Results 181 to 190 of about 256,965 (211)
Experimental Physiology, EarlyView.Abstract The role of excessive airway constriction in the hyperresponsiveness to nebulized methacholine in mice with experimental asthma is still contentious. Yet, there have been very few studies investigating whether the increased in vivo response to methacholine caused by experimental asthma is associated with a corresponding increase in ex vivo ...
Andrés Rojas‐Ruiz +7 more
wiley +1 more source
Exploring neuronal mechanisms of osteosarcopenia in older adults
The Journal of Physiology, EarlyView.Abstract figure legend The mechanosensitive osteocytic network within the bone matrix acts as a receptor and plays a crucial role in the functional adaptation of bone to mechanical loading. Through mechanotransduction, osteocytes convert mechanical impulses into electrical signals, which are transmitted via afferent nerves to sympathetic preganglionic ...
Ilhan Karacan, Kemal Sıtkı Türker
wiley +1 more source
The apical mucus layer alters the pharmacological properties of the airway epithelium
The Journal of Physiology, EarlyView.Abstract figure legend In the airway epithelium, the cAMP‐activated cystic fibrosis transmembrane conductance regulator (CFTR) channel is a major pathway for chloride secretion. Its activity can potentially be evaluated by measuring the extent of chloride flux inhibition elicited by CFTR blockers, such as CFTRinh‐172 and PPQ‐102.
Daniela Guidone +5 more
wiley +1 more source
Mitochondrial control of ciliary gene expression and structure in striatal neurons
The Journal of Physiology, EarlyView.Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen +5 more
wiley +1 more source
American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.ABSTRACT Biallelic variants in GLDN have recently been associated with lethal congenital contracture syndrome 11 (LCCS11), a form of fetal akinesia deformation sequence (FADS) with high neonatal mortality. In this report, we describe five individuals from two Canadian Inuit families originating from different communities in Nunavik all affected with ...
Alexa McAdam +12 more
wiley +1 more source
Diagnosis and Treatment of Primary Tracheobronchial Tumors
Cancer Medicine, Volume 14, Issue 9, May 2025.ABSTRACT Background Primary tracheobronchial tumors (PTBTs) are rare but life‐threatening, accounting for approximately 0.2% of all respiratory neoplasms. Owing to their nonspecific clinical symptoms, PTBTs are often initially misdiagnosed as bronchial asthma or bronchitis in the early stages.
Chen Shu +9 more
wiley +1 more source
Glia, Volume 73, Issue 5, Page 1090-1106, May 2025.Main Points An astrocyte assay enhanced by IL‐6, IL‐17A, and IL‐10 distinguished NMOSD subtypes via AQP4 and C3d epitope expression. Clustering analyses revealed autoantibody‐specific patterns, highlighting diagnostic and therapeutic potential. ABSTRACT Neuromyelitis optica spectrum disorders (NMOSD) are severe autoimmune conditions affecting the ...
Marlen Alisch +11 more
wiley +1 more source
Role of Extracellular Vesicles in the Pathogenesis of Brain Metastasis
Journal of Extracellular Biology, Volume 4, Issue 5, May 2025.ABSTRACT Extracellular vesicles (EVs) are small particles released by various cells, including cancer cells. They play a significant role in the development of different cancers, including brain metastasis. These EVs transport biomolecular materials such as RNA, DNA, and proteins from tumour cells to other cells, facilitating the spread of primary ...
Muhammad Izhar, Maciej S. Lesniak
wiley +1 more source
Pulmonary MRI in Newborns and Children
Journal of Magnetic Resonance Imaging, Volume 61, Issue 5, Page 2094-2115, May 2025.Lung MRI is an important tool in the assessment and monitoring of pediatric and neonatal lung disorders. MRI can provide both similar and complementary image contrast to computed tomography for imaging the lung macrostructure, and beyond this, a number of techniques have been developed for imaging the key functions of the lungs, namely ventilation ...
Neil J. Stewart +8 more
wiley +1 more source
Organoid‐Guided Precision Medicine: From Bench to Bedside
MedComm, Volume 6, Issue 5, May 2025.This review focuses on the structural and characterization aspects of organoids derived from original cells and scaffold materials. It also examines the construction methodologies, the incorporation of cytokines, and the practical applications in precision medicine.
Boqaing Tao +12 more
wiley +1 more source