Results 31 to 40 of about 6,288 (254)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Dissection of a Redox Relay: H2O2-Dependent Activation of the Transcription Factor Pap1 through the Peroxidatic Tpx1-Thioredoxin Cycle

Cell Reports, 2013
In fission yeast, the transcription factor Pap1 undergoes H2O2-dependent oxidation that promotes its nuclear accumulation and the activation of an antioxidant gene program.
Isabel A. Calvo, Susanna Boronat, Alba Domènech, Sarela García-Santamarina, José Ayté, Elena Hidalgo   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

EduWikiLab : la creació d'un espai col·laboratiu sobre treballs pràctics al laboratori i al taller [PDF]

, 2012
La realització de treballs pràctics (al laboratori i el taller) té un gran potencial educatiu per a les matèries de ciències experimentals i aplicades.
Besson, Isabel, Domènech Casal, Jordi, Goytia, Elisa, Sánchez, Núria   +3 more
core   +2 more sources

Duplex Stainless Steel Laser‐Surface Textured: Stability in Brine Solution

Advanced Engineering Materials, EarlyView.
Controlled laser‐surface treatment (LST) of duplex DSS2205 steel is performed to increase its stability in brine solution under cyclic electrochemical assays. The superior protection with respect to flat and smooth panels is attributed to the presence of FeCr2O4 as the main protective oxide layer in the LST surface, after corrosion tests. The stability
Mohammad Rezayat, Hamidreza Enshaei, Elaine Armelin, José I. Iribarren, Antonio Mateo, Miguel Morales   +5 more
wiley   +1 more source

Aprendre a justificar científicament a partir de l'estudi de l'origen dels éssers vius

Enseñanza de las Ciencias, 2015
Aquest treball presenta una recerca en relació a l'aprenentatge de les ciències a partir de l'escriptura de textos justificatius sobre l'origen dels éssers vius amb alumnes de 14 anys.
Enric Custodio Fitó, Conxita Márquez, Neus Sanmartí   +2 more
doaj   +1 more source

Dual‐Mode Film Based on Highly Scattering Nanofibers and Upcycled Chips‐Bags for Year‐Round Thermal Management

Advanced Functional Materials, EarlyView.
Intelligent radiative cooling devices, adaptable to various weather conditions, have the potential for year‐round energy savings. This study introduces a sustainable dual‐mode film made from polycaprolactone nanofibers and upcycled chip bags for effective thermal management.
Qimeng Song, Stefan Rettinger, Chengzhang Xu, Ulrich Mansfeld, Markus Retsch   +4 more
wiley   +1 more source

Construint la visió sistèmica del cos humà a partir de la lectura crítica d’una controvèrsia socio-científica

Ciències, 2013
En aquest article es mostra el desenvolupament d’una activitat, realitzada a 3r d’ESO i 1r de batxillerat per treballar la visió sistèmica del cos humà a través de la lectura crítica de la entrevista d’un farmacèutic publicada a un diari. L’activitat vol
Ana Maria Domènech, Conxita Màrquez
doaj   +1 more source

All‐in‐One Analog AI Hardware: On‐Chip Training and Inference with Conductive‐Metal‐Oxide/HfOx ReRAM Devices

Advanced Functional Materials, EarlyView.
An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone, Victoria Clerico, Wooseok Choi, Tommaso Stecconi, Folkert Horst, Laura Bégon‐Lours, Matteo Galetta, Antonio La Porta, Nikhil Garg, Fabien Alibart, Bert Jan Offrein, Valeria Bragaglia   +11 more
wiley   +1 more source

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts

Nature Communications, 2018
During S phase of the cell cycle, transcription and replication need to be coordinated in order to avoid conflicts leading to potential genomic instability.
Alba Duch, Berta Canal, Sonia I. Barroso, María García-Rubio, Gerhard Seisenbacher, Andrés Aguilera, Eulàlia de Nadal, Francesc Posas   +7 more
doaj   +1 more source