Results 31 to 40 of about 46,684 (177)

Toxicología general y aplicada [PDF]

open access: yes, 2018
La toxicología es una ciencia en constante construcción. Desde sus inicios como ciencia ha estudiado las interacciones químicas y biológicas que ocurren entre los seres vivos y los xenobióticos o sustancias químicas ajenas al organismo que resultan en ...
Giannuzzi, Leda
core   +1 more source

Oxoisoaporphines and Aporphines: Versatile Molecules with Anticancer Effects

open access: yesMolecules, 2019
Cancer is a disease that involves impaired genome stability with a high mortality index globally. Since its discovery, many have searched for effective treatment, assessing different molecules for their anticancer activity.
Esteban Rodríguez-Arce   +4 more
doaj   +1 more source

Biofilm-forming microorganisms causing hospital-acquired infections from intravenous catheter: A systematic review

open access: yesCurrent Research in Microbial Sciences, 2022
The high prevalence of nosocomial infections is related to the use of medical insertion devices such as central venous catheters (CVCs). Most of the microorganisms causing nosocomial infections are biofilm producers, this characteristic allows them to ...
Sandra Pamela Cangui-Panchi   +5 more
doaj   +1 more source

Battle royale: Immune response on biofilms – host-pathogen interactions

open access: yesCurrent Research in Immunology, 2023
The research interest of the scientific community in biofilm-forming microorganisms is growing due to the problems caused by their infections affecting humans and animals, mainly because of the difficulty of the host immune system in eradicating these ...
Sandra Pamela Cangui-Panchi   +6 more
doaj   +1 more source

New Drug Design Avenues Targeting Alzheimer’s Disease by Pharmacoinformatics-Aided Tools

open access: yesPharmaceutics, 2022
Neurodegenerative diseases (NDD) have been of great interest to scientists for a long time due to their multifactorial character. Among these pathologies, Alzheimer’s disease (AD) is of special relevance, and despite the existence of approved drugs for ...
Lily Arrué   +15 more
doaj   +1 more source

Flavonoids as Anxiolytics in Animal Tests: Systematic Review, Meta‐Analysis, and Bibliometrical Analysis

open access: yesPhytotherapy Research, Volume 40, Issue 1, Page 77-99, January 2026.
ABSTRACT Flavonoids are natural secondary metabolites of plants with a basic composition derived from polyphenols that can produce a plethora of different neurophysiological effects, some of which are relevant to anxiety disorders. As such, many flavonoids have been evaluated in behavioral screens in preclinical research on anxiolytics.
Jhennify Albuquerque Machado   +7 more
wiley   +1 more source

Impact of Soil Nutrients on Chemical Composition and Antioxidant Activities of Dysphania ambrosioides Essential Oil in Southern Ecuador

open access: yesPlants
Dysphania ambrosioides is a widely distributed species with a traditional use in folk medicine, but it exhibits marked chemical variability that limits its standardization.
Susana Blacio   +5 more
doaj   +1 more source

Algevir: An Expression System for Microalgae Based on Viral Vectors

open access: yesFrontiers in Microbiology, 2017
The use of recombinant algae for the production of valuable compounds is opening promising biotechnological applications. However, the development of efficient expression approaches is still needed to expand the exploitation of microalgae in ...
Bernardo Bañuelos-Hernández   +7 more
doaj   +1 more source

Investigar para transformar [PDF]

open access: yes, 2011
La Universidad Andrés Bello ha definido su misión, orientándola para brindar a quienes aspiren a progresar, la posibilidad de una educación de calidad, integradora e inserta en un mundo global.
Universidad Andrés Bello
core  

Impact of C18 Epimerization of Indole‐ and Pyrazole‐Fused 18β‐Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies

open access: yesChemMedChem, Volume 20, Issue 22, November 18, 2025.
The indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
Ledy De‐la‐Cruz‐Martínez   +10 more
wiley   +1 more source

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