Results 41 to 50 of about 46,799 (176)

Impact of C18 Epimerization of Indole‐ and Pyrazole‐Fused 18β‐Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies

ChemMedChem, Volume 20, Issue 22, November 18, 2025.
The indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
Ledy De‐la‐Cruz‐Martínez, Rosendo Martínez‐Arellano, Mitzi López‐Sánchez, José G. Alvarado‐Rodríguez, Jesús Martin Torres‐Valencia, David Equihua‐González, Julio‐César Almanza‐Pérez, Jaime Pérez‐Villanueva, Martín González‐Andrade, José C. Páez‐Franco, Francisco Cortés‐Benítez   +10 more
wiley   +1 more source

Accessory Toxins of Vibrio Pathogens and Their Role in Epithelial Disruption During Infection

Frontiers in Microbiology, 2018
Gastrointestinal episodes associated with Vibrio species have been rising worldwide in the last few years. Consequently, it is important to comprehend how occurs the production of diarrhea, to establish new preventive and therapeutic measures.
Diliana Pérez-Reytor, Victor Jaña, Leonardo Pavez, Leonardo Pavez, Paola Navarrete, Katherine García   +5 more
doaj   +1 more source

Rol de variantes genéticas en el desarrollo de Enfermedad Renal Crónica en pacientes con Diabetes Mellitus Tipo 2 [PDF]

, 2018
La Enfermedad Renal Crónica (ERC) es una afección que perjudica a un gran número de pacientes. Una de las causas es la Nefropatía en pacientes con Diabetes Mellitus Tipo 2 (DM2).Objetivo: Indagar si la presencia de variantes genéticas contribuyen al ...
Ojeda, Verónica, Ruiz Pecchio, Adriana, Soria, Néstor Walter, Yang, Pablo   +3 more
core   +1 more source

Ovarian Hormones and Addictive Behaviour Vulnerability: Insights From Preclinical Studies

Addiction Biology, Volume 30, Issue 6, June 2025.
ABSTRACT Substance use disorder constitutes a global health challenge. Preclinical investigations into addiction heavily rely on animal models to explore the underlying biological mechanisms of addictive disorders, with a particular emphasis on understanding the etiological factors influencing drug intake.
Leonardo Vázquez‐Morales, Gisela Aguirre, Tania Molina‐Jiménez, Rossana C. Zepeda, Óscar López‐Franco, Mónica Flores‐Muñoz, Claudia Juárez‐Portilla   +6 more
wiley   +1 more source

Programas de ciencias ambientales y salud. Un nuevo profesional de salud para los nuevos escenarios de riesgo y vulnerabilidad

Revista de Salud Ambiental, 2018
En la actualidad es cada vez más necesario ubicar a la salud como un derecho humano ligado al desarrollo, esto requiere de la atención de múltiples factores, por lo cual ha dejado de ser una entidad exclusiva de la medicina.
Laura Ramírez-Landeros, Rogelio Flores Ramírez, Andrés Palacios, Evelyn Van Brussel, Donaji González-Mille, Moisés Vallejo Pérez, Claudia Paz, Fernando Díaz-Barriga Martínez   +7 more
doaj   +2 more sources

Acceso abierto en la Universidad Nacional de Rosario. Necesidades y prácticas de los docentes-investigadores. [PDF]

, 2014
El presente trabajo tiene como principal objetivo conocer las opiniones y prácticas de difusión en Acceso Abierto (AA) de los docentes/investigadores de la Universidad Nacional de Rosario (UNR), de la Argentina, y sus necesidades en relación con la ...
Babini, Dominique, Bongiovani, Paola Carolina, Guarnieri, Griselda, López, Fernando Ariel   +3 more
core  

Sugar diet affects Culex pipiens early‐life mortality, biochemical parameters, and immunocompetence

Ecosphere, Volume 16, Issue 4, April 2025.
Abstract Mosquitoes obtain carbohydrates from plants, providing a fundamental source of energy for their metabolism. These nutrients influence mosquito immunocompetence and longevity, which has potential implications for the transmission of mosquito‐borne pathogens.
Olaya García‐Ruiz, Juan Pascual‐Gil, Cristina Megías, Josué Martínez‐de la Puente, Jordi Figuerola, María José Ruiz‐López   +5 more
wiley   +1 more source

Genetic Dissection of Cyclic di‐GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption

Microbial Biotechnology, Volume 18, Issue 4, April 2025.
All 32 diguanylate cyclase (DGC)‐encoding genes of P. aeruginosa PA14 were interrupted by premature STOP codons, introduced through a multiplexed cytosine base‐editor. The synthesis of c‐di‐GMP was impaired in the resulting strain lacking all 32 DGCs (strain PA14Δ32). Phenotypic analysis confirmed major behaviour changes in P. aeruginosa PA14Δ32, which
Román A. Martino, Daniel C. Volke, Albano H. Tenaglia, Paula M. Tribelli, Pablo I. Nikel, Andrea M. Smania   +5 more
wiley   +1 more source

Current Knowledge in Planarian Glia and Its Future Implications in Modeling Neurodegenerative Diseases

Neuroglia
Neurodegenerative diseases are characterized by progressive loss of neurons and remain largely incurable. Numerous mammalian models have been developed to study the mechanisms underlying their physiopathology; however, their high cost, complexity and ...
David Gonzalez, Víctor Alarcón, Constanza Vásquez-Doorman   +2 more
doaj   +1 more source

Selenocysteine Formation by Enterococcus faecium ABMC-05 Follows a Mechanism That Is Not Dependent on Genes selA and selD but on Gene cysK

Fermentation, 2023
Lactic acid bacteria (LAB) resist sodium selenite of concentrations greater than 100 mg/L in fermentation media. Selenium affects the growth rate, but once the microorganism absorbs selenium, this element is converted through a complex mechanism into ...
Meyli Claudia Escobar-Ramírez, Gabriela Mariana Rodríguez-Serrano, Eduardo Zúñiga-León, Mario Adolfo García-Montes, Emmanuel Pérez-Escalante, Luis Guillermo González-Olivares   +5 more
doaj   +1 more source