Results 41 to 50 of about 11,941 (146)

Three dimensional modeling of biologically relevant fluid shear stress in human renal tubule cells mimics in vivo transcriptional profiles

Scientific Reports, 2021
The kidney proximal tubule is the primary site for solute reabsorption, secretion and where kidney diseases can originate, including drug-induced toxicity.
Emily J. Ross, Emily R. Gordon, Hanna Sothers, Roshan Darji, Oakley Baron, Dustin Haithcock, Balabhaskar Prabhakarpandian, Kapil Pant, Richard M. Myers, Sara J. Cooper, Nancy J. Cox   +10 more
doaj   +1 more source

Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

Stem Cell Reports, 2016
Multi-ciliated airway cells (MCACs) play a role in mucociliary clearance of the lung. However, the efficient induction of functional MCACs from human pluripotent stem cells has not yet been reported.
Satoshi Konishi, Shimpei Gotoh, Kazuhiro Tateishi, Yuki Yamamoto, Yohei Korogi, Tadao Nagasaki, Hisako Matsumoto, Shigeo Muro, Toyohiro Hirai, Isao Ito, Sachiko Tsukita, Michiaki Mishima   +11 more
doaj   +1 more source

Significant mathematical deductions of the double-diffusive convection on the Sisko fluid dynamics model driven by peristaltic movement within ciliated channel

International Journal of Thermofluids
This study mainly focuses on mathematical modeling of Sisko fluid through peristaltic propagation with ciliated channel walls for magnetically induced flow, including double-diffusive convection.
Muhammad Bilal Riaz, S. Bilal, Ayesha Saddiqa, Lubna Sarwar   +3 more
doaj   +1 more source

Multiple cell types in the oviduct express the prolactin receptor

FASEB BioAdvances, 2022
Little is known about the physiological role of prolactin in the oviduct. Examining mRNA for all four isoforms of the prolactin receptor (PRLR) in mice by functional oviduct segment and stage of the estrous cycle, we found short form 3 (SF3) to be the ...
Kelly C. Radecki, Matthew J. Ford, Hollian R. Phillipps, Mary Y. Lorenson, David R. Grattan, Yojiro Yamanaka, Ameae M. Walker   +6 more
doaj   +1 more source

Electroosmotically actuated peristaltic-ciliary flow of propylene glycol + water conveying titania nanoparticles

Scientific Reports, 2023
The main focus of this article is to mathematically formulate the microfluidics-based mechanical system for nanofluids. A 50:50 mixture of propylene glycol (PG) and water is used as a heat transfer fluid because of its tremendous anti-freezing properties,
Javaria Akram, Noreen Sher Akbar
doaj   +1 more source

Theoretical analysis of Ellis fluid flow in two layers due to metachronal propulsion subject to heat and mass transfer: Application in biological function

Case Studies in Thermal Engineering
This study uses a metaphor to describe the motion of cilia with heat and mass transfer, and it highlights the importance of research for understanding biological function.
Sidra Shaheen, Hulin Huang, Fuad A.M. Al-Yarimi, Muhammad Bilal Arain   +3 more
doaj   +1 more source

Vertebrate Left-Right Asymmetry: What Can Nodal Cascade Gene Expression Patterns Tell Us?

Journal of Cardiovascular Development and Disease, 2017
Laterality of inner organs is a wide-spread characteristic of vertebrates and beyond. It is ultimately controlled by the left-asymmetric activation of the Nodal signaling cascade in the lateral plate mesoderm of the neurula stage embryo, which results ...
Axel Schweickert, Tim Ott, Sabrina Kurz, Melanie Tingler, Markus Maerker, Franziska Fuhl, Martin Blum   +6 more
doaj   +1 more source

Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. [PDF]

PLoS ONE, 2017
We have previously established a link between impaired phagocytic capacity and deregulated S1P signaling in alveolar macrophages from COPD subjects. We hypothesize that this defect may include a disruption of epithelial-macrophage crosstalk via Spns2 ...
Hai B Tran, Hubertus Jersmann, Tung Thanh Truong, Rhys Hamon, Eugene Roscioli, Miranda Ween, Melissa R Pitman, Stuart M Pitson, Greg Hodge, Paul N Reynolds, Sandra Hodge   +10 more
doaj   +1 more source

Atypical calcium regulation of the PKD2-L1 polycystin ion channel

eLife, 2016
Native PKD2-L1 channel subunits are present in primary cilia and other restricted cellular spaces. Here we investigate the mechanism for the channel's unusual regulation by external calcium, and rationalize this behavior to its specialized function.
Paul G DeCaen, Xiaowen Liu, Sunday Abiria, David E Clapham   +3 more
doaj   +1 more source

Cilia-assisted flow for the Johnson–Segalman fluid inside a convergent complex wavy passage with the magnetic field, hall effect, and porous medium

Kuwait Journal of Science
This study investigates the cilia-driven flow of a Johnson–Segalman (J–S) non-Newtonian fluid through a two-dimensional converging channel under the influence of a vertically applied magnetic field. The problem is motivated by its relevance to biological
Muhammad Waris Saeed Khan, Zeeshan Asghar, Wasfi Shatanawi, Muhammad Asif Gondal   +3 more
doaj   +1 more source