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Guanidines: Privileged Scaffolds Against Neglected Tropical Diseases: A Review [PDF]

Pharmaceuticals
Background: Neglected diseases caused by protozoan parasites remain a major public health burden, particularly in low- and middle-income countries. Among the chemical motifs explored in antiparasitic drug discovery, guanidine-containing compounds have ...
Luana Ribeiro dos Anjos, Rodrigo Santos Aquino de Araújo, Malu Maria Lucas dos Reis, Natalia C. S. Costa, Vitória Gaspar Bernardo, Eduardo Henrique Zampieri, Klinger Antonio da Franca Rodrigues, Eduardo Maffud Cilli, Eduardo René Pérez González, Francisco Jaime Bezerra Mendonça-Junior   +9 more
doaj   +2 more sources

Mechanistic DFT Study of 1,3-Dipolar Cycloadditions of Azides with Guanidine

Molecules, 2023
Density functional calculations SMD(chloroform)//B3LYP/6-311+G(2d,p) were employed in the computational study of 1,3-dipolar cycloadditions of azides with guanidine.
Ivana Antol, Zoran Glasovac, Davor Margetić   +2 more
doaj   +1 more source

Guanidinates as Alternative Ligands for Organometallic Complexes

Molecules, 2022
For decades, ligands such as phosphanes or cyclopentadienyl ring derivatives have dominated Coordination and Organometallic Chemistry. At the same time, alternative compounds have emerged that could compete either for a more practical and accessible ...
Fernando Carrillo-Hermosilla, Rafael Fernández-Galán, Alberto Ramos, David Elorriaga   +3 more
doaj   +1 more source

Amino Acylguanidines as Bioinspired Catalysts for the Asymmetric Aldol Reaction

Molecules, 2021
The binding and stabilizing effect of arginine residues in certain aldolases served as inspiring source for the development of a family of amino acylguanidine organocatalysts.
Ciril Jimeno
doaj   +1 more source

Novel Selective and Low-Toxic Inhibitor of LmCPB2.8ΔCTE (CPB) One Important Cysteine Protease for Leishmania Virulence

Biomolecules, 2022
Leishmaniasis is a highly prevalent, yet neglected disease caused by protozoan parasites of the genus Leishmania. In the search for newer, safer, and more effective antileishmanial compounds, we herein present a study of the mode of action in addition to
Vitor Partite Moreira, Michele Ferreira da Silva Mela, Luana Ribeiro dos Anjos, Leonardo Figueiredo Saraiva, Angela M. Arenas Velásquez, Predrag Kalaba, Anna Fabisiková, Leandro da Costa Clementino, Mohammed Aufy, Christian Studenik, Natalie Gajic, Alexander Prado-Roller, Alvicler Magalhães, Martin Zehl, Ingrid Delbone Figueiredo, Amanda Martins Baviera, Eduardo Maffud Cilli, Marcia A. S. Graminha, Gert Lubec, Eduardo R. Perez Gonzalez   +19 more
doaj   +1 more source

Investigation of the Phytochemical Composition, Antioxidant Activity, and Methylglyoxal Trapping Effect of Galega officinalis L. Herb In Vitro

Molecules, 2020
Galega officinalis L. has been known for centuries as an herbal medicine used to alleviate the symptoms of diabetes, but its comprehensive chemical composition and pharmacological activity are still insufficiently known.
Katarzyna Bednarska, Piotr Kuś, Izabela Fecka   +2 more
doaj   +1 more source

Synthesis of (+)-(R)-Tiruchanduramine

Molecules, 2022
The absolute stereochemistry of the marine alkaloid (+)-(R)-tiruchanduramine was established via a convergent total synthesis in six steps and 15.5% overall yield from Fmoc-D-Dab(Boc)-OH.
Zahraa S. Al-Taie, Barbara Bartholomew, Christopher Cartmell, Richard T. Froom, Russell G. Kerr, Rolf Kraehenbuehl, Patrick J. Murphy, Robert J. Nash, Yana B. Penkova, Alexander van Teijlingen   +9 more
doaj   +1 more source

Guanidines: Synthesis of Novel Histamine H₃R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect

Pharmaceuticals, 2023
This study examines the properties of novel guanidines, designed and synthesized as histamine H3R antagonists/inverse agonists with additional pharmacological targets.
Marek Staszewski, Magdalena Iwan, Tobias Werner, Marek Bajda, Justyna Godyń, Gniewomir Latacz, Agnieszka Korga-Plewko, Joanna Kubik, Natalia Szałaj, Holger Stark, Barbara Malawska, Anna Więckowska, Krzysztof Walczyński   +12 more
doaj   +1 more source

2-((1H-Benzo[d]imidazol-2-yl)amino)benzo[d]thiazole-6-sulphonamides: a class of carbonic anhydrase II and VII-selective inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A small library of substituted cyclic guanidine incorporated benzothiazole-6-sulphonamides was synthesized. All obtained compounds were investigated for their inhibitory activity against the key brain-associated human carbonic anhydrase isoform hCA VII ...
Morteza Abdoli, Claudiu T. Supuran, Raivis Žalubovskis   +2 more
doaj   +1 more source

Synthesis of Guanidines via Reaction of Amines with Carbodiimides in the Presence of Ionic Liquid

Journal of the Turkish Chemical Society, Section A: Chemistry, 2016
Different ionic liquids (ILs) were synthesized and evaluated for the preparation of substituted guanidines from the reaction of amines and carbodiimides.
Foad Shaghayeghi Toosi
doaj   +1 more source