Results 21 to 30 of about 22,167,058 (263)
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Large scale analysis of protein conformational transitions from aqueous to non-aqueous media
BMC Bioinformatics, 2018 Background Biocatalysis in organic solvents is nowadays a common practice with a large potential in Biotechnology. Several studies report that proteins which are co-crystallized or soaked in organic solvents preserve their fold integrity showing almost ...
Ana Julia Velez Rueda +4 more
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Science and Technology of Advanced MaterialsWater splitting is a key technology for green hydrogen production, yet important challenges persist, particularly as large-scale expansion is expected, with seawater electrolysis emerging as a promising alternative to mitigate freshwater limitations ...
Lucía Muñiz Muñoz +8 more
doaj +1 more source
Recomendaciones generales. [PDF]
, 2013 Recomendaciones generales del Estudio de factibilidad "Plan Nacional de Innovación, Ciencia y Tecnología-plan ICT" desde las perspectivas siguientes: Desde la perspectiva del fortalecimiento institucional, Sistema Nacional de Ciencia y Tecnología, de la ...
Consejo Nacional de Ciencia y Tecnología (CONACYT)
core
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada +7 more
wiley +1 more source
Institucionalidad de innovación, ciencia y tecnología en El Salvador.
, 2013 La carpeta de propuesta de "Institucionalidad" hace un Diagnóstico de documentos como: El índice de Crecimiento de la Competitividad (ICC); "informe Global de Competitividad 2012-2013, World Economic Forum"; los principales indicadores macroeconómia del ...
Consejo Nacional de Ciencia y Tecnología (CONACYT)
core +1 more source
Discimus: Revista Digital de EducaciónEl artículo examina el impacto de las tecnologías de la información y comunicación (TIC) en la formación integral humana, especialmente en la educación sexual, la convivencia escolar y el desarrollo de competencias en la era digital.
Ana Lucia Peñaloza Jaimes +3 more
doaj +1 more source
Revista Minerva, 2023 Con el propósito de generar información objetiva sobre la composición y estructura general de la educación científica salvadoreña en los niveles de primaria y secundaria, ante la ausencia de fundamentos curriculares específicos y en el contexto de un ...
Tonatiuh Eddie Miguel Orantes-Ramos +4 more
doaj +1 more source