Results 1 to 10 of about 6,529 (298)
Mechanochemical synthesis of thioureas, ureas and guanidines
Beilstein Journal of Organic Chemistry, 2017 In this review, the recent progress in the synthesis of ureas, thioureas and guanidines by solid-state mechanochemical ball milling is highlighted. While the literature is abundant on their preparation in conventional solution environment, it was not ...
Vjekoslav Štrukil
exaly +4 more sources
Biological Effects of Novel Synthetic Guanidine Derivatives Targeting Leishmania (Viannia) braziliensis [PDF]
MoleculesLeishmaniasis remains an important neglected tropical disease, and current treatments are limited by toxicity, resistance, and low bioavailability. In this study, novel guanidine derivatives were evaluated through an integrated approach, combining in ...
Geovane Dias-Lopes +8 more
doaj +2 more sources
Lipophilic mono-guanidines versus mono-(thio)ureas: anion transport, lipid binding, and antibacterial activity [PDF]
RSC AdvancesSynthetic anion transporters (anionophores) can collapse ion gradients and have been widely explored as candidate therapeutics for channelopathies and cancer, yet their potential as antibacterial agents remains comparatively underdevelopped.
Randima D. De Silva Weerakonda Arachchige +3 more
doaj +2 more sources
Guanidines: Privileged Scaffolds Against Neglected Tropical Diseases: A Review [PDF]
PharmaceuticalsBackground: Neglected diseases caused by protozoan parasites remain a major public health burden, particularly in low- and middle-income countries. Among the chemical motifs explored in antiparasitic drug discovery, guanidine-containing compounds have ...
Luana Ribeiro dos Anjos +9 more
doaj +2 more sources
Mechanistic DFT Study of 1,3-Dipolar Cycloadditions of Azides with Guanidine
Molecules, 2023 Density functional calculations SMD(chloroform)//B3LYP/6-311+G(2d,p) were employed in the computational study of 1,3-dipolar cycloadditions of azides with guanidine.
Ivana Antol +2 more
doaj +1 more source
Guanidinates as Alternative Ligands for Organometallic Complexes
Molecules, 2022 For decades, ligands such as phosphanes or cyclopentadienyl ring derivatives have dominated Coordination and Organometallic Chemistry. At the same time, alternative compounds have emerged that could compete either for a more practical and accessible ...
Fernando Carrillo-Hermosilla +3 more
doaj +1 more source
Synthesis of (+)-(R)-Tiruchanduramine
Molecules, 2022 The absolute stereochemistry of the marine alkaloid (+)-(R)-tiruchanduramine was established via a convergent total synthesis in six steps and 15.5% overall yield from Fmoc-D-Dab(Boc)-OH.
Zahraa S. Al-Taie +9 more
doaj +1 more source
Pharmaceuticals, 2023 This study examines the properties of novel guanidines, designed and synthesized as histamine H3R antagonists/inverse agonists with additional pharmacological targets.
Marek Staszewski +12 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 A small library of substituted cyclic guanidine incorporated benzothiazole-6-sulphonamides was synthesized. All obtained compounds were investigated for their inhibitory activity against the key brain-associated human carbonic anhydrase isoform hCA VII ...
Morteza Abdoli +2 more
doaj +1 more source
Amino Acylguanidines as Bioinspired Catalysts for the Asymmetric Aldol Reaction
Molecules, 2021 The binding and stabilizing effect of arginine residues in certain aldolases served as inspiring source for the development of a family of amino acylguanidine organocatalysts.
Ciril Jimeno
doaj +1 more source