Results 11 to 20 of about 10,442 (118)
Journal of Pharmacy & Pharmaceutical Sciences, 2009 PURPOSE: to discuss the contribution of psoralen and bergapten metabolites on psoralens toxicity. METHODS: Computational chemistry prediction of metabolic reactions and toxicophoric groups based on the expert systems Derek and Meteor. RESULTS: a total of
Vinicius Barreto da Silva +5 more
doaj +1 more source
Dinâmica molecular: teoria e aplicações em planejamento de fármacos
Eclética Química, 2018 Molecular dynamics (MD) is a powerful computational tool used for rational drug design in medicinal chemistry. MD is an extension of Molecular Mechanics, where the dynamic behavior of a molecular system is simulated through numerical integration of the ...
Adriana Mieco Namba +2 more
doaj +1 more source
Revista Brasileira de Medicina de Família e Comunidade, 2018 Objetivo: Este estudo transversal visa analisar comparativamente as prescrições de medicamentos provenientes da atenção básica tradicional (Unidades Básicas de Saúde - UBS) com as da Estratégia de Saúde da Família (ESF).
Maria Olívia Barboza Zanetti +2 more
doaj +1 more source
The potential of phenothiazinium dyes as cytotoxicity markers in cisplatin-treated cells
Scientific Reports, 2023 Assessing the in vitro toxicity of compounds on cell cultures is an important step during the screening of candidate molecules for diverse applications. Among the strategies employed to determine cytotoxicity, MTT, neutral red, and resazurin are commonly
Luiz Miguel Pereira +8 more
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Drug Testing and Analysis, EarlyView.Micro‐QuEChERS sample preparation coupled to LC‐QQQ‐MS enabled sensitive quantification of nitazene analogs in 100 μL of plasma. The validated method provided low detection limits and was successfully applied to an authentic intoxication case involving N‐pyrrolidino protonitazene, supporting clinical and forensic toxicology workflows.
Karla A. O. Souza +7 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos +4 more
wiley +1 more source
Hematology, Transfusion and Cell Therapy, 2021 Introdução: O Hemonúcleo Regional de Araraquara está situado na região central do estado de São Paulo e atende à regional de saúde DRS III com uma população de quase 1 milhão de habitantes.
M Kitamura +7 more
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Journal of Applied Toxicology, EarlyView.ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado +9 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Selenium (Se) is an essential micronutrient that participates in redox regulation and cellular homeostasis. Selenium‐containing ionic liquids (ILsSe) have emerged as hybrid compounds combining the properties of organoselenium molecules with the tunable features of ionic liquids.
Guilherme Schmitt Rieder +17 more
wiley +1 more source
Synthesis of New Hybrid Derivatives from Metronidazole and Eugenol Analogues as Trypanocidal Agents
Journal of Pharmacy & Pharmaceutical Sciences, 2021 Background: The search for new drug compounds is always challenging and there are several different strategies that involve the most varied and creative approaches in medicinal chemistry. One of them is the technique of molecular hybridisation: forming a
Mônica Fraccarolli Pelozo +8 more
doaj +1 more source