Results 141 to 150 of about 256,965 (211)

Weakened Airway Epithelial Junctions and Enhanced Neutrophil Elastase Release Contribute to Age‐Dependent Bacteremia Risk Following Pneumococcal Pneumonia

Aging Cell, EarlyView.
During spread of Streptococcus pneumoniae from the lung to the bloodstream, the pneumococcal pore‐forming toxin pneumolysin (PLY) disrupts apical junction complexes (AJCs) and triggers the transmigration of polymorphonuclear leukocytes (PMNs), which secrete tissue‐destructive neutrophil elastase.
Shuying Xu, Tianmou Zhu, Hongmei Mou, Shumin Tan, John M. Leong   +4 more
wiley   +1 more source

KIF9 Ameliorates Neuropathology and Cognitive Dysfunction by Promoting Macroautophagy in a Mouse Model of Alzheimer's Disease

Aging Cell, EarlyView.
KIF9 is downregulated in AD, accompanied by dysfunction in macroautophagy. Genetic upregulation of KIF9 enhances macroautophagy by promoting KLC1‐mediated anterograde transport of lysosomes, which effectively reduces Aβ deposition and alleviates cognitive impairments in AD.
Maoju Wang, Song Guo, Lilin Yi, Zhaolun Li, Xiuyu Shi, YePeng Fan, Man Luo, Yan He, Weihong Song, Yehong Du, Zhifang Dong   +10 more
wiley   +1 more source

Theoretical analysis of Ellis fluid flow in two layers due to metachronal propulsion subject to heat and mass transfer: Application in biological function

Case Studies in Thermal Engineering
This study uses a metaphor to describe the motion of cilia with heat and mass transfer, and it highlights the importance of research for understanding biological function.
Sidra Shaheen, Hulin Huang, Fuad A.M. Al-Yarimi, Muhammad Bilal Arain   +3 more
doaj  

Development of an inhalable contrast agent targeting the respiratory tract mucus layer for pulmonary ultrasonic imaging

Scientific Reports
Impaired mucociliary transport is a distinguishing sign of cystic fibrosis, but current methods of evaluation are invasive or expose young patients to ionizing radiation. Contrast-enhanced ultrasound imaging may provide a feasible alternative.
James K. Tsuruta, Patrick R. Sears, Meghan E. Rebuli, Andrew S. Weitz, Phillip G. Durham, Phillip W. Clapp, David B. Hill, Lawrence E. Ostrowski, Paul A. Dayton, Melissa C. Caughey   +9 more
doaj   +1 more source

Realizing the physics of motile cilia synchronization with driven colloids

, 2015
Cilia and flagella in biological systems often show large scale cooperative behaviors such as the synchronization of their beats in "metachronal waves".
Bruot, Nicolas, Cicuta, Pietro
core   +1 more source

Acute Neuropsychiatric Decline in a Parkinson's Disease Patient with a Severe GBA1 Mutation Following Bilateral GPi Deep Brain Stimulation

Movement Disorders Clinical Practice, EarlyView.
Vijay G. Palakuzhy, Gian D. Pal, Mitra Afshari   +2 more
wiley   +1 more source

Transcriptional Heterogeneity and Differential Response of Rod Photoreceptor Pathway Uncovered by Single‐Cell RNA Sequencing of the Aging Mouse Retina

Aging Cell, EarlyView.
Healthy aging is accompanied by transcriptional dysregulation in retinal cells, leading to alterations in key molecular pathways and cellular responses, with the scotopic pathway being particularly affected. We show that rod photoreceptors, essential for initiating scotopic (low‐light) vision, exhibit selective vulnerability to aging‐associated ...
Laura Campello, Matthew J. Brooks, Benjamin R. Fadl, Hyo Sub Choi, Soumitra Pal, Anand Swaroop   +5 more
wiley   +1 more source

Aging‐Associated Vacuolation of Multi‐Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal Microenvironment

Aging Cell, EarlyView.
Multi‐ciliated cells in the infundibulum and ampulla (INF/AMP) epithelium are vacuolated in aging. Unique cellular susceptibility of the INF/AMP epithelial population and aging‐associated decline in ovarian artery circulation, which supports the ovary and INF/AMP, contribute to this region‐specific vacuolation phenotype, as a consequence of a mildly ...
Keerthana Harwalkar, Nobuko Yamanaka, Alain S. Pacis, Selina Zhao, Katie Teng, Warwick Pitman, Mitaali Taskar, Vera Lynn, Alex Frances Thornton, Matthew J. Ford, Yojiro Yamanaka   +10 more
wiley   +1 more source

Ciliary propulsion of objects in tubes: wall drag on swimming Tetrahymena (Ciliata) in the presence of mucin and other long-chain polymers [PDF]

, 1976
The lubrication effect of three long-chain polymers - mucin, methylcellulose and Ficoll - on ciliary propulsion in tubes is measured by plotting the relative velocities of swimming cilitates as a function of the tube bore diameter.
Winet, H.
core  

The impacts of e‐cigarette flavours: An overview of systematic reviews

Addiction, EarlyView.
Abstract Background and Aims E‐cigarette flavours have the potential to impact the appeal, harms and use of e‐cigarettes and combustible tobacco. Systematic reviews have synthesised evidence on their impacts but have always focused on specific outcomes or populations.
Jonathan Livingstone‐Banks, Nargiz Travis, Monserrat Conde, Yixian (Crystal) Chen, Padmo Zi, Holly Jarman, Nicola Lindson, Jamie Hartmann‐Boyce   +7 more
wiley   +1 more source