Results 41 to 50 of about 47,046 (175)
Magnetic Resonance in Chemistry, Volume 64, Issue 3, Page 324-332, March 2026.We report the results from a kinetic and mechanistic investigation of an inverse‐electron‐demand Diels–Alder (IEDDA) cycloaddition involving an oxazole‐type diene synthesized via an Ugi–Zhu multicomponent reaction (UZ‐3CR). ABSTRACT Pyridines are a crucial class of heterocycles with widespread applications in natural products, pharmaceuticals, and ...
Galdina V. Suárez‐Moreno +6 more
wiley +1 more source
Phytotherapy Research, Volume 40, Issue 1, Page 77-99, January 2026.ABSTRACT Flavonoids are natural secondary metabolites of plants with a basic composition derived from polyphenols that can produce a plethora of different neurophysiological effects, some of which are relevant to anxiety disorders. As such, many flavonoids have been evaluated in behavioral screens in preclinical research on anxiolytics.
Jhennify Albuquerque Machado +7 more
wiley +1 more source
Algevir: An Expression System for Microalgae Based on Viral Vectors
Frontiers in Microbiology, 2017 The use of recombinant algae for the production of valuable compounds is opening promising biotechnological applications. However, the development of efficient expression approaches is still needed to expand the exploitation of microalgae in ...
Bernardo Bañuelos-Hernández +7 more
doaj +1 more source
New Drug Design Avenues Targeting Alzheimer’s Disease by Pharmacoinformatics-Aided Tools
Pharmaceutics, 2022 Neurodegenerative diseases (NDD) have been of great interest to scientists for a long time due to their multifactorial character. Among these pathologies, Alzheimer’s disease (AD) is of special relevance, and despite the existence of approved drugs for ...
Lily Arrué +15 more
doaj +1 more source
ChemMedChem, Volume 20, Issue 22, November 18, 2025.The indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
Ledy De‐la‐Cruz‐Martínez +10 more
wiley +1 more source
Accessory Toxins of Vibrio Pathogens and Their Role in Epithelial Disruption During Infection
Frontiers in Microbiology, 2018 Gastrointestinal episodes associated with Vibrio species have been rising worldwide in the last few years. Consequently, it is important to comprehend how occurs the production of diarrhea, to establish new preventive and therapeutic measures.
Diliana Pérez-Reytor +5 more
doaj +1 more source
Una nueva identidad para los farmacéuticos : la Sociedad Farmacéutica Mexicana en el cambio de siglo (1890-1919) [PDF]
, 2007 La Sociedad Farmacéutica Mexicana fue fundada en 1871. En su interior los farmacéuticos se organizaron y apoyaron las tareas necesarias para el desarrollo de su profesión : elaborar una farmacopea, velar por los intereses y el mejoramiento de la ...
Aceves Pastrana, Patricia +2 more
core +3 more sources
Rol de variantes genéticas en el desarrollo de Enfermedad Renal Crónica en pacientes con Diabetes Mellitus Tipo 2 [PDF]
, 2018 La Enfermedad Renal Crónica (ERC) es una afección que perjudica a un gran número de pacientes. Una de las causas es la Nefropatía en pacientes con Diabetes Mellitus Tipo 2 (DM2).Objetivo: Indagar si la presencia de variantes genéticas contribuyen al ...
Ojeda, Verónica +3 more
core +1 more source
Ovarian Hormones and Addictive Behaviour Vulnerability: Insights From Preclinical Studies
Addiction Biology, Volume 30, Issue 6, June 2025.ABSTRACT Substance use disorder constitutes a global health challenge. Preclinical investigations into addiction heavily rely on animal models to explore the underlying biological mechanisms of addictive disorders, with a particular emphasis on understanding the etiological factors influencing drug intake.
Leonardo Vázquez‐Morales +6 more
wiley +1 more source
Revista de Salud Ambiental, 2018 En la actualidad es cada vez más necesario ubicar a la salud como un derecho humano ligado al desarrollo, esto requiere de la atención de múltiples factores, por lo cual ha dejado de ser una entidad exclusiva de la medicina.
Laura Ramírez-Landeros +7 more
doaj +2 more sources