Results 21 to 30 of about 224,064 (235)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
La importància de l'anàlisi històrica de les imatges de la ciència, amb Nick Hopwood [PDF]
, 2011 La Història de la Ciència ha mostrat una tendència tradicional a l'estudi dels textos oblidant-se de les imatges. Però la pràctica científica produeix una àmplia varietat de representacions visuals i el seu estudi ofereix una excel·lent base per ...
Florensa, Clara, Hopwood, Nick
core +1 more source
UO2 surface oxidation by mixtures of water vapor and hydrogen as a function of temperature [PDF]
, 2015 In the present work, X-Ray Photoelectron Spectroscopy (XPS) was used to study the effect of water vapor on the UO2 surface as a function of temperature. The experiments were performed in situ inside a high pressure chamber attached to the XPS instrument.
Casas Pons, Ignasi +5 more
core +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
From night bustle to printed quietness [PDF]
, 2001 Des del punt de vista d'un científic, la comunicació científica entre col·legues significa la possibilitat de reconeixement dels postulats que es desprenen de la seva recerca, és la ciència de dia, la quietud de la ciència impresa.
Jacob, François
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
La ficció com a eina docent en l’àmbit de les ciències i la tecnologia [PDF]
, 2012 La motivació de l’alumnat és la fita a aconseguir avui en dia, en un món cada cop més canviant sobretot propiciat pels avenços tecnològics i científics. Per tal de despertar l´interès per aquestes matèries incloses en el pla d’estudi actual dintre de l´
Martín Gallardo, Rubén
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Thomas Sturm, Research Scholar al Max Planck Institute for the History of Science [PDF]
, 2008 Format com a filòsof, però amb un fort interès per la història de la ciència, Thomas Sturm és un especialista en filosofia moderna i les relacions entre la història i la filosofia de la ciència.
Mata M., Virginia, Sturm, Thomas
core +1 more source