Results 21 to 30 of about 233,256 (256)

Sulfosuccinimidyl oleate ameliorates the high-fat diet-induced obesity syndrome by reducing intestinal and hepatic absorption

Frontiers in Pharmacology, 2023
Background: A high-fat Western diet is a risk factor for obesity and steatosis. Reducing intestinal absorption of a high-fat diet (HFD) is a feasible strategy to control obesity.
Qiming Ma, Li Wen, Yanxia Tian, Liqin Ma, Zhangsheng Wen, Yang Kun, Mengping Xu, Xiaoping Liu   +7 more
doaj   +1 more source

Lipid absorption and metabolism. [PDF]

Environmental Health Perspectives, 1979
Metabolic processes occurring within the mucosal cell are critical in determining results of interactions between environmental agents and the alimentary tract. The absorption, metabolism, and transport of lipids affects most those agents which are lipid soluble.
A, Kuksis, N A, Shaikh, A G, Hoffman
openaire   +2 more sources

Inhibition of chylomicron assembly leads to dissociation of hepatic steatosis from inflammation and fibrosis

Journal of Lipid Research, 2021
Regulating dietary fat absorption may impact progression of nonalcoholic fatty liver disease (NAFLD). Here, we asked if inducible inhibition of chylomicron assembly, as observed in intestine-specific microsomal triglyceride (TG) transfer protein knockout
Yan Xie, Elizabeth P. Newberry, Elizabeth M. Brunt, Samuel J. Ballentine, Saeed Soleymanjahi, Elizabeth A. Molitor, Nicholas O. Davidson   +6 more
doaj   +1 more source

An Updated Perspective on the Dual-Track Model of Enterocyte Fat Metabolism

Journal of Lipid Research, 2022
The small intestinal epithelium has classically been envisioned as a conduit for nutrient absorption, but appreciation is growing for a larger and more dynamic role for enterocytes in lipid metabolism.
Joshua R. Cook, Alison B. Kohan, Rebecca A. Haeusler   +2 more
doaj   +1 more source

Absorption of cholesterol by the gallbladder

Journal of Lipid Research, 1976
To study whether cholesterol is absorbed by the gallbladder, we instilled from 1 to 300 nmoles of [4-14C]cholesterol dissolved in 1 ml of guinea pig bile into the in situ guinea pig gallbladder.
D H Neiderhiser, C K Harmon, H P Roth
doaj   +1 more source

Cideb facilitates the lipidation of chylomicrons in the small intestine

Journal of Lipid Research, 2014
Cell death-inducing DFF45-like effector b (Cideb), an endoplasmic reticulum (ER)- and lipid droplet (LD)-associated protein, has been shown to play a critical role in maintaining hepatic lipid homeostasis by promoting the lipidation and maturation of ...
Li-Jun Zhang, Chao Wang, Yuan Yuan, Hui Wang, Jie Wu, Fang Liu, Le Li, Xing Gao, Yuan-Lin Zhao, Pei-Zhen Hu, Peng Li, Jing Ye   +11 more
doaj   +1 more source

apoA-IV tagged with the ER retention signal KDEL perturbs the intracellular trafficking and secretion of apoB

Journal of Lipid Research, 2004
To examine the role of apolipoprotein A-IV (apoA-IV) in the intracellular trafficking and secretion of apoB, COS cells were cotransfected with microsomal triglyceride transfer protein (MTP), apoB-41 (amino terminal 41% of apoB), and either native apoA-IV
James W. Gallagher, Richard B. Weinberg, Gregory S. Shelness   +2 more
doaj   +1 more source

From Congenital Disorders of Fat Malabsorption to Understanding Intra-Enterocyte Mechanisms Behind Chylomicron Assembly and Secretion

Frontiers in Physiology, 2021
During the last two decades, a large body of information on the events responsible for intestinal fat digestion and absorption has been accumulated. In particular, many groups have extensively focused on the absorptive phase in order to highlight the ...
Emile Levy, Emile Levy, Emile Levy, Jean François Beaulieu, Schohraya Spahis, Schohraya Spahis   +5 more
doaj   +1 more source

Determination of unidirectional uptake rates for lipids across the intestinal brush border

Journal of Lipid Research, 1972
An in vitro method is presented which measures valid, unidirectional uptake rates for lipids across the intestinal brush border. This method combines analysis by a newly devised, double isotope counting system for solubilized tissue with the use of a ...
Verney L. Sallee, Frederick A. Wilson, John M. Dietschy   +2 more
doaj   +1 more source

Intestinal lipid absorption

American Journal of Physiology-Endocrinology and Metabolism, 2009
Our knowledge of the uptake and transport of dietary fat and fat-soluble vitamins has advanced considerably. Researchers have identified several new mechanisms by which lipids are taken up by enterocytes and packaged as chylomicrons for export into the lymphatic system or clarified the actions of mechanisms previously known to participate in these ...
Jahangir, Iqbal, M Mahmood, Hussain
openaire   +3 more sources