Results 11 to 20 of about 968,581 (231)
Educación Superior, Ciencia y Tecnología [PDF]
, 2020 Como citar el libro: Velasteguí López, E., Barono, López, L., Carrasco Ruano, T., & Velasteguí López, P. (2020). I Congreso en Educación Superior, Ciencia y Tecnología. Ciencia Digital Editorial.
Tatiana, Carrasco Ruano ; Revista Indexada Visioanrioa Digital +3 more
core +7 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Recomendaciones generales. [PDF]
, 2013 Recomendaciones generales del Estudio de factibilidad "Plan Nacional de Innovación, Ciencia y Tecnología-plan ICT" desde las perspectivas siguientes: Desde la perspectiva del fortalecimiento institucional, Sistema Nacional de Ciencia y Tecnología, de la ...
Consejo Nacional de Ciencia y Tecnología (CONACYT)
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Institucionalidad de innovación, ciencia y tecnología en El Salvador.
, 2013 La carpeta de propuesta de "Institucionalidad" hace un Diagnóstico de documentos como: El índice de Crecimiento de la Competitividad (ICC); "informe Global de Competitividad 2012-2013, World Economic Forum"; los principales indicadores macroeconómia del ...
Consejo Nacional de Ciencia y Tecnología (CONACYT)
core +1 more source
Fortalecimiento del "programa hacia la CYMA". [PDF]
, 2013 El Programa "Hacia la Cyma" fue creado en 2009 por el Viceministerio de Ciencia y Tecnología a través de La Gerencia de Educación en Ciencia, tecnología e innovación, con la finalidad de apoyar el enriquecimiento curricular de los programas de estudio de
Consejo Nacional de Ciencia y Tecnología (CONACYT)
core
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source