Results 21 to 30 of about 228,992 (183)

Uma pedagogia da escrita: intelectuais lusobrasileiros no século XVIII

open access: yesMatraga, 2011
A atuação intelectual, dentro dos quadros da ilustração luso-brasileira, implicou a adesão inconteste ao princípio da utilidade. A clara tendência ao pragmatismo, por sua vez, atrelou-se ao compromisso com o progresso e a pátria.
Claudete Daflon
doaj  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Anais I Encontro Científico do Programa de Pós-Graduação em Ciências em Saúde – UFMT/Sinop: Resumos Simples

open access: yesScientific Electronic Archives, 2019
Nesse link estão publicados os Anais I Encontro Científico do Programa de Pós-Graduação em Ciências em Saúde – UFMT/Sinop: Resumos ...
openaire   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

CULTURA POP E CIÊNCIA: O POTENCIAL DO MANGÁ DEMON SLAYER PARA A DIVULGAÇÃO CIENTÍFICA

open access: yesBrazilian Creative Industries Journal
Esta pesquisa aproxima noções sobre a divulgação científica por meio da ficção literária, com foco no formato do mangá japonês. Busca-se aqui apontar o potencial narrativo da série Demon Slayer como instrumento de divulgação científica, bem como ...
Leonardo José Costa   +1 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

EDITORES ASSOCIADOS E REVISORES AD HOC

open access: yesCiência Florestal, 2014
-
Ciência Florestal
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

open access: yesFEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla   +10 more
wiley   +1 more source

DELIMITANDO O CAMPO DA PSICOLOGIA DA CIÊNCIA: UMA REVISÃO DE LITERATURA

open access: yesPsicologia em Estudo
Esta pesquisa teve por objetivo delimitar os objetos, objetivos, estratégias metodológicas e potenciais aplicações da psicologia da ciência. Para tanto, foi realizada uma revisão sistemática da literatura, na base de dados Portal de Periódicos da CAPES.
Carolina Laurenti, Taisa Scarpin Guazi
doaj   +1 more source

Home - About - Disclaimer - Privacy