Results 11 to 20 of about 228,992 (183)

HORKHEIMER: UMA CRÍTICA AO CIENTIFICISMO E AO LIBERALISMO DEWEYANO

Revista Binacional Brasil - Argentina, 2017
Este artigo tem o objetivo de apresentar as principais ideias de Dewey sobre o método científico pragmático e a sua teoria de democracia e sociedade, assim como expor analiticamente os seus enfrentamentos críticos, recorrendo,
Wilson da Silva Santos
doaj   +1 more source

Papel da oximetria nocturna no rastreio da síndroma de apneia-hipopneia obstrutiva do sono**Estudo efectuado no âmbito de um mestrado em Patologia Respiratória da Faculdade de Ciências Médicas de Lisboa. / Study undertaken as part of an MSc in Respiratory Pathology, Lisbon University School of Medical Sciences.

Revista Portuguesa de Pneumologia, 2007
AbstractAim: The aim of our study was to evaluate the sensitivity and specificity of Nocturnal Oximetry (NO) as a diagnostic screening tool for obstructive sleep apnoea hypopnoea syndrome (OSAHS), compared with polysomnography (PSG) as the gold standard.Methodology: 63 patients with clinical suspicion of OSAHS and exclusion of respiratory disease under-
Celestina Ventura, Ana Sofia Oliveira, Rita Dias, Joana Teixeira, Cristina Canhão, Odete Santos, Paula Pinto, Cristina Bárbara   +7 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

ASSOCIATE EDITORS AND REVIEWERS AD HOC

Ciência Florestal, 2013
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Ciência Florestal
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Helena Antipoff: ciência, compromisso social e solidariedade sem fronteiras

Revista Cocar, 2018
Este artigo tem o objetivo de revisitar as contribuições de Helena Antipoff (1892-1974) para a Educação brasileira. No final dos anos 20, Antipoff chegou ao Brasil contribuindo com conhecimento trazido de grandes centros de pesquisa na época, como França, Suíça e da sua experiência na sua terra natal, a União Soviética.
França, Ana Raquel de Oliveira, Gonçalves, Luiz Gonzaga   +1 more
openaire   +1 more source