Results 31 to 40 of about 16,174 (328)

One-pot synthesis of dihydropyrimidines via eco-friendly phosphorus derivatives catalysis

Journal of Saudi Chemical Society, 2022
A straightforward, cost effective and eco-friendly protocol for the Biginelli reaction relying on the use of readily available hypophosphorous acid is presented.
Zakaria Moutaoukil, Cyril Ronco, Rachid Benhida   +2 more
doaj   +1 more source

Enantioselective Synthesis of Succinimides by Michael Addition of Aldehydes to Maleimides Organocatalyzed by Chiral Primary Amine-Guanidines [PDF]

, 2013
The monoguanylation of (1S,2S)- and (1R,2R)-cyclohexane-1,2-diamine affords chiral primary amine-guanidines that are used as chiral organocatalysts in the enantioselective Michael addition of aldehydes, particularly α,α-disubstituted aldehydes, to ...
Chinchilla, Rafael, Gómez Bengoa, Enrique, Nájera, Carmen, Ávila Freire, Ángel   +3 more
core   +2 more sources

X-ray Structure of Eleven New N,N′-Substituted Guanidines: Effect of Substituents on Tautomer Structure in the Solid State

Crystals
Guanidine-containing molecules are an interesting class of compounds within both medicinal and material sciences. Having knowledge of their tautomerism is key in designing guanidines that interact with biological and chemical receptors.
Vijayaragavan Elumalai, Vaclav Eigner, Nicholas Alexander Janjua, Per-Olof Åstrand, Torkild Visnes, Eirik Sundby, Bård Helge Hoff   +6 more
doaj   +1 more source

Norbornane-based antibacterial agents: Benzyl and benzoyl substituted guanidines

European Journal of Medicinal Chemistry Reports, 2022
There is a pressing need to develop new antibiotics to replace those rendered ineffective as a result of widespread antimicrobial resistance. Naturally occurring cationic antimicrobial peptides (CAMPs) exhibit broad-spectrum antibacterial activity and ...
Gareth E. Boer, Shane M. Hickey, Alysha G. Elliott, Frederick M. Pfeffer   +3 more
doaj   +1 more source

Guanidine Chemistry

Chemical and Pharmaceutical Bulletin, 2010
Guanidines are categorized as strong organobases; however, their catalytic utility in organic synthesis has not been discussed thoroughly. The author's group has extensively and systematically studied their potential ability focusing on: 1) modified guanidines as chiral auxiliaries; 2) guanidinium ylides for aziridine formation; 3) the affinity of ...
openaire   +3 more sources

Development of a Promising Method for Producing Oligomeric Mixture of Branched Alkylene Guanidines to Improve Substance Quality and Evaluate Their Antiviral Activity against SARS-CoV-2

Molecules, 2021
This paper reports the synthesis of branched alkylene guanidines using microfluidic technologies. We describe the preparation of guanidine derivatives at lower temperatures, and with significantly less time than that required in the previously applicable
Denis O. Shatalov, Stanislav A. Kedik, Ivan S. Ivanov, Anna V. Aydakova, Diana A. Akhmedova, Dmitrii S. Minenkov, Sergei V. Beliakov, Alexander Herbst, Lasse Greiner, Liubov I. Kozlovskaya, Viktor P. Volok   +10 more
doaj   +1 more source

Biological Effects of Novel Synthetic Guanidine Derivatives Targeting Leishmania (Viannia) braziliensis

Molecules
Leishmaniasis remains an important neglected tropical disease, and current treatments are limited by toxicity, resistance, and low bioavailability. In this study, novel guanidine derivatives were evaluated through an integrated approach, combining in ...
Geovane Dias-Lopes, Luana Ribeiro Dos Anjos, Sara Maria Xavier da Cruz, Cauã Dias Abrão, Maria Eduarda Pinto Gonçalves, Franklin Souza-Silva, Anna Fabisikova, Eduardo Rene Perez González, Carlos Roberto Alves   +8 more
doaj   +1 more source

Design and synthesis of a photoswitchable guanidine catalyst

Beilstein Journal of Organic Chemistry, 2012
A novel design as well as a straight-forward synthesis for a photoswitchable guanidine catalyst is reported. Intense studies of the photochromic properties demonstrated the reversible switchability of its photosensitive azobenzene moiety. Its activity in
Philipp Viehmann, Stefan Hecht
doaj   +1 more source

Eco-friendly methods of synthesis and preliminary biological evaluation of sulfonamide derivatives of cyclic arylguanidines

Ultrasonics Sonochemistry, 2022
The chemotype of arylsulfonamide derivatives of cyclic arylguanidines is a source of molecules with valuable biological activities, including antimicrobial and antitumor properties.
Przemysław Zaręba, Anna K. Drabczyk, Artur Wnorowski, Edyta Pindelska, Gniewomir Latacz, Jolanta Jaśkowska   +5 more
doaj   +1 more source

Biochemical and clinical impact of organic uremic retention solutes : a comprehensive update [PDF]

, 2018
In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized.
Abel, Amann, Anneleen Pletinck, Barreto, Brownlee, Cohen, Costigan, Dhaun, Drewett, Eva Schepers, Glorieux, Griet Glorieux, Hannam-Harris, Harpel, Henderson, Hur, Kassis, Kohan, Koizumi, Kuragano, Lim, Nilsson, Niwa, Niwa, Palmer, Patel, Raymond Vanholder, Rhee, Rock, Rubin, Saxena, Sheriff, Simenhoff, Tschesche, Vadas, Vallance, Vanholder, Vanholder, Vanholder, Vannucchi, Ward, Warren, Witko-Sarsat, Yan, Zoccali, Zoccali   +45 more
core   +3 more sources