmc   +2 more sources

Sulfosuccinimidyl oleate ameliorates the high-fat diet-induced obesity syndrome by reducing intestinal and hepatic absorption

Frontiers in Pharmacology, 2023
Background: A high-fat Western diet is a risk factor for obesity and steatosis. Reducing intestinal absorption of a high-fat diet (HFD) is a feasible strategy to control obesity.
Qiming Ma, Li Wen, Yanxia Tian, Liqin Ma, Zhangsheng Wen, Yang Kun, Mengping Xu, Xiaoping Liu   +7 more
doaj   +1 more source

Inhibition of chylomicron assembly leads to dissociation of hepatic steatosis from inflammation and fibrosis

Journal of Lipid Research, 2021
Regulating dietary fat absorption may impact progression of nonalcoholic fatty liver disease (NAFLD). Here, we asked if inducible inhibition of chylomicron assembly, as observed in intestine-specific microsomal triglyceride (TG) transfer protein knockout
Yan Xie, Elizabeth P. Newberry, Elizabeth M. Brunt, Samuel J. Ballentine, Saeed Soleymanjahi, Elizabeth A. Molitor, Nicholas O. Davidson   +6 more
doaj   +1 more source