Results 31 to 40 of about 6,045 (297)
Norbornane-based antibacterial agents: Benzyl and benzoyl substituted guanidines
European Journal of Medicinal Chemistry Reports, 2022 There is a pressing need to develop new antibiotics to replace those rendered ineffective as a result of widespread antimicrobial resistance. Naturally occurring cationic antimicrobial peptides (CAMPs) exhibit broad-spectrum antibacterial activity and ...
Gareth E. Boer +3 more
doaj +1 more source
Chemical and Pharmaceutical Bulletin, 2010 Guanidines are categorized as strong organobases; however, their catalytic utility in organic synthesis has not been discussed thoroughly. The author's group has extensively and systematically studied their potential ability focusing on: 1) modified guanidines as chiral auxiliaries; 2) guanidinium ylides for aziridine formation; 3) the affinity of ...
openaire +3 more sources
, 2016 Modified guanidines were explored as potential chiral superbases. Thus, chiral 1,3-dimethyl-2-iminoimidazolidines with or without 4,5-diphenyl groups, their guanidinium salts, and the 2-iminoimidazolidines with (S)-1-phenylethyl groups on the ring ...
Keiko Fukuda (2640976) +2 more
core +1 more source
Molecules, 2021 This paper reports the synthesis of branched alkylene guanidines using microfluidic technologies. We describe the preparation of guanidine derivatives at lower temperatures, and with significantly less time than that required in the previously applicable
Denis O. Shatalov +10 more
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, 2016 An operationally straightforward and efficient method for the alkylation of carbamate-protected guanidines with various alkyl halides and mesylates is described. This protocol proceeds via deprotonation of the acidic N-carbamate hydrogen of the guanidine
David A. Powell (1503226) +2 more
core +1 more source
Detection and substitution-pattern determination of guanidines [PDF]
, 1976 The guanidine function can be detected and its substitution pattern determined taking into account the1H-NMR signals of the N−H and N−C−H groups. Satisfactory results were obtained with mono-to penta-substituted guanidines (as picrate salts).Facultad de ...
González, María Eugenia +2 more
core +2 more sources
Norepinephrine-Transporter-Targeted and DNA-Co-Targeted Theranostic Guanidines
, 2019 High risk neuroblastoma often recurs, even with aggressive treatments. Clinical evidence suggests that proliferative activities are predictive of poor outcomes.
Donald W. Coulter (6910190) +3 more
core +2 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Design and synthesis of a photoswitchable guanidine catalyst
Beilstein Journal of Organic Chemistry, 2012 A novel design as well as a straight-forward synthesis for a photoswitchable guanidine catalyst is reported. Intense studies of the photochromic properties demonstrated the reversible switchability of its photosensitive azobenzene moiety. Its activity in
Philipp Viehmann, Stefan Hecht
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Ultrasonics Sonochemistry, 2022 The chemotype of arylsulfonamide derivatives of cyclic arylguanidines is a source of molecules with valuable biological activities, including antimicrobial and antitumor properties.
Przemysław Zaręba +5 more
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