Results 11 to 20 of about 52,278 (220)
Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària +12 morewiley +1 more sourceThe NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims
The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat +14 morewiley +1 more sourceJanus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis
Hepatology, EarlyView., 2022 Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims
Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein +21 morewiley +1 more sourceNatural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study
Hepatology, EarlyView., 2022 Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims
Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.Shannon M. Vandriel, Li‐Ting Li, Huiyu She, Jian‐She Wang, Melissa A. Gilbert, Irena Jankowska, Piotr Czubkowski, Dorota Gliwicz‐Miedzińska, Emmanuel M. Gonzales, Emmanuel Jacquemin, Jérôme Bouligand, Nancy B. Spinner, Kathleen M. Loomes, David A. Piccoli, Lorenzo D'Antiga, Emanuele Nicastro, Étienne Sokal, Tanguy Demaret, Noelle H. Ebel, Jeffrey A. Feinstein, Rima Fawaz, Silvia Nastasio, Florence Lacaille, Dominique Debray, Henrik Arnell, Björn Fischler, Susan Siew, Michael Stormon, Saul J. Karpen, Rene Romero, Kyung Mo Kim, Woo Yim Baek, Winita Hardikar, Sahana Shankar, Amin J. Roberts, Helen M. Evans, M. Kyle Jensen, Marianne Kavan, Shikha S. Sundaram, Alexander Chaidez, Palaniswamy Karthikeyan, Maria Camila Sanchez, Maria Lorena Cavalieri, Henkjan J. Verkade, Way Seah Lee, James E. Squires, Christina Hajinicolaou, Chatmanee Lertudomphonwanit, Ryan T. Fischer, Catherine Larson‐Nath, Yael Mozer‐Glassberg, Cigdem Arikan, Henry C. Lin, Jesus Quintero Bernabeu, Seema Alam, Deirdre A. Kelly, Elisa Carvalho, Cristina Targa Ferreira, Giuseppe Indolfi, Ruben E. Quiros‐Tejeira, Pinar Bulut, Pier Luigi Calvo, Zerrin Önal, Pamela L. Valentino, Dev M. Desai, John Eshun, Maria Rogalidou, Antal Dezsőfi, Sabina Wiecek, Gabriella Nebbia, Raquel Borges Pinto, Victorien M. Wolters, María Legarda Tamara, Andréanne N. Zizzo, Jennifer Garcia, Kathleen Schwarz, Marisa Beretta, Thomas Damgaard Sandahl, Carolina Jimenez‐Rivera, Nanda Kerkar, Jernej Brecelj, Quais Mujawar, Nathalie Rock, Cristina Molera Busoms, Wikrom Karnsakul, Eberhard Lurz, Ermelinda Santos‐Silva, Niviann Blondet, Luis Bujanda, Uzma Shah, Richard J. Thompson, Bettina E. Hansen, Binita M. Kamath, The Global ALagille Alliance (GALA) Study Group +93 morewiley +1 more sourceTranscript expression of vesicular glutamate transporters in lumbar dorsal root ganglia and the spinal cord of mice – Effects of peripheral axotomy or hindpaw inflammation [PDF]
, 2013 Using specific riboprobes, we characterized the expression of vesicular glutamate transporter (VGLUT)1–VGLUT3 transcripts in lumbar 4–5 (L4–5) dorsal root ganglions (DRGs) and the thoracolumbar to lumbosacral spinal cord in male BALB/c mice after a 1- or Brumovsky, Pablo Rodolfo, Gebhart, G. F., Hökfelt, T., Lundgren, K. H., Malet, Mariana, Seal, R. P., Seroogy, K. B., Tomasella, María Eugenia, Vieytes, C. A. +8 morecore +1 more sourceCD4+T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C viruscoinfected patients [PDF]
, 2017 To characterize peripheral blood natural killer (NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients.Cahn, Pedro, Laufer, Natalia Lorna, Martinez, Ana, Ojeda, Diego Sebastian, Polo, Maria Laura, Pérez, Héctor, Quarleri, Jorge Fabian, Turk, Gabriela Julia Ana, Zwirner, Norberto Walter +8 morecore +1 more sourceRab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate [PDF]
, 2015 During the late stages of the HIV-1 replication cycle, the viral polyprotein Pr55Gag is recruited to the plasma membrane (PM), where it binds phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and directs HIV-1 assembly.Balasubramaniam, Balla, Benaroch, Bennett, Berditchevski, Blott, Booth, Buchacher, Bussolino, Carolina Jancic, Carr, Catalina von Bilderling, Catarina Ferreira Moita, Checkley, Chen, Chesebro, Chu, Claudia Banchio, Cox, Deneka, Desnos, Dimitrov, Dong, Doughman, Eric O. Freed, Gabriel Duette, Genevieve de Saint Basile, Gould, Grigorov, Guo, Hammond, Hogue, Hume, Imai, Jolly, Jolly, Jorge Geffner, Joshi, Jouve, Jović, Kang, Kerviel, Krementsov, Krementsov, Li, Lloyd, Lorena Sigaut, Luciana Paoletti, Luis Ferreira Moita, Lía I. Pietrasanta, Manders, Matías Ostrowski, Mercedes Cabrini, Micucci, Minogue, Mlcochova, Moffat, Monde, Ménasché, Ménasché, Nakatsu, Naldini, Ono, Ostrowski, Pan, Pehuén Pereyra Gerber, Philippe Benaroch, Pizarro-Cerdá, Popovic, Raposo, Raposo, Ruiz-Mateos, Salazar, Satoh, Schindler, Sebastian Amigorena, Sibarita, Sundquist, Théry, Trkola, Tsuboi, Tsuboi, Vickers, Villalta, Várnai, Wang, Wei, Welsch, Yauch +88 morecore +1 more sourcePopulation Genetics of Franciscana Dolphins (Pontoporia blainvillei): Introducing a New Population from the Southern Edge of Their Distribution [PDF]
, 2015 Due to anthropogenic factors, the franciscana dolphin, Pontoporia blainvillei, is the most threatened small cetacean on the Atlantic coast of South America.A Dornburg, AB Sellas, AE Dizon, AJ Drummond, Alfredo Daniel Vitullo, APM Di Beneditto, AR Hoelzel, AR Hoelzel, AR Hoelzel, AR Rogers, AR Rogers, AR Rogers, Cristina Beatriz Dejean, Crowe GM O’Corry, D Charlesworth, D Posada, D Posada, E Valsecchi, EA Crespo, EA Crespo, EA Crespo, ER Secchi, ER Secchi, ER Secchi, ER Secchi, ER Secchi, F Rousset, F Tajima, GP Donovan, H Hamilton, HA Cunha, HA Lessios, HC Harpending, HJ Bandelt, HL Cappozzo, Humberto Luis Cappozzo, IC Ansmann, J Sambrook, JL Bossart, JL Jensen, JR Franklin, Juan Ignacio Túnez, KJ Fullard, KM Parsons, L Chen, L Excoffier, L Xu, LD Adams, M Failla, M Lázaro, M Mendez, M Mendez, MA Larkin, María Constanza Gariboldi, María Fernanda Negri, Mauricio Failla, MF Negri, N Ray, NJ Ouborg, P Berggren, P Bordino, P Bordino, P Librado, P Mardulyn, PE Rosel, PG Meirmans, R Frankham, R Nielsen, RS Waples, RS Wells, S Caballero, S Schneider, Sergios-Orestis Kolokotronis, SYW Ho, SYW Ho, SYW Ho, TD Kocher, TD Kocher, TL King, Urrutia P Costa, WS Grant, YX Fu +81 morecore +3 more sources
