Results 91 to 100 of about 16,012 (313)

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source

Numerical and functional response of phagotrophic aquatic protists: the ideal experiment—and why we cannot get it

Frontiers in Microbiology
Protists are paramount for biogeochemical cycling in every aquatic ecosystem due to their vast population sizes and physiological versatility. Numerical response (NR) and functional response (FR) experiments are cornerstones of trait-based functional ...
Thomas Weisse
doaj   +1 more source

New Records of Thecacineta cothurnioides and Trematosoma rotunda (Ciliophora, Suctorea) as epibionts on nematodes from the Indian Ocean

, 2009
This article deals with the report of two suctorian ciliates species viz. Thecacineta cothurnioides Collin, 1909 and Trematosoma rotunda (Allgén, 1952 ) as epibionts on Tricoma sp. and Pseudochromadora sp.
Ingole Baban, Chatterjee Taras, Dovgal I. V.   +2 more
core  

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

BIOASSAY OF ORGANIC SOIL POLLUTION DEGREE USING CILIATES PEDOBIONTS IN AZERBAIJAN

Юг России: экология, развитие, 2017
Aim. It is known that free-living ciliates quickly react to the slightest changes in environmental conditions. This feature of physiological reactions on the basis of long-term studies made it possible to use some species of free-living ciliates to ...
I. Kh. Alekperov, V. F. Mamedova
doaj   +1 more source

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Prevalence of partnerships between bacteria and ciliates in oxygen-depleted marine water columns

Frontiers in Microbiology, 2012
Symbioses between Bacteria, Archaea, and Eukarya in deep-sea marine environments represent a means for eukaryotes to exploit otherwise inhospitable habitats.
William D Orsi, Sophie eCharvet, Peter eVdacny, Joan M Bernhard, Virginia P Edgcomb   +4 more
doaj   +1 more source

Integrating the 3 Dimensions of Biodiversity: New Standards for Documenting Biodiversity of Ciliates and Strategies for Accessing and Sharing Data [PDF]

, 2014
Title: Ciliate biodiversity studies in Italy - DIVERSITY AND BIOINDICATIVE VALUE OF SOIL CILIATE COMMUNITIES • Soil ciliate studies in Italy......from past to present!
LA TERZA, Antonietta
core