Results 11 to 20 of about 27,201 (172)

New ligands of the Cellular Retinoic Acid-Binding Protein 2 (CRABP2) suggest a role for this protein in chromatin remodeling

Revista de Ciências Farmacêuticas Básica e Aplicada, 2014
Retinoic acid (RA) regulates the transcription of a series of genes involved in cell proliferation, differentiation and apoptosis by binding to the RA Receptor (RAR) and Retinoid X Receptor (RXR) heterodimers.
Daniella de Barros Rossetto, Eric Nishimura Kiyomoto, Carlos Eduardo Brantis de Carvalho, Cleslei Fernando Zanelli, Sandro Roberto Valentini   +4 more
doaj   +1 more source

Psoralen and Bergapten: In Silico Metabolism and Toxicophoric Analysis of Drugs Used to Treat Vitiligo

Journal of Pharmacy & Pharmaceutical Sciences, 2009
PURPOSE: to discuss the contribution of psoralen and bergapten metabolites on psoralens toxicity. METHODS: Computational chemistry prediction of metabolic reactions and toxicophoric groups based on the expert systems Derek and Meteor. RESULTS: a total of
Vinicius Barreto da Silva, Daniel Fábio Kawano, Ivone Carvalho, Edemilson Cardoso Conceição, Osvaldo Freitas, Carlos Henrique Tomich de Paula Silva   +5 more
doaj   +1 more source

Dinâmica molecular: teoria e aplicações em planejamento de fármacos

Eclética Química, 2018
Molecular dynamics (MD) is a powerful computational tool used for rational drug design in medicinal chemistry. MD is an extension of Molecular Mechanics, where the dynamic behavior of a molecular system is simulated through numerical integration of the ...
Adriana Mieco Namba, Vinícius Barreto da Silva, Carlos Henrique Tomich de Paula da Silva   +2 more
doaj   +1 more source

X Congresso Iberoamericano de Ciências Farmacêuticas - Programa

, 2023
X Congresso Iberoamericano de Ciências Farmacêuticas ...
Ramos, Fernando
core  

Adequação da prescrição de medicamentos na Atenção Primária à Saúde de Ribeirão Preto-SP: estudo transversal

Revista Brasileira de Medicina de Família e Comunidade, 2018
Objetivo: Este estudo transversal visa analisar comparativamente as prescrições de medicamentos provenientes da atenção básica tradicional (Unidades Básicas de Saúde - UBS) com as da Estratégia de Saúde da Família (ESF).
Maria Olívia Barboza Zanetti, Juliana Maldonado Marchetti, Regina Célia Garcia de Andrade   +2 more
doaj   +1 more source

Human Leukocyte Elastase Triggered Nanoparticles for Targeted Antimicrobial Delivery and Oral Microbial Modulation

Advanced NanoBiomed Research, EarlyView.
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis, Ignacio Insua, Farah N. S. Raja, Álvaro Vila, William M. Palin, Michael R. Milward, Paul R. Cooper, Sarah A. Kuehne, Owen Addison, Paco Fernandez‐Trillo   +9 more
wiley   +1 more source

Application of dynamic modelling and model‐based predictive control to enhance a cooling tower

The Canadian Journal of Chemical Engineering, EarlyView.
Model predictive control (MPC) applied to improve the operation of cooling towers. Abstract Model predictive control (MPC) differs from traditional feedback control by making predictions within a time horizon, providing better control actions for the process.
Douglas de Almeida Giardini, Adriana Guglielmi Ranieri Miranda, Wilson Hideki Hirota, Bruno Faccini Santoro, José Ermirio Ferreira de Moraes   +4 more
wiley   +1 more source

The potential of phenothiazinium dyes as cytotoxicity markers in cisplatin-treated cells

Scientific Reports, 2023
Assessing the in vitro toxicity of compounds on cell cultures is an important step during the screening of candidate molecules for diverse applications. Among the strategies employed to determine cytotoxicity, MTT, neutral red, and resazurin are commonly
Luiz Miguel Pereira, Gisele Bulhões Portapilla, Guilherme Thomaz Pereira Brancini, Bruna Possato, Cássia Mariana Bronzon da Costa, Péricles Gama Abreu-Filho, Mark Wainwright, Ana Patrícia Yatsuda, Gilberto Úbida Leite Braga   +8 more
doaj   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

IMPACTO DA IMPLANTAÇÃO DO AGENDAMENTO DAS DOAÇÕES DE SANGUE EM PERÍODO DE EPIDEMIA DE COVID NOS INDICADORES DE QUALIDADE DO HEMONÚCLEO REGIONAL DE ARARAQUARA

Hematology, Transfusion and Cell Therapy, 2021
Introdução: O Hemonúcleo Regional de Araraquara está situado na região central do estado de São Paulo e atende à regional de saúde DRS III com uma população de quase 1 milhão de habitantes.
M Kitamura, GF Rigolin, JH Simonaio, SRP Vincenzo, MCA Carvalho, RC Ribeiro, FG Cardoso, IL Brunetti   +7 more
doaj   +1 more source