Results 121 to 130 of about 528,483 (278)

Ginsenoside Rb1 Targets the HRD1‐STING Axis to Mitigate Cholesterol‐Induced VSMC Senescence

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic representation of the proposed mechanism of action for Ginsenoside Rb1. Suppression of HRD1 expression in VSMCs cholesterol stimulation, leading to ER stress (BiP/XBP1s upregulation), STING pathway activation, ROS accumulation (including mitochondrial ROS), and ultimately, VSMC senescence.
Haiming Niu, Yingzhang Cai, Conghui Yu, Ning Lin, Miaolian Chen, Linli Wang   +5 more
wiley   +1 more source

MOCART 2.0 score of 60 or greater measured at 1 year post‐operatively predicts favourable clinical outcomes after surgical repair of tibiofemoral cartilage lesions

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose (1) To evaluate the relationship between the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) 2.0 score and post‐operative clinical outcomes following surgical repair of cartilage lesions in the tibiofemoral joint, and (2) to determine threshold values of the 1‐year MOCART 2.0 score associated with favourable patient ...
Hyun‐Soo Moon, Sungjun Kim, Chong‐Hyuk Choi, Min Jung, Kwangho Chung, Se‐Han Jung, Jin‐Gyu Kim, Min‐Cheol Park, Sung‐Hwan Kim   +8 more
wiley   +1 more source

Spheroid‐based matrix‐induced autologous chondrocyte implantation combined with autologous bone grafting restores physiological cartilage and subchondral bone properties in osteochondral knee defects ‐ An MRI‐based analysis

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose This study aimed to evaluate the radiological and patient‐reported outcome measures (PROMs) following spheroid‐based matrix‐induced autologous chondrocyte implantation combined with autologous bone grafting (MABCI) for the treatment of osteochondral defects of the knee.
Stephan Oehme, Benjamin Bartek, Janne Callsen, Jessica Schallock, Tobias Winkler, Thorsten Diekhoff, Tobias Jung, Danko Dan Milinkovic   +7 more
wiley   +1 more source

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

Solid State Television Camera (CID) [PDF]

The design, development and test are described of a charge injection device (CID) camera using a 244x248 element array. A number of video signal processing functions are included which maximize the output video dynamic range while retaining the ...
Green, W. T., Steele, D. W.
core   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Regulatory mechanism of cold-inducible diapause in Caenorhabditis elegans

Nature Communications
Temperature is a critical environmental cue that controls the development and lifespan of many animal species; however, mechanisms underlying low-temperature adaptation are poorly understood.
Makoto Horikawa, Masamitsu Fukuyama, Adam Antebi, Masaki Mizunuma   +3 more
doaj   +1 more source

A Perspective of Multi‐Reflecting TOF MS

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Time‐of‐flight mass spectrometry (TOF MS) excels in rapid and high‐sensitivity analysis, making it a cornerstone of analytical chemistry. But as sample complexity explodes in omics studies, so does the need for higher resolving power to ensure accurate results.
A. N. Verenchikov, V. V. Makarov, A. V. Vorobyev, S. N. Kirillov   +3 more
wiley   +1 more source

Cold EI—The Way to Improve GC‐MS and Increase Its Range of Applications

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Gas chromatography‐mass spectrometry (GC‐MS) with Cold electron ionization (EI) is based on interfacing the GC and MS with a supersonic molecular beam (SMB) along with electron ionization of vibrationally cold sample compounds in the SMB in a contact‐free fly‐through ion source (hence the name Cold EI).
Aviv Amirav, Benny Neumark, Oneg Elkabets, Alex Yakovchuk   +3 more
wiley   +1 more source

Planetary investigation utilizing an imaging spectrometer system based upon charge injection technology [PDF]

An intrinsic silicon charge injection device (CID) television sensor array has been used in conjunction with a CaMoO4 colinear tunable acousto optic filter, a 61 inch reflector, a sophisticated computer system, and a digital color TV scan converter ...
Harvey, P., Swift, R., Wattson, R. B.
core   +1 more source