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Chylomicron and chylomicron remnant catabolism

Current Opinion in Lipidology, 1991
Hepatic clearance of chylomicrons and chylomicron remnants appears to involve several steps: sequestration in the space of Disse, further lipolytic processing, and receptor-mediated internalization and degradation. The low-density lipoprotein receptor and possibly the low-density lipoprotein receptor-related protein may participate in this process ...
Robert W. Mahley, M. Mahmood Hussain
openaire   +2 more sources

Effects of VLDL, chylomicrons, and chylomicron remnants on platelet aggregability

Thrombosis Research, 1995
Although influences of cholesterol-rich lipoproteins on platelet aggregation are well established, the knowledge of interactions between triglyceride-rich lipoproteins and platelets, in particular in the postprandial state, is limited and controversial.
Orth, Matthias   +2 more
openaire   +4 more sources

Characterization of human chylomicrons

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982
Apolipoprotein and lipid composition of differently sized chylomicrons from healthy volunteers was determined. During their intravasal catabolism the chylomicrons lose triacylglycerol and apolipoproteins. Decreasing particle size results in a loss of apolipoprotein C and apolipoprotein E peptides and an increase in apolipoproteins B and A-I, which ...
A. Poli, Augustin J, Haberbosch W
openaire   +3 more sources

Enhanced lymphatic transport of bioactive lipids: cell culture study of polymethoxyflavone incorporation into chylomicrons.

Food & Function, 2013
Polymethoxyflavones (PMFs) are bioactive flavonoids found in citrus fruits that have been shown to have potential health promoting properties. However, their application as nutraceuticals in functional foods and beverages is currently limited due to ...
Mingfei Yao   +5 more
semanticscholar   +1 more source

The quantitative separation of chylomicrons and chylomicron remnants by column chromatography

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
Chylomicrons and chylomicron remnants cannot be separated by classical techniques of ultracentrifugation or gel filtration, since there is a marked overlap of density and size. Chylomicron remnants develop a high negative surface charge during their formation presumably due to surface-oriented free fatty acids.
James M. Felts, James M. Felts
openaire   +3 more sources

Chylomicrons and chylomicron remnants in coronary artery disease: a case-control study

Atherosclerosis, 1987
Epidemiologic studies of coronary artery disease have largely overlooked the role of triglyceride-rich lipoproteins circulating in the post-prandial state. We have conducted a case-control study in males which examined fasting plasma lipoproteins and lipoproteins circulating 4 h after ingestion of a test meal containing fat and cholesterol.
John J. Morgan   +21 more
openaire   +3 more sources

Signposts in the assembly of chylomicrons

Frontiers in Bioscience, 2001
Intestinal cells synthesize and secrete chylomicrons in the postprandial state. Synthesis of these particles is defective in abetalipoproteinemia and chylomicron retention disease. Chylomicrons are very large, heterogeneous, lipid-rich particles ranging in diameters from 75 to 450 nm and function to transport dietary fat and fat-soluble vitamins to ...
M. Mahmood Hussain   +4 more
openaire   +3 more sources

Conversion of chylomicrons into remnants

Atherosclerosis, 1998
The turnover of chylomicrons in the blood is the sum of several processes. The native chylomicron is synthesized in the intestine out of available substrates. When the chylomicron enters the circulation exchanges of apolipoproteins with other lipoproteins, it also binds to the vascular endothelium where the chylomicron is lipolyzed by lipoprotein ...
Thomas Olivecrona, Magnus Hultin
openaire   +3 more sources

Chylomicron metabolism

Biochemical Society Transactions, 2004
Chylomicrons are the ‘orphans’ of the lipoprotein family. Difficulty of measurement has impeded understanding of their metabolism. Plasma concentrations of chylomicrons and chylomicron remnants give no insight into the magnitude of substrate flux through these pathways.
openaire   +2 more sources

Lycopene and Chylomicrons

2009
Lycopene, like other lipophilic dietary components, is absorbed from the intestine in chylomicrons. These large, triacylglycerol-rich lipoproteins are metabolized in the blood by removal of some of the triacylglycerol, leaving smaller chylomicron remnants particles that deliver the remaining lipids to the liver.
Kathleen M. Botham, Elena Bravo
openaire   +2 more sources

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