Results 11 to 20 of about 923,573 (226)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Institucionalidad de innovación, ciencia y tecnología en El Salvador.

, 2013
La carpeta de propuesta de "Institucionalidad" hace un Diagnóstico de documentos como: El índice de Crecimiento de la Competitividad (ICC); "informe Global de Competitividad 2012-2013, World Economic Forum"; los principales indicadores macroeconómia del ...
Consejo Nacional de Ciencia y Tecnología (CONACYT)
core   +1 more source

Fortalecimiento del "programa hacia la CYMA". [PDF]

, 2013
El Programa "Hacia la Cyma" fue creado en 2009 por el Viceministerio de Ciencia y Tecnología a través de La Gerencia de Educación en Ciencia, tecnología e innovación, con la finalidad de apoyar el enriquecimiento curricular de los programas de estudio de
Consejo Nacional de Ciencia y Tecnología (CONACYT)
core  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Cronograma general de inversiones para la puesta en marcha de las propuestas. [PDF]

, 2013
Cronograma general de inversiones para la puesta en marcha de las propuestas del "Plan Nacional de Innovación, Ciencia y Tecnología -Plan ...
Consejo Nacional de Ciencia y Tecnología (CONACYT)
core  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Innate Immunocompetent hiPSC-Derived Neurospheroids Capture Early CNS Responses to rAAV. [PDF]

Adv Sci (Weinh)
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Gomes CM, Silva G, Aleixo M, Gomes M, Simão D, Holtkamp SJ, Lobo DD, Harish P, Jenkins R, Dahal LN, Nobre RJ, de Pereira de Almeida L, Trautwein M, Alves PM, Brito C.   +14 more
europepmc   +2 more sources

Programa de formación de doctores en ciencia exactas e ingeniería. [PDF]

, 2013
A partir de los estudios de prospectiva realizados en el marco de la consultaría, concretamente en el campo de los doctorados, se identificó en la línea de base, una limitada existencia de doctores que puedan contribuir al desarrollo académico, y en el a
Consejo Nacional de Ciencia y Tecnología (CONACYT)
core  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source