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Cimetidine: An Immunomodulator
DICP, 1990Suppressor T lymphocytes possess histamine2 (H2) receptors and contribute significantly to the function of the immune system. Experimentally, cimetidine, an H2-receptor antagonist, has been shown to enhance a variety of immunologic functions both in vivo and in vitro because of its inhibitory effects on suppressor-cell function.
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Cimetidine and Granulocytopenia
Annals of Internal Medicine, 1979Excerpt Cimetidine already is used extensively in the United States and abroad. This histamine H2-receptor antagonist was approved by the Food and Drug Administration (FDA) in August 1977 for the t...
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Human Toxicology, 1985
1 Cimetidine has been shown to have low acute toxicity in dogs and rodents. Repeated-dose studies of up to 24 months' duration in rodents at doses up to 950 mg day kg-1showed few adverse effects. Liver weight was consistently increased at the highest dose and testis, prostate and seminal vesicle weights were reduced in a dose- and time-related fashion.
T.F. Walker +2 more
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1 Cimetidine has been shown to have low acute toxicity in dogs and rodents. Repeated-dose studies of up to 24 months' duration in rodents at doses up to 950 mg day kg-1showed few adverse effects. Liver weight was consistently increased at the highest dose and testis, prostate and seminal vesicle weights were reduced in a dose- and time-related fashion.
T.F. Walker +2 more
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Cimetidine and Hypersensitivity
Annals of Internal Medicine, 1983Excerpt To the editor: We write in reply to comments by Leftwich and Simon (1) on our report (2) of a patient with type I hypersensitivity to cimetidine (Tagamet; Smith, Kline & French, Philadelphi...
Baldev S. Sandhu, Ramiro Requena
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Archives of Internal Medicine, 1986
To the Editor. —The recent article in theArchivesby Lardinois and Mazzaferri1('Cimetidine Blocks Testosterone Synthesis') contains implications and misstatements that have been misleading to your readers. As the authors point out, the changes in plasma testosterone levels noted in their patient are unique and have not previously been reported with ...
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To the Editor. —The recent article in theArchivesby Lardinois and Mazzaferri1('Cimetidine Blocks Testosterone Synthesis') contains implications and misstatements that have been misleading to your readers. As the authors point out, the changes in plasma testosterone levels noted in their patient are unique and have not previously been reported with ...
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Scandinavian Journal of Gastroenterology, 1986
The actions of cimetidine are well known: an inhibitor of gastrin hydrochloric secretion, cimetidine modifies neither the motility nor any of the other functional factors. Numerous authors also attribute a cytoprotective role to cimetidine, one that is apparently carried out independently of the inhibitory effect on hydrochloric secretion.
M C Parodi, Molinari F, Cheli R
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The actions of cimetidine are well known: an inhibitor of gastrin hydrochloric secretion, cimetidine modifies neither the motility nor any of the other functional factors. Numerous authors also attribute a cytoprotective role to cimetidine, one that is apparently carried out independently of the inhibitory effect on hydrochloric secretion.
M C Parodi, Molinari F, Cheli R
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Journal of Clinical Gastroenterology, 1986
A 62-year-old man developed asymptomatic anicteric hepatitis during cimetidine therapy for duodenal ulcer disease. Liver biopsy revealed zonal (centrolobular) necrosis, bile stasis, and mononuclear cell infiltration. Electron microscopy featured mitochondrial hyperplasia, giant mitochondria, and liver cell bile inclusions.
J T, Schwartz, F, Gyorkey, D Y, Graham
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A 62-year-old man developed asymptomatic anicteric hepatitis during cimetidine therapy for duodenal ulcer disease. Liver biopsy revealed zonal (centrolobular) necrosis, bile stasis, and mononuclear cell infiltration. Electron microscopy featured mitochondrial hyperplasia, giant mitochondria, and liver cell bile inclusions.
J T, Schwartz, F, Gyorkey, D Y, Graham
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Annals of Internal Medicine, 1983
Ranitidine, a new H2-receptor blocking antihistamine, is pharmacokinetically similar to cimetidine, but its potency is about eightfold greater. The clinical response to ranitidine is more prolonged, largely because of potency and not kinetic advantage.
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Ranitidine, a new H2-receptor blocking antihistamine, is pharmacokinetically similar to cimetidine, but its potency is about eightfold greater. The clinical response to ranitidine is more prolonged, largely because of potency and not kinetic advantage.
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Pediatrics, 1980
In the recent report by Chhattriwalla and colleagues (The use of cimetidine in the newborn. Pediatrics 65:301, 1980) no toxic side effects were observed in three infants during cimetidine treatment. The authors referenced several reports of cimetidine toxicity in adults but did not discuss previously reported studies in children.
J R, Lilly, P, Murr, C, Pau
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In the recent report by Chhattriwalla and colleagues (The use of cimetidine in the newborn. Pediatrics 65:301, 1980) no toxic side effects were observed in three infants during cimetidine treatment. The authors referenced several reports of cimetidine toxicity in adults but did not discuss previously reported studies in children.
J R, Lilly, P, Murr, C, Pau
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JAMA: The Journal of the American Medical Association, 1978
S, Karpow, V, Gotz, R D, Lauper
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S, Karpow, V, Gotz, R D, Lauper
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