Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. [PDF]
PLoS ONE, 2017 We have previously established a link between impaired phagocytic capacity and deregulated S1P signaling in alveolar macrophages from COPD subjects. We hypothesize that this defect may include a disruption of epithelial-macrophage crosstalk via Spns2 ...
Hai B Tran +10 more
doaj +1 more source
Asymmetric motion of magnetically actuated artificial cilia [PDF]
Lab Chip, 2017,17, 3138-3145, 2018 Most microorganisms use hair-like cilia with asymmetric beating to perform vital bio-physical processes. In this paper, we demonstrate a novel fabrication method for creating magnetic artificial cilia capable of such biologically inspired asymmetrical beating pattern essential for creating microfluidic transport in low Reynolds number.
arxiv +1 more source
Basal body stability and ciliogenesis requires the conserved component Poc1 [PDF]
, 2009 Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule ...
Abal +87 more
core +2 more sources
Programmable metachronal motion of densely packed magnetic artificial cilia [PDF]
arXiv, 2023 Despite recent advances in artificial cilia technologies, the application of metachrony, which is the collective wavelike motion by cilia moving out-of-phase, has been severely hampered by difficulties in controlling densely packed artificial cilia at micrometer length scales. Moreover, there has been no direct experimental proof yet that a metachronal
arxiv
A boundary element regularised Stokeslet method applied to cilia and flagella-driven flow [PDF]
Proceedings of the Royal Society of London Series A, 465,
3605-3626 (2009), 2010 A boundary element implementation of the regularised Stokeslet method of Cortez is applied to cilia and flagella-driven flows in biology. Previously-published approaches implicitly combine the force discretisation and the numerical quadrature used to evaluate boundary integrals.
arxiv +1 more source
Immotile cilia of the mouse node sense a fluid flow–induced mechanical force for left-right symmetry breaking [PDF]
, 2022 Takanobu A. Katoh +14 more
openalex +1 more source
Collective beating of artificial microcilia
, 2011 We combine technical, experimental and theoretical efforts to investigate the collective dynamics of artificial microcilia in a viscous fluid. We take advantage of soft-lithography and colloidal self-assembly to devise microcapets made of hundreds of ...
Antoine Bricard +8 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.The present study investigates the role of the NLRP3 inflammasome in the chronicity of ocular inflammation in uveitis using the experimental autoimmune uveitis (EAU) model. Whole eyes collected from EAU mice, 12 weeks post induction, were sectioned and subjected to immunohistochemistry. The confocal images from these sections were then assessed for the
Avik Shome +3 more
wiley +1 more source
Fluid transport at low Reynolds number with magnetically actuated artificial cilia [PDF]
, 2008 By numerical modeling we investigate fluid transport in low-Reynolds-number flow achieved with a special elastic filament or artifical cilium attached to a planar surface. The filament is made of superparamagnetic particles linked together by DNA double strands.
arxiv +1 more source
Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]
, 2016 The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina +8 more
core +2 more sources