Results 31 to 40 of about 4,664 (240)

Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries

Molecules, 2019
The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries ...
David L. Perry, Bracken F. Roberts, Ginamarie Debevec, Heather A. Michaels, Debopam Chakrabarti, Adel Nefzi   +5 more
doaj   +1 more source

Eco-friendly methods of synthesis and preliminary biological evaluation of sulfonamide derivatives of cyclic arylguanidines

Ultrasonics Sonochemistry, 2022
The chemotype of arylsulfonamide derivatives of cyclic arylguanidines is a source of molecules with valuable biological activities, including antimicrobial and antitumor properties.
Przemysław Zaręba, Anna K. Drabczyk, Artur Wnorowski, Edyta Pindelska, Gniewomir Latacz, Jolanta Jaśkowska   +5 more
doaj   +1 more source

De Novo Autogenic Engineered Living Functional Materials

Advanced Materials, EarlyView.
A versatile platform for de novo autogenic engineered living materials is presented, leveraging protein mining, computational modeling, and synthetic biology. By reprogramming the Escherichia coli curli machinery with β‐solenoid proteins from non‐model bacteria, macroscopic biomaterials with enhanced mechanical properties, UV‐C irradiation protection ...
Hoda M. Hammad, Seth Swarnadeep, Erin C. Jackson, Nicolas Burns, Hongyu Wang, Harrison Priode, Robert B. Moore, Sanket Deshmukh, Avinash Manjula‐Basavanna, Anna M. Duraj‐Thatte   +9 more
wiley   +1 more source

Synthesis of an advanced intermediate of alfa-alloenduracididine from allylglycine

Orbital: The Electronic Journal of Chemistry, 2012
α-Alloenduracididine, 3-(2-amino-4,5-dihydro-1Himidazole-4-yl)-2-aminopropionic acid)1 and its diastereoisomer, enduracididine 2, are two nonproteinogenic amino acids isolated in 1968 from Streptomyces fungicidicus as part of a cyclopeptide the ...
Silvia Helena Cardoso, Mauro V. de Almeida, Josiane Thierry, Robert H. Dodd   +3 more
doaj   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Lipophilic mono-guanidines versus mono-(thio)ureas: anion transport, lipid binding, and antibacterial activity [PDF]

RSC Advances
Synthetic anion transporters (anionophores) can collapse ion gradients and have been widely explored as candidate therapeutics for channelopathies and cancer, yet their potential as antibacterial agents remains comparatively underdevelopped.
Randima D. De Silva Weerakonda Arachchige, Sarah R. Marshall, Hassan Gneid, Nathalie Busschaert   +3 more
doaj   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Harnessing Cation–Anion Synergistic Effect for High‐Performance Aqueous Zinc‐Ion Batteries

Angewandte Chemie, EarlyView.
Guanidine (CH6N3+) cations preferentially adsorb on the Zinc (Zn) anode surface, generating an electrostatic shielding effect to promote uniform Zn2+ deposition. Meanwhile, SO42– anions participate in constructing the solid electrolyte interface (SEI) on the Zn anode, forming a robust protective layer.
Weichen Li, Jiyang Liu, Junhong Guo, Anyao Song, Suli Chen, Ruwei Chen, Yunpeng Zhong, Yongkang Xing, Jihao Sun, Zhihong Tian, Guanjie He   +10 more
wiley   +2 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Dendritic surface functionalization of nanomaterials: controlling properties and functions for biomedical applications

Brazilian Journal of Pharmaceutical Sciences, 2013
A wide variety of nanomaterials have demonstrated promise in medical applications such as drug delivery and imaging. In these applications, the surface chemistry of the materials is critical as it plays an important role in determining the toxicity and ...
Ali Nazemi, Elizabeth R. Gillies
doaj   +1 more source