Results 11 to 20 of about 39,563 (66)

Genetic Dissection of Cyclic di‐GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption

open access: yesMicrobial Biotechnology, Volume 18, Issue 4, April 2025.
All 32 diguanylate cyclase (DGC)‐encoding genes of P. aeruginosa PA14 were interrupted by premature STOP codons, introduced through a multiplexed cytosine base‐editor. The synthesis of c‐di‐GMP was impaired in the resulting strain lacking all 32 DGCs (strain PA14Δ32). Phenotypic analysis confirmed major behaviour changes in P. aeruginosa PA14Δ32, which
Román A. Martino   +5 more
wiley   +1 more source

Estado nutricional, reproductivo y perfil alimentario en poblaciones peridomiciliarias de Triatoma infestans del departamento Cruz del Eje, provincia de Córdoba [PDF]

open access: yes, 2015
Fil: Soria, Carola. Consejo Nacional de Investigaciones Científicas y Técnicas Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.Fil: Soria, Carola. Universidad Nacional de Córdoba.
Canavoso, Lilián E.   +8 more
core  

Billion‐Scale Expansion of Functional hiPSC‐Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation

open access: yesAdvanced Science, Volume 12, Issue 11, March 20, 2025.
This work shows the development of a bioreactor‐based bioprocess for the expansion of human‐induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM), obtained after cardiac differentiation of hiPSC. By combining the activation of the Wnt pathway, through continuous perfusion of CHIR99021, with a controlled mild hypoxia environment, we maximize ...
Pedro Vicente   +16 more
wiley   +1 more source

Extreme Phenotypic Variability of ACTG1‐Related Disorders in Hearing Loss

open access: yesAdvanced Genetics, Volume 5, Issue 4, December 2024.
Different variants in a single gene can confer genetic pleiotropy (different phenotypes). One example is monoallelic variants in the ACTG1, coding for gamma (γ)‐actin, which is associated with classical Baraitser‐Winter Syndrome type 2 (BRWS2) and a variety of clinical presentations not fitting the original BRWS2 description including non‐syndromic ...
Maria T. Bernardi   +16 more
wiley   +1 more source

FreshLanDiv: A Global Database of Freshwater Biodiversity Across Different Land Uses

open access: yesGlobal Ecology and Biogeography, Volume 33, Issue 12, December 2024.
ABSTRACT Motivation Freshwater ecosystems have been heavily impacted by land‐use changes, but data syntheses on these impacts are still limited. Here, we compiled a global database encompassing 241 studies with species abundance data (from multiple biological groups and geographic locations) across sites with different land‐use categories.
Minghua Shen   +119 more
wiley   +1 more source

El paradigma de las concepciones alternativas y la formación de los profesores de ciencias [PDF]

open access: yes, 1994
The pre-service education of science teachers is empirically studied in the framework provided by the paradigm of alternative conceptions by means of 13 simple usual Physics questions.
Vázquez Alonso, Ángel
core   +2 more sources

MicroRNA‐1307‐3p contributes to breast cancer progression through PRM2

open access: yesThoracic Cancer, Volume 15, Issue 32, Page 2298-2308, November 2024.
The miR‐1307‐3p has oncogenic activity, as it leads to a decrease in PRM2 expression in breast cancer cells, which in turn promotes the proliferation of this pathology by inducing processes such as proliferation, migration, invasion, and angiogenesis.
José Roberto Estupiñan‐Jiménez   +14 more
wiley   +1 more source

PRESENCIA DE METALES PESADOS (ARSÉNICO Y MERCURIO) EN LECHE DE VACA AL SUR DE ECUADOR [PDF]

open access: yes, 2012
El presente trabajo fue desarrollado en el Cantón Arenillas, provincia de El Oro, al sur de Ecuador. El objetivo de este consistió en determinar la presencia de arsénico y mercurio en la leche que se comercializa y que es obtenida del ganado vacuno ...
Ayala Armijos, José   +1 more
core   +3 more sources

Reviewing mathematical models of sperm signaling networks

open access: yesMolecular Reproduction and Development, Volume 91, Issue 8, August 2024.
Abstract Dave Garbers’ work significantly contributed to our understanding of sperm's regulated motility, capacitation, and the acrosome reaction. These key sperm functions involve complex multistep signaling pathways engaging numerous finely orchestrated elements.
Daniel Priego Espinosa   +6 more
wiley   +1 more source

Cleavage of an engulfment peptidoglycan hydrolase by a sporulation signature protease in Clostridioides difficile

open access: yesMolecular Microbiology, Volume 122, Issue 2, Page 213-229, August 2024.
Model for the cleavage of SpoIIP by SpoIVB2 during sporulation in Clostridioides difficile. Soon after engulfment completion, SpoIVB2 cleaves SpoIIP, part of the engulfasome complex, to generate the SpoIIPc form. The function of SpoIVB2 is required for synthesis of the cortex layer which takes place across the outer forespore membrane.
Diogo Martins   +11 more
wiley   +1 more source

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